Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Wen, S"'
Autor:
Wen S. Looi, Eric Sandler, Julie A. Bradley, Philipp R. Aldana, Adam L. Holtzman, Daniel J. Indelicato, Christopher G. Morris, Ronny L Rotondo, Raymond B. Mailhot Vega
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 109:1406-1413
Purpose Due to the location and high dose required for disease control, pediatric chordomas are theoretically well-suited for treatment with proton therapy, but their low incidence limits the clinical outcome data available in the literature. We soug
Publikováno v:
Glia
Microglial cells are the main reservoir for HIV-1 within the brain and potential exists for negative immune checkpoint blockade therapies to purge this viral reservoir. Here, we investigated cytolytic responses of CD8(+) T lymphocytes against microgl
Publikováno v:
iScience
iScience, Vol 20, Iss, Pp 512-526 (2019)
iScience, Vol 20, Iss, Pp 512-526 (2019)
Summary HIV-associated neurocognitive disorders (HAND) persist even during effective combination antiretroviral therapy (cART). Although the cause of HAND is unknown, studies link chronic immune activation, neuroinflammation, and cerebrospinal fluid
Publikováno v:
Brain Sciences
Volume 11
Issue 11
Brain Sciences, Vol 11, Iss 1482, p 1482 (2021)
Volume 11
Issue 11
Brain Sciences, Vol 11, Iss 1482, p 1482 (2021)
The role of select pro- and anti-inflammatory mediators in driving microglial cell polarization into classically (M1), or alternatively, (M2) activated states, as well as the subsequent differential responses of these induced phenotypes, was examined
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bTRM) may respond tode novo-produced viral Ag through the rapid release of IFN-γ, which drives subsequent interferon-stimulated gene express
Autor:
Chun L. Mu, Yuan Liu, Qi L. Xiong, Li Zhang, Yu X. Chen, Wen S. Hou, Xiao Y. Wu, Zheng J. Yi, Chun F. Deng
Publikováno v:
EMBC
Hands and knees crawling is an important motor developmental milestone, which is characterized by diagonal coordination between upper and lower limbs. However, the features of inter-joint synergy within each limb in infant crawling is still not clear
Publikováno v:
IEEE Transactions on Neural Systems and Rehabilitation Engineering. 26:780-787
Hands and knees crawling is an important motor developmental milestone but the current clinical measures of motor function during crawling stage are relatively subjective. Objective metrics using kinematics and electromyography (EMG) in infant crawli
Publikováno v:
Immunity, Inflammation and Disease. 6:332-344
Introduction Previous work from our laboratory has demonstrated in vivo persistence of CD103+ CD69+ brain resident memory CD8+ T-cells (bTRM ) following viral infection, and that the PD-1: PD-L1 pathway promotes development of these TRM cells within
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Peripheral neuropathy is currently the most common neurological complication in HIV-infected individuals, occurring in 35–50% of patients undergoing combination anti-retroviral therapy. Data have shown that distal symmetric polyneuropath
Publikováno v:
Pain Research and Management, Vol 2019 (2019)
Pain Research & Management
Pain Research & Management
The most common neurological complication in patients receiving successful combination antiretroviral therapy (cART) is peripheral neuropathic pain. Data show that distal symmetric polyneuropathy (DSP) also develops along with murine acquired immunod