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pro vyhledávání: '"Linda Cheung"'
Autor:
Shiguang Liu, Duane Delimont, Brianna Dufek, Michael Anne Gratton, Linda Cheung, Wenping Song, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove
Publikováno v:
Kidney International. 90:300-310
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the subcapillar
Autor:
Sylvie Abouna, Michael Khan, Goran Mattsson, Stella Pelengaris, Linda Cheung, Luxian Zhou, Vasiliki Ifandi, Sevasti Zervou
Publikováno v:
Islets. 2(1)
c-Myc (Myc) is a mediator of glucotoxicity but could also independently compromise β-cell survival and function. We have shown that after Myc activation in adult β-cells in vivo, apoptosis is preceded by hyperglycemia, suggesting glucotoxicity migh
Autor:
Duane Delimont, Velidi H. Rao, Dominic Cosgrove, Steven C. Sansom, Marisa Zallocchi, Linda Cheung, J. David Holzclaw, Daniel T. Meehan
Publikováno v:
Kidney international. 76(9)
Alport glomerular disease is associated with dysregulation of pro-inflammatory cytokines and matrix metalloproteinases, promoting progressive glomerulonephritis. Changes in composition and structure of Alport GBM resulting from mutations in type IV c