Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Terrence L. Geiger"'
Publikováno v:
Curr Opin Biotechnol
T cells shape immune responses in cancer, autoimmunity and infection, in which CD4(+) T helper (Th) and CD8(+) T cells mediate effector responses that are suppressed by regulatory T (T(reg)) cells. The balance between effector T cell and T(reg) cell
Publikováno v:
The Journal of Immunology. 201:2934-2946
IL-6 is a critical driver of acute and chronic inflammation and has been reported to act as a T cell survival factor. The influence of IL-6 on T cell homeostasis is not well resolved. We demonstrate that IL-6 signaling drives T cell expansion under i
Autor:
Caitlin C. Zebley, Wenting Zheng, Terrence L. Geiger, Jayadev Mavuluri, Benjamin Youngblood, Yong-Dong Wang, Lindsay L. Jones, Lingyun Long, Yiping Fan, Hongbo Chi, Jun Wei, Yogesh Dhungana
Publikováno v:
Blood
Chimeric antigen receptor (CAR)–T-cell therapeutic efficacy is associated with long-term T-cell persistence and acquisition of memory. Memory-subset formation requires T-cell factor 1 (TCF-1), a master transcription factor for which few regulators
Autor:
Terrence L. Geiger, Hossam A. Abdelsamed, Ben Youngblood, Rajshekhar Alli, Carol E. O’Hear, Jacob Halum Basham, Wenting Zheng, Lance E. Palmer, Lindsay L. Jones
Publikováno v:
Leukemia. 32:1157-1167
In vivo persistence of chimeric antigen receptor (CAR)-modified T cells correlates with therapeutic efficacy, yet CAR-specific factors that support persistence are not well resolved. Using a CD33-specific CAR in an acute myeloid leukemia (AML) model,
Autor:
Benjamin Youngblood, Robert A. Carter, Charles G. Mullighan, Mari Hashitate Dallas, Douglas R. Green, Jinghui Zhang, Hossam A. Abdelsamed, Ardiana Moustaki, Taosheng Chen, Walid Awad, Terrence L. Geiger, Xi-zhi J. Guo, James R. Downing, Yongjin Li, E. Kaitlynn Allen, Jesse Bakke, Anthony E. Zamora, Ti-Cheng Chang, Jeremy Chase Crawford, Paul G. Thomas
Publikováno v:
Science Translational Medicine. 11
Cancer arises from the accumulation of genetic alterations, which can lead to the production of mutant proteins not expressed by normal cells. These mutant proteins can be processed and presented on the cell surface by major histocompatibility comple
Autor:
Wenting Zheng, Jordy Saravia, Jiyang Yu, Yogesh Dhungana, Hongling Huang, Hongbo Chi, Yanyan Wang, Anil Kc, Jun Wei, John G. Doench, Lingyun Long, Chenxi Qian, Yong-Dong Wang, Seon Ah Lim, Cliff Guy, Terrence L. Geiger, Beisi Xu
Publikováno v:
Nature
Adoptive cell therapy represents a new paradigm in cancer immunotherapy, but it can be limited by the poor persistence and function of transferred T cells1. Here we use an in vivo pooled CRISPR-Cas9 mutagenesis screening approach to demonstrate that,
Publikováno v:
The Journal of Immunology. 196:2973-2985
How a large number of cytokines differentially signal through a small number of signal transduction pathways is not well resolved. This is particularly true for IL-6 and IL-10, which act primarily through STAT3 yet induce dissimilar transcriptional p
Autor:
Casey D. Morrow, Catherine Walker, Nita H. Salzman, Anthony A. Fodor, Ranjit Kumar, Lydia C. Cook, Sreemanti Basu, Terrence L. Geiger, Avijit Ray, Raad Z. Gharaibeh, Elliot J. Lefkowitz, Craig L. Franklin, Bonnie N. Dittel
Publikováno v:
The Journal of Immunology. 195:3071-3085
It is clear that IL-10 plays an essential role in maintaining homeostasis in the gut in response to the microbiome. However, it is unknown whether IL-10 also facilitates immune homeostasis at distal sites. To address this question, we asked whether s
Autor:
Lennart T. Mars, Jean-Charles Guéry, Abdulraouf Ramadan, Miriam Eisenstein, Roland S. Liblau, Liliana E. Lucca, Phuong Nguyen, Alessandro Sette, Nadège Carrié, Avraham Ben-Nun, Sabine Desbois, Terrence L. Geiger
Publikováno v:
The Journal of Immunology. 193:3267-3277
The recognition of multiple ligands by a single TCR is an intrinsic feature of T cell biology, with important consequences for physiological and pathological processes. Polyspecific T cells targeting distinct self-antigens have been identified in hea
Publikováno v:
The Journal of Immunology. 189:669-678
IL-10 is a critical anti-inflammatory cytokine, the deficiency of which leads to spontaneous autoimmunity. However, therapeutically administered or ectopically expressed IL-10 can either suppress or promote disease. Distinct lineage-specific activiti