Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David Lyden"'
Autor:
Martin P. Seybold, Han Sang Kim, Ayuko Hoshino, Knut M. Wittkowski, David Lyden, Christina Dadurian
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0199012 (2018)
PLoS ONE, Vol 13, Iss 7, p e0199012 (2018)
Most breast cancer deaths are caused by metastasis and treatment options beyond radiation and cytotoxic drugs, which have severe side effects, and hormonal treatments, which are or become ineffective for many patients, are urgently needed. This study
Autor:
Claudia Savini, Laura Benedetta Amato, Basant Kumar Thakur, Jacqueline Bromberg, Giuseppe Gasparre, Chiara Mastroleo, Monica Cricca, Ivana Kurelac, Qing Chang, Massimiliano Bonafè, Kunihiro Uryu, Alexander Galkin, Anna Stepanova, Pasquale Sansone, Larry Norton, Nadine Soplop, David Lyden, Luisa Iommarini, Ayuko Hoshino, Laura Daly, Antonio Strillacci
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(43)
The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit from dormancy have never been investigated. Here we identified the full mitochondrial genome in circulating extracellular vesicles (EVs) from patients with h
Autor:
Haiying Zhang, David Lyden
Publikováno v:
Science. 358:1127-1128
Cancer is a systemic disease. Tumor growth and malignant progression rely not only on the intrinsic aberrant genetic and epigenetic makeup of tumor cells but also on the tumor-induced systemic factors that affect cells in the primary tumor as well as
Autor:
Monica Cricca, Jennifer Nnoli, John H. Healey, Claudio Ceccarelli, Angela DeMichele, Michele Vidone, Jun J. Mao, Jacqueline Bromberg, Christopher Colameco, Marjan Berishaj, Michael Feldman, Vinagolu K. Rajasekhar, Nicola Fabbri, Natalie N. C. Shih, David Lyden, Laura Daly, Pasquale Sansone, Robert L. Bowman, Massimiliano Bonafè, Giuseppe Gasparre, Fabiana Perna, Mario Taffurelli, Qing Chang, Donatella Santini, Jinbo Chen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
The mechanisms of metastatic progression from hormonal therapy (HT) are largely unknown in luminal breast cancer. Here we demonstrate the enrichment of CD133hi/ERlo cancer cells in clinical specimens following neoadjuvant endocrine therapy and in HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12b18bb9d5cf60360e524b0e45abe1d
http://hdl.handle.net/11585/533940
http://hdl.handle.net/11585/533940
Autor:
Aru Narendran, Mary S. Brady, Haiying Zhang, Swarnima Singh, Mina J. Bissell, Joshua Mitchell Weiss, Angela Di Giannatale, Linda Bojmar, Maria de Sousa, Gonçalo Rodrigues, Volkmar Müller, Kavita Mallya, Gary K. Schwartz, Vinagolu K. Rajasekhar, Henrik Molina, Sukwinder Kaur, Michael A. Hollingsworth, Per Sandström, Alexander E. Davies, Shinji Kohsaka, Kimberly Kramer, Nadine Soplop, Andy J. Minn, Irina Matei, Lindsay A. Pharmer, Sophia Ceder, David Lyden, Benjamin A. Garcia, Jacqueline Bromberg, Tang-Long Shen, Elin H. Kure, Cyrus M. Ghajar, Héctor Peinado, Ayako Hashimoto, Knut Jørgen Labori, Caitlin Williams, William R. Jarnagin, Jonathan M. Hernandez, Vanessa D. Dumont-Cole, John H. Healey, Øystein Fodstad, Ayuko Hoshino, Yibin Kang, Yonathan Ararso, Klaus Pantel, Tari A. King, Tuo Zhang, Milica Tesic Mark, Leonard H. Wexler, Surinder K. Batra, Maneesh Jain, Paul M. Grandgenett, Bruno Costa-Silva, Kunihiro Uryu
Publikováno v:
Nature, vol 527, iss 7578
Nature
Hoshino, A; Costa-Silva, B; Shen, TL; Rodrigues, G; Hashimoto, A; Tesic Mark, M; et al.(2015). Tumour exosome integrins determine organotropic metastasis. Nature, 527(7578), 329-335. doi: 10.1038/nature15756. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/60s4z9wm
Nature
Hoshino, A; Costa-Silva, B; Shen, TL; Rodrigues, G; Hashimoto, A; Tesic Mark, M; et al.(2015). Tumour exosome integrins determine organotropic metastasis. Nature, 527(7578), 329-335. doi: 10.1038/nature15756. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/60s4z9wm
© 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8408ae12ab5df6d9b94376be7d65dc61
https://escholarship.org/uc/item/60s4z9wm
