Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Eunice Y. Lau, Man Tong, Katherine Po Sin Chung, Terence K. Lee, Stephanie Ma, Rainbow Wing Hei Leung, Etienne H. Mok, Irene Oi-Lin Ng, Martina Mang Leng Lei, Q Zhao, Vincent W. Keng, Carmen Oi Ning Leung, Hoi Wing Leung, Cong Ma
Publikováno v:
Cancer Research. 81:3229-3240
The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) is a possible way to reverse drug resistance, however, inhibitors that spec
Autor:
Xiao-Xiao Li, Jian Huang, Dewi Kenneth Rowlands, Shi Jie Zhang, Lilian H. Lo, Amy P. Chiu, Vincent W. Keng, Jinhui Wang
Publikováno v:
Cancer Medicine. 7:4791-4800
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. MPNSTs can occur either sporadically or in association with the neuro
Autor:
David A. Largaespada, Roser Pinyol, Bryant J. Keller, Barbara R. Tschida, Nuri A. Temiz, Helena Cornella, Timothy P. Kuka, Juan E. Abrahante, Michael A. Linden, Nicholas Koes, Khalid Amin, Gabriel Kaufmann, Germán L. Vélez-Reyes, Caitlin B. Conboy, Josep M. Llovet, Hsiangyu Hu, Vincent W. Keng, Clara Alsinet, Timothy K. Starr
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Autor:
Christopher L. Moertel, Adrienne L. Watson, Vincent W. Keng, David A. Largaespada, Natalie K. Wolf, Bernat Gel, Dominic A. Beckmann, Margaret H. Collins, Eduard Serra, Margaret R. Wallace, Aaron L. Sarver, Branden S. Moriarity, Kwangmin Choi, Nancy Ratner, Eric P. Rahrmann
Publikováno v:
Nature genetics
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome neurofibromatosis type 1. To identify genetic drivers of MPNST development, we used th
Autor:
Eric B. Schwartz, Walter J. Jessen, Jianqiang Wu, James R. Fuchs, Yuanshu Zou, Kevin A. T. Silverstein, Jose A. Cancelas, Deanna M. Patmore, Kwangmin Choi, Mi-Ok Kim, Edwin Jousma, Ami V. Patel, David A. Largaespada, Eva Dombi, Gang Huang, Barbara R. Tschida, David E. Levy, Jed J. Kendall, Vincent W. Keng, Robert J. Spinner, Danhua Fan, Nancy Ratner, Anat Stemmer-Rachamimov
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1979-1990 (2016)
SummaryTo identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4cd23be8f1a14cb8ed8e1e19cb857a
https://europepmc.org/articles/PMC4782770/
https://europepmc.org/articles/PMC4782770/
Autor:
David E. Levy, Jose A. Cancelas, Eva Dombi, Deanna M. Patmore, Edwin Jousma, Robert J. Spinner, Eric B. Schwartz, Vincent W. Keng, David A. Largaespada, Danhua Fan, Anat Stemmer-Rachamimov, James R. Fuchs, Nancy Ratner, Mi-Ok Kim, Jed K. Kendall, Kwangmin Choi, Yuanshu Zou
To identify genes and signaling pathways that drive peripheral nerve tumor initiation and growth beyond the Ras-MAPK pathway we used unbiased insertional mutagenesis screening. We identified Stat3 as a potential driver of Neurofibromatosis type 1 neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435f722f3bed806530e4ff2754e0d32b
https://europepmc.org/articles/PMC4218479/
https://europepmc.org/articles/PMC4218479/
Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers
Publikováno v:
Cancer Research. 76:63-63
Hepatocellular carcinoma (HCC), or liver cancer, is the second leading cause of death from cancer worldwide (Ferlay et al, Lyon, France: International Agency for Research on Cancer, 2013). HCC is linked with hepatic steatosis, or fatty liver disease,
Autor:
Timothy P. Kuka, Jason B. Bell, Branden S. Moriarity, Vincent W. Keng, David A. Largaespada, Barbara R. Tschida
Publikováno v:
Cancer Research. 74:929-929
The role of zinc finger and BTB domain containing 20 (ZBTB20) in hepatocellular carcinoma (HCC) is not well defined, as there are many discrepancies in the literature regarding its role in liver tumorigenesis. ZBTB20 has been implicated to play a rol
Autor:
David A. Largaespada, Reuben S. Harris, Vincent W. Keng, Timothy P. Kuka, Josep M. Llovet, Sara Toffanin, Hsiangyu Hu, Nuri A. Temiz, Bobbi R. Tschida, Timothy K. Starr, Caitlin B. Conboy, Michael B. Burns
Publikováno v:
Molecular Cancer Therapeutics. 12:A242-A242
Background: R-spondins are secreted agonists of Wnt signaling that function in development and promote tissue stem cell proliferation. Rspo2 was identified as a candidate oncogene in intestinal tumors via a Sleeping Beauty transposon insertional muta