Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Achim Schmidtko"'
Autor:
Achim Schmidtko, Lea Kennel, Oliver Drees, Doris Koesling, Wiebke Kallenborn-Gerhardt, Jonas Petersen, Catherine Isabell Real, Rebecca Dorothee Steubing, Andreas Friebe, Evanthia Mergia, Ruirui Lu
Publikováno v:
Pain. 160:607-618
A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by 2 isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1
Autor:
Mirco Steger, Lea Kennel, Gerd Geisslinger, Ruirui Lu, Reynir Scheving, Irmgard Tegeder, Wiebke Kallenborn-Gerhardt, Aimee L. Edinger, Jonas Petersen, Jana E. Lorenz, Juliana Heidler, Christine V. Möser, Achim Schmidtko, Heinrich Heide, Cathrin Flauaus, Ilka Wittig
Publikováno v:
Pain. 158(7)
Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing. Recent data indicate that ROS can trigger specific redox-dependent signaling processes, but the molecular targe
Autor:
Oliver Drees, Andreas Friebe, Achim Schmidtko, Catherine Isabell Real, Jonas Petersen, Evanthia Mergia, Doris Koesling, Ruirui Lu
Publikováno v:
BMC Pharmacology & Toxicology
Background Chronic pain in response to tissue inflammation (inflammatory pain) or nerve injury (neuropathic pain) is often unresponsive to currently available treatments. A large body of evidence indicates that production of nitric oxide (NO) and act
Publikováno v:
The Lancet. 375:1569-1577
Summary Pharmacological management of severe chronic pain is difficult to achieve with currently available analgesic drugs, and remains a large unmet therapeutic need. The synthetic peptide ziconotide has been approved by the US Food and Drug Adminis
Autor:
Gerd Geisslinger, Carsten Stoetzer, Natasja deBruin, Ruirui Lu, Wiebke Kallenborn-Gerhardt, Robert Lukowski, Anne E. Bausch, Achim Schmidtko, Andreas Leffler, Peter Ruth
Slack (Slo2.2) is a sodium-activated potassium channel that regulates neuronal firing activities and patterns. Previous studies identified Slack in sensory neurons, but its contribution to acute and chronic painin vivoremains elusive. Here we generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46695b57995dd078a271211319fcdbb
https://publica.fraunhofer.de/handle/publica/240704
https://publica.fraunhofer.de/handle/publica/240704
Autor:
Wiebke Kallenborn-Gerhardt, Katharina M.J. Syhr, Ruirui Lu, Jana E. Lorenz, Achim Schmidtko, Gerd Geisslinger, Philip Eaton
Aims: Emerging lines of evidence indicate that oxidants such as hydrogen peroxide exert specific signaling functions during the processing of chronic pain. However, the mechanisms by which oxidants regulate pain processing in vivo remain poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fc04616079921f8ed41d33b8db9255
https://europepmc.org/articles/PMC4158966/
https://europepmc.org/articles/PMC4158966/
Chronic pain affects millions of people and often causes major health problems. Accumulating evidence indicates that the production of reactive oxygen species (ROS), such as superoxide anion or hydrogen peroxide, is increased in the nociceptive syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e506327a7b23baf92225042d66b0fc
https://publica.fraunhofer.de/handle/publica/244029
https://publica.fraunhofer.de/handle/publica/244029
Autor:
Gregor Vetter, Gerd Geisslinger, Helmut Schmidt, Christian Euchenhofer, Ellen Niederberger, Irmgard Tegeder, Sabine Grösch, Achim Schmidtko, Lutz Bräutigam
Publikováno v:
Europe PubMed Central
SPECIFIC AIMSCelecoxib is a cyclooxygenase-2 (COX-2) selective, nonsteroidal anti-inflammatory drug (NSAID) with low gastrointestinal toxicity. In clinical studies, 800 mg/day were somewhat less ef...
Publikováno v:
PainReferences. 139(3)
The synaptic vesicle protein synapsin II is specifically expressed in synaptic terminals of primary afferent nociceptive neurons and regulates transmitter release in the spinal cord dorsal horn. Here, we assessed its role in nerve injury-evoked molec
Autor:
Ovidiu Coste, Ellen Niederberger, Corina Ehnert, Achim Schmidtko, Claudiu Marian, Gerd Geisslinger
Publikováno v:
Biochemical and biophysical research communications. 346(2)
GLAST and GLT-1 are the most abundant glutamate transporters in the CNS and protect neurons from glutamate neurotoxicity. Here, we investigated the role of GLAST in spinal nociceptive processing. GLAST protein expression was not altered after treatme