Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Wei-Yi Ong"'
Autor:
Venetia Kok Jing Tong, Sylvester Wong Shu Ming, Kah-Leong Lim, Ziyin Wang, Rafhanah Banu Bte Abdul Razar, Saravanan Gunaseelan, Sumitra Srimasorn, Wei-Yi Ong, John Jia En Chua
Publikováno v:
Human Molecular Genetics. 30:5-20
FEZ1-mediated axonal transport plays important roles in central nervous system development but its involvement in the peripheral nervous system is not well-characterized. FEZ1 is deleted in Jacobsen syndrome (JS), an 11q terminal deletion development
Autor:
Wei-Yi Ong, Samantha Chia Yi Ooi, Sally Shuxian Koh, Cao Qiong, Leona Ting Yuke Ho, Irwin K. Cheah, Barry Halliwell, Natalie Man Yin Lui, Deron R. Herr
Publikováno v:
NeuroMolecular Medicine
Neuromolecular Medicine
Neuromolecular Medicine
Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current s
Autor:
Wan Shun Daniel Tan, Wei-Yi Ong, Sally Shuxian Koh, Wai Shiu Fred Wong, Deron R. Herr, Ting Yu Amelia Yam, Kanokporn Chayaburakul
Publikováno v:
Neuromolecular Medicine
Microglial cells are resident macrophages of the central nervous system (CNS) that respond to bioactive lipids such as docosahexaenoic acid (DHA). Low micromolar concentrations of DHA typically promote anti-inflammatory functions of microglia, but hi
Publikováno v:
Molecular Neurobiology. 57:372-392
Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma and cerebrospinal fluid (CSF). It has two known enzymatic activities, acting as both a phosphodiesterase and a phospholipase. The majority of its biological effect
Autor:
Jasmine Hui Min Lee, Tatsuma Hind, Jerold Chun, Siew Mon Lim, Nicholas Wei Jie Hay, Wei-Yi Ong, Malavika Srikanth, Deron R. Herr, Wee Siong Chew, Rich Rivera
Publikováno v:
European Journal of Pharmacology. 841:49-56
Lysophosphatidic acid receptor 1 (LPA1) is one of six G protein-coupled receptors (GPCRs) activated by the bioactive lipid, lysophosphatidic acid (LPA). Previous studies have shown that LPA1 signaling plays a major role in the pathophysiology of neur
Autor:
Malavika Srikanth, Kalashobini Chandrasaharan, Deron R. Herr, Wei-Yi Ong, Xinyuan Zhao, Kanokporn Chayaburakul
Publikováno v:
NeuroMolecular Medicine. 20:504-514
DHA is one of the most abundant fatty acids in the brain, largely present in stores of membrane phospholipids. It is readily released by the action of phospholipase A2 and is known to induce anti-inflammatory and neurotrophic effects. It is not thoug
Publikováno v:
Molecular Neurobiology
The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas of the cerebral neocortex, hippocampus, periaqueductal gray (PAG), thalamus, amygdala, and b
Publikováno v:
Molecular Neurobiology
The Traditional Chinese Medicine (TCM) theory that “kidneys give rise to marrow, and the brain is the sea of marrow” has been a guide for the clinical application of kidney, qi and blood tonics for prevention and treatment of dementia and improve
Publikováno v:
Neurochemistry International. 146:105018
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which modulates vascular integrity through its receptors, S1P1-S1P5. Notably, S1P2 has been shown to mediate the disruption of cerebrovascular integrity in vitro and in vivo. However, the mech
Autor:
Jie-Xin Tong, Wei-Yi Ong, Gavin S. Dawe, Eng Shi Ong, Suku-Maran Shalini, Yee-Kong Ng, Christabel Fung-Yih Ho, Deron R. Herr
Publikováno v:
Molecular Neurobiology
Docosahexaenoic acid (DHA) is enriched in membrane phospholipids of the central nervous system (CNS) and has a role in aging and neuropsychiatric disorders. DHA is metabolized by the enzyme Alox15 to 17S-hydroxy-DHA, which is then converted to 7S-hyd