Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yosra Aljawai"'
Autor:
Angelo Vacca, Luis Palomera, Yawara Kawano, Irene M. Ghobrial, Marta Chesi, Antonio Sacco, Siobhan Glavey, Michele Moschetta, Ilyas Sahin, Felipe Prosper, Bruno Paiva, Leif Bergsagel, Matteo Bellone, Salomon Manier, Jiantao Shi, Yosra Aljawai, Michaela R. Reagan, Aldo M. Roccaro, Arianna Calcinotto, Yuji Mishima, C Unitt
Publikováno v:
Leukemia. 30:1103-1115
The role of endothelial progenitor cell (EPC)-mediated vasculogenesis in hematological malignancies is not well explored. Here, we showed that EPCs are mobilized from the bone marrow (BM) to the peripheral blood at early stages of multiple myeloma (M
Autor:
Michele Moschetta, Irene M. Ghobrial, Michelle Kuhne, Salomon Manier, Elizabeth A. Morgan, Michele Cea, Ilyas Sahin, Yu-Tzu Tai, Jiantao Shi, Franziska Michor, Aldo M. Roccaro, Yuji Mishima, Yong Zhang, Daisy Huynh, Siobhan Glavey, Michaela R. Reagan, Yosra Aljawai, Chin Pan, Yawara Kawano, Marco Chiarini, Pina M. Cardarelli, Antonio Sacco
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 622-635 (2015)
Extra-medullary disease (EMD) in Multiple Myeloma (MM) is associated with poor prognosis and resistance to chemotherapy. However, molecular alterations that lead to EMD have not been well defined. We developed bone marrow (BM)- and EMD-prone MM synge
Autor:
Patricia Maiso, John M. Asara, Aldo M. Roccaro, Irene M. Ghobrial, Daisy Huynh, Alec C. Kimmelman, Yuji Mishima, Yosra Aljawai, Antonio Sacco, Michele Moschetta
Publikováno v:
Cancer Research. 75:2071-2082
Drug resistance remains a major clinical challenge for cancer treatment. Multiple myeloma is an incurable plasma cell cancer selectively localized in the bone marrow. The main cause of resistance in myeloma is the minimal residual disease cells that
Autor:
Zhi Ning Lu, Yu-Tzu Tai, Irene M. Ghobrial, Yu Zhang, Antonio Sacco, Yong Zhang, Jiantao Shi, Salomon Manier, Masoumeh Memarzadeh, Siobhan Glavey, John E. Ready, Yuji Mishima, David L. Kaplan, Yosra Aljawai, Michaela R. Reagan, Aldo M. Roccaro
Publikováno v:
Blood. 124:3250-3259
Clonal proliferation of plasma cells within the bone marrow (BM) affects local cells, such as mesenchymal stromal cells (MSCs), leading to osteolysis and fatality in multiple myeloma (MM). Consequently, there is an urgent need to find better mechanis
Autor:
Joseph Cappuccio, Steven P. Treon, Irene M. Ghobrial, Serena McDiarmid, Jorge J. Castillo, Jacob P. Laubach, Houry Leblebjian, Claudia E. Paba-Prada, Edie Weller, Aldo M. Roccaro, Elizabeth A. Morgan, Robert A. Redd, Ranjit Banwait, Yosra Aljawai
Publikováno v:
American Journal of Hematology. 90:100-104
Disease assessment in Waldenstrom Macroglobulinemia (WM) is dependent on the percent involvement of B-cell neoplasm in the bone marrow and IgM paraprotein in the serum. A subset of patients also demonstrates extramedullary involvement, which is infre
Autor:
Lena Al-Harthi, Srinivas D. Narasipura, Yosra Aljawai, Maureen H. Richards, Melanie S. Seaton
Publikováno v:
Current HIV Research. 12:164-173
Cells of the monocyte/macrophage lineage are an important target for HIV-1 infection. They are often at anatomical sites linked to HIV-1 transmission and are an important vehicle for disseminating HIV-1 throughout the body, including the central nerv
Autor:
Irene M. Ghobrial, Jacob P. Laubach, Nikhil C. Munshi, Claudia E. Paba-Prada, Mathew Weinstock, Robert L. Schlossman, Edie Weller, Cindy Varga, Muriel Gannon, Yosra Aljawai, Paul P. Richardson, Constantine S. Mitsiades, Aldo M. Roccaro, Kenneth C. Anderson, Elizabeth A. Morgan
Extramedullary disease (EMD), defined as an infiltrate of clonal plasma cells at an anatomic site distant from the bone marrow, is an uncommon manifestation of multiple myeloma. Six hundred and sixty-three consecutive patients with multiple myeloma w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f59acd6d5070256641dd85e29fc4755
https://europepmc.org/articles/PMC5944324/
https://europepmc.org/articles/PMC5944324/
Autor:
Yuji Mishima, Bruno Paiva, Jiantao Shi, Mira Massoud, Salomon Manier, Adriana Perilla-Glen, Yosra Aljawai, Satoshi Takagi, Daisy Huynh, Aldo Roccaro, Antonio Sacco, Diego Alignani, Maria-Victoria Mateos, Joan Blade, Juan-Jose Lahuerta, Paul Richardson, Jacob Laubach, Robert Schlossman, Kenneth Anderson, Nikhil Munshi, Felipe Prosper, Jesus San Miguel, Franziska Michor, Irene M. Ghobrial
Publikováno v:
Molecular Cancer Therapeutics. 14:A82-A82
Introduction: Genomic sequencing of tumor cells obtained from the bone marrow (BM) of patients with multiple myeloma (MM) has demonstrated significant clonal heterogeneity. However, it could be envisioned that such clonal diversity may be even higher
Autor:
Fabio Facchetti, Irene M. Ghobrial, Yuji Mishima, Michele Moschetta, Aldo M. Roccaro, Anna Kruschinski, Antonio Sacco, Giuseppe Rossi, Yosra Aljawai, Patricia Maiso
Publikováno v:
Cancer Research. 75:PR14-PR14
Background. Multiple myeloma (MM) patients present with multiple lytic lesions at diagnosis, indicating the presence of continuous dissemination of MM cells from the primary site of tumor development to multiple distant bone marrow (BM) niches. We hy
Autor:
Paul G. Richardson, Jacob P. Laubach, Cindy Varga, Irene M. Ghobrial, Constantine S. Mitsiades, Aldo M. Roccaro, Matthew Weinstock, Yosra Aljawai, Kenneth C. Anderson, Nikhil C. Munshi, Muriel Gannon, Elizabeth A. Morgan, Robert L. Schlossman, Claudia E. Paba-Prada
Publikováno v:
Blood. 124:5746-5746
Background: Extramedullary disease (EMD), strictly defined as an infiltrate of clonal plasma cells at an anatomic site distant from the bone marrow or adjacent soft tissue in a patient with underlying multiple myeloma, is an uncommon manifestation of