Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Tsutomu Sasaki"'
Autor:
Wilder Alberto Palomino A, Bruce A. Lessey, David P. Schammel, Jae Wook Jeong, Tae Hoon Kim, Tsutomu Sasaki, Steven L. Young, Jeffrey L Deaton
Publikováno v:
J Clin Endocrinol Metab
Context Progesterone resistance, a known pathologic condition associated with a reduced cellular response to progesterone and heightened estrogen responses, appears to have a normal physiologic role in mammalian reproduction. The molecular mechanism
Autor:
Hirofumi Hanaoka, Miki Matsui, Ayumu Konno, Hiroki Matsui, Norimichi Koitabashi, Hideyuki Kabasawa, Masaru Obokata, Akihiko Saito, Motoko Yanagita, Sawako Goto, Michihiro Hosojima, Ryo Kawakami, Masahiko Kurabayashi, Hiroaki Sunaga, Shreya Shrestha, Tsutomu Sasaki, Ryosuke Kaneko, Suman Shrestha, Tatsuya Iso, Hirokazu Hirai
Publikováno v:
The Journal of Pathology. 255:362-373
Urinary fatty acid binding protein 1 (FABP1, also known as liver-type FABP) has been implicated as a biomarker of acute kidney injury (AKI) in humans. However, the precise biological mechanisms underlying its elevation remain elusive. Here, we show t
Autor:
Hideki Mochizuki, Shiying Jiang, Kousuke Baba, Kensuke Ikenaka, Hideki Hayakawa, Makoto Kinoshita, Seiichi Nagano, Chi-Jing Choong, Tsutomu Sasaki, Tatsusada Okuno, Keisuke Hagihara, Hiroshi Sakiyama, Munehisa Shimamura, Yoshitaka Nagai
Publikováno v:
Neurotherapeutics
Go-sha-jinki-Gan (GJG) is a traditional Japanese herbal medicine. In clinical practice, GJG is effective against neuropathic pain and hypersensitivity induced by chemotherapy or diabetes. In our previous study using a chronic constriction injury mous
Autor:
Atsushi Ozawa, Daisuke Kohno, Hideo Akiyama, Akihiro Harada, Nobuyuki Shibusawa, Masanobu Yamada, Tsutomu Sasaki, Sayaka Yamada, Hideaki Yokoo, Yuri Kondo, Kazuhiko Horiguchi, Yasuyo Nakajima, Kazuma Saito, Tadahiro Kitamura, Battsetseg Buyandalai
Publikováno v:
Thyroid.
Background Thyrotropin-releasing hormone (TRH) was the first hypothalamic hormone isolated that stimulates pituitary thyroid-stimulating hormone (TSH) secretion. TRH was also later found to be a stimulator of pituitary prolactin and distributed throu
Autor:
Tadahiro Kitamura, Kazuko Saeki, Yoshio Fujitani, Tsutomu Sasaki, Hirotaka Watada, Takehiko Yokomizo, Daisuke Kohno, Tomoaki Koga, Takeshi Miyatsuka, Toshiaki Okuno, Saiko Kazuno, Airi Jo-Watanabe, Ayako Fukunaka, Hirotsugu Uzawa
Publikováno v:
The FASEB Journal. 34:13949-13958
Obesity is a health problem worldwide, and brown adipose tissue (BAT) is important for energy expenditure. Here, we explored the role of leukotriene A4 hydrolase (LTA4 H), a key enzyme in the synthesis of the lipid mediator leukotriene B4 (LTB4 ), in
Autor:
Shigenobu Matsumura, Mayuki Odanaka, Tsutomu Sasaki, Mark Christian C. Manio, Fuka Ishikawa, Kazuo Inoue, Tohru Fushiki
Publikováno v:
Physiology & Behavior. 204:112-120
Corticosterone (CORT) is a powerful regulator of energy metabolism, and chronically high CORT levels cause obesity and diabetes in mice. It is reported that a chronically high CORT level changes food preference, increasing the intake of comfort foods
Autor:
Satoru Tada, Eri Sanda, Kazushiro Takata, Kazuya Yamashita, Hideki Mochizuki, Toru Koda, Hisae Sumi-Akamaru, Akiko Namba, Tsutomu Sasaki, Makoto Kinoshita, Chi-Jing Choong, Tatsusada Okuno, Shigeru Miyagawa, Mikito Shimizu, Yuji Nakatsuji, Yoshiki Sawa, Yoshiki Sakai
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by several pathologies including oxidative stress, apoptosis, neuroinflammation, and glutamate toxicity. Although multiple reports suggest that ischemia and
Autor:
Tomohiro Yamasaki, Toshimitsu Watanabe, Shigenobu Matsumura, Kazuhiro Nakamura, Chika Nishimura, Naoya Sowa, Takahiro Horie, Tomohiro Nishino, Yui Miyasaka, Sijia Xu, Masataka Nishiga, Randolph Ruiz Rodriguez, Yasuhide Kuwabara, Yasuhiro Nakashima, Chiharu Otani, Dai Watanabe, Haruhisa Inoue, Shin Watanabe, Yuya Ide, Tetsushi Nakao, Aoi Omori, Fumiko Nakazeki, Hitoo Nishi, Takeshi Kimura, Shuhei Tsuji, Osamu Baba, Jin Tanaka, Tsutomu Sasaki, Kazuki Matsushita, Sawa Miyagawa, Marina R. Picciotto, Masahiro Kimura, Koh Ono
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in th
Autor:
Kenichi Todo, Hiroshi Takemori, Kumiko Nishiyama, Tomohiro Kawano, Shigenobu Matsumura, Hideaki Kanki, Shuhei Okazaki, Tsutomu Sasaki, Hideki Mochizuki
Publikováno v:
J Neurosci
The cAMP pathway is known to stabilize endothelial barrier function and maintain vascular physiology. The family of cAMP-response element binding (CREB)-regulated transcription coactivators (CRTC)1–3 activate transcription by targeting the basic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07711f01994e164bdaf9de8884024ca
https://europepmc.org/articles/PMC7724130/
https://europepmc.org/articles/PMC7724130/
Autor:
Takayoshi Suga, Daisuke Kohno, Yuichi Ikeuchi, Touko Hirano, Hideru Obinata, Hiromi Yokota-Hashimoto, Eri Wada, Tsutomu Sasaki, Sho Matsui, Masaki Kobayashi, Tadahiro Kitamura, Haruka Tsuneoka, Norikiyo Honzawa, Osamu Kikuchi
Publikováno v:
The Journal of Nutritional Biochemistry. 97:108811
Dysregulation of glucagon is associated with the pathophysiology of type 2 diabetes. We previously reported that postprandial hyperglucagonemia is more obvious than fasting hyperglucagonemia in type 2 diabetes patients. However, which nutrient stimul