https://escholarship.org/uc/item/60s4z9wm
Autor:
David Lyden, Ayuko Hoshino
Publikováno v:
Nature. 546:609-610
The growth factor MIDKINE, which is secreted by skin tumours called melanomas, stimulates the formation of lymphatic vessels at distant lymph nodes and organ sites, paving the way for metastatic cancer spread. See Letter p.676 Lymph nodes are a commo
Autor:
David Lyden, Shahin Rafii
Publikováno v:
Science. 357:1168-1168
Tumor metastasis is a multistep process that includes stimulation of angiogenesis, intravasation of tumor cells into blood or lymphatic vessels, and subsequent engraftment and extravasation to peripheral tissues where secondary tumors are seeded. It
Autor:
Yaron S.N. Butterfield, David Shih, Janet C. Lindsey, Olivier Ayrault, James T. Rutka, Carlos Gilberto Carlotti, Borja L. Holgado, Livia Garzia, Ji Yeoun Lee, Paul A. Northcott, Laura K. Donovan, K. A. Michealraj, Vijay Ramaswamy, Toshihiro Kumabe, Nada Jabado, Thomas Zeng, Michael A. Grotzer, Michael D. Taylor, Jessica Liu, Darlene Lee, Eric Chuah, Gudrun Fleischhack, Scott Zuyderduyn, Xi Huang, Andrey Korshunov, Jacqueline E. Schein, Steven C. Clifford, Ute Bartels, V. Peter Collins, Peter B. Dirks, Stuart Matan-Lithwick, Claudia C. Faria, Daniel W. Fults, Xiao-Nan Li, Tobey J. MacDonald, Yusanne Ma, Mikhail Bilenky, Inanc Birol, Gary D. Bader, Nina Thiessen, Anne Bendel, Marc Remke, Eloi Mercier, Alex Manno, Haiyan I. Li, William A. Weiss, Stéphanie Puget, Noreen Dhalla, Marco A. Marra, Wendy J. Ingram, Sohrab P. Shah, Stefan M. Pfister, Ulrich Schüller, José Pimentel, Jaroslav Sterba, Marcel Kool, Ronald L. Hamilton, Lei Qin, Seung-Ki Kim, An He, Trevor J. Pugh, Stephen C. Mack, Kory Zayne, Xin Wang, Yoon Jae Cho, Kyu-Chang Wang, Patryk Skowron, Betty Luu, Ian F. Pollack, Cynthia Hawkins, Erwin G. Van Meir, Salomeh Jelveh, Andrew J. Mungall, Caitlin Hoffman, Andrew W. Walter, Helen Wheeler, Adi Rolider, Young Cheng, Michael K. Cooper, A. Sorana Morrissy, Jüri Reimand, Uri Tabori, Michael Mayo, Hamza Farooq, Florence M.G. Cavalli, Maria Luisa Garrè, Eric Bouffet, Adrian Ally, Richard A. Moore, Yongjun Zhao, Duncan Stearns, William Long, Richard Corbett, Karel Zitterbart, Yisu Li, Jeffrey H. Wisoff, Tina Wong, Robert J. Wechsler-Reya, Simon Bailey, Yuan Yao Thompson, Lara S. Collier, Luca Massimi, Andrew R. Hallahan, Byung Kyu Cho, Torsten Pietsch, David Lyden, Teiji Tominaga, Angela Tam, James Garvin, Roger J. Packer, John Peacock, Jeffrey J. Olson, Karey Shumansky, Adam J. Dupuy, Kane Tse, David A. Largaespada, Sandra E. Dunn, David T.W. Jones, Young Shin Ra, Patricia Lindsay, Tarek Shalaby, Rebecca Carlsen, Patrick Plettner, Andrew Roth, Chelsea Mayoh, Karen Mungall, Charles G. Eberhart, Xiaochong Wu, Daniela Pretti da Cunha Tirapelli, Sofia Nunes, Jenny Q. Qian, David Malkin, Maura Massimino, John J.Y. Lee, Steven J.M. Jones, Stephan Tippelt, Carolina Nor, Noriyuki Kijima
Publikováno v:
Nature. 529(7586)
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma wi
Autor:
Shahin Rafii, Adriana Haimovitz-Friedman, Richard Kolesnick, David Lyden, François Paris, Carlos Cordon-Cardo, Zvi Fuks, Monica Garcia-Barros
Publikováno v:
Science. 300:1155-1159
About 50% of cancer patients receive radiation therapy. Here we investigated the hypothesis that tumor response to radiation is determined not only by tumor cell phenotype but also by microvascular sensitivity. MCA/129 fibrosarcomas and B16F1 melanom
Autor:
Kevin C. De Braganca, Jill M. Kolesar, Yasmin Khakoo, Tanya M. Trippett, Kim Kramer, Shakeel Modak, Stephen Gilheeney, Brian H. Kushner, Oren J. Becher, Jason T. Huse, Nai-Kong V. Cheung, David Lyden, Nathan E. Millard, Sofia Haque, Ira J. Dunkel, Ivan Spasojevic
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178593 (2017)
PLoS ONE
PLoS ONE
The PI3K/Akt/mTOR signaling pathway is aberrantly activated in various pediatric tumors. We conducted a phase I study of the Akt inhibitor perifosine in patients with recurrent/refractory pediatric CNS and solid tumors. This was a standard 3+3 open-l