Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Stephen Devereux"'
Autor:
Christopher Fegan, Christopher I. Jones, Eve Coulter, Chris Pepper, Emma Halliwell, Emma Kennedy, Barnaby Clark, Stephen Devereux, Angelo Agathanggelou, Timothy Chevassut, Thomas A Burley, Rosalynd Johnston, Tatjana Stankovic, Elisabeth Jane Walsby, Ceri E. Oldreive, Triantafillos Liloglou, Elizabeth H Phillips, Andrea Pepper, Nick Davies, Martina Seiffert, Ralph Schulz, Simon Mitchell, Nuria Profitos-Peleja
Publikováno v:
Phillips, E 2021, ' TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target. ', Blood, vol. 137, no. 22, pp. 3064-3078 . https://doi.org/10.1182/blood.2020005964
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Chronic lymphocytic leukemia (CLL) remains incurable despite B-cell receptor–targeted inhibitors revolutionizing treatment. This suggests that other signaling molecules are involved in disease escape mechanisms and resistance. Toll-like receptor 9
Autor:
Joop Gaken, Ghulam J. Mufti, Farzin Farzaneh, M Kemeny, Nicola Hardwick, Lucas Chan, Stephen Devereux, Joanna Galea-Lauri, D. Darling
Despite recent treatment advances prognosis for the majority of AML patients remains bleak. AML patients over 60 years of age treated with intensive chemotherapy have an estimated 2-year survival of 20% and only 10% at 4–5 years. This is attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed9428260c47c2f13bfc45ff5b37665
https://ora.ox.ac.uk/objects/uuid:f33dd5f8-0d10-4f92-adf0-9f5cb45c61a4
https://ora.ox.ac.uk/objects/uuid:f33dd5f8-0d10-4f92-adf0-9f5cb45c61a4
Autor:
Benedetta Apollonio, Elisabeth Jane Walsby, Piers E.M. Patten, Kirsty Cuthill, Chris Pepper, Linda Barber, Elizabeth H Phillips, Maria Serena Longhi, Christopher Fegan, Eve Coulter, Deborah Yallop, Yun Ma, Andrea G. S. Buggins, Marta Pasikowska, Alan G. Ramsay, Stephen Devereux
Publikováno v:
Pasikowska, M, Walsby, E, Apollonio, B, Cuthill, K M, Phillips, E H, Coulter, E M, Longhi, M S, Ma, Y, Yallop, D, Barber, L D, Patten, P, Fegan, C, Ramsay, A G, Pepper, C, Devereux, S & Buggins, A G S 2016, ' Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration ', Blood, vol. 128, no. 4, pp. 563-573 . https://doi.org/10.1182/blood-2016-01-683128
Pasikowska, M, Walsby, E, Apollonio, B, Cuthill, K, Phillips, E H, Coulter, E, Longhi, M S, Ma, Y, Yallop, D, Barber, L D, Patten, P, Fegan, C, Ramsay, A G, Pepper, C, Devereux, S & Buggins, A G S 2016, ' Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration ', Blood . https://doi.org/10.1182/blood-2016-01-683128
Pasikowska, M, Walsby, E, Apollonio, B, Cuthill, K, Phillips, E H, Coulter, E, Longhi, M S, Ma, Y, Yallop, D, Barber, L D, Patten, P, Fegan, C, Ramsay, A G, Pepper, C, Devereux, S & Buggins, A G S 2016, ' Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration ', Blood . https://doi.org/10.1182/blood-2016-01-683128
Several lines of evidence suggest that homing of tumor cells to lymphoid tissue contributes to disease progression in chronic lymphocytic leukemia (CLL). Here, we demonstrate that lymph node (LN)-derived CLL cells possess a distinct phenotype, and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b106cd2e2412f1265522663bc92364
Autor:
Deborah Yallop, Andrea Pepper née Buggins, K Fishlock, Piers E.M. Patten, Ana Levi, Yolanda Calle, Satyen H. Gohil, Stephen Devereux
Publikováno v:
British Journal of Haematology. 154:216-222
Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are invo
Autor:
Andrew Wotherspoon, Ghulam J. Mufti, Julie Richards, Terry J. Hamblin, Piers E.M. Patten, Andrea G. S. Buggins, Stephen Devereux, Jon Salisbury
Publikováno v:
Blood. 111:5173-5181
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease with a highly variable outcome. The prognosis of patients with CLL may be predicted using a number of biomarkers, including the level of CD38 expression at the leukemic cell surface.
Autor:
Ghulam J. Mufti, Julie Richards, Piers E.M. Patten, N S B Thomas, Stephen Devereux, Andrea G. S. Buggins
Publikováno v:
Leukemia. 22:1084-1087
Chronic lymphocytic leukemia (CLL) is an indolent disorder with a highly variable course whose clinical features arise through the accumulation of tumor cells in the bone marrow, blood and secondary lymphoid tissue. While hematopoietic failure may oc
Autor:
Rafael Duarte, Wendy Ingram, Aloysius Ho, ZiYi Lim, Ronald Brand, M Akthari, Ghulam J. Mufti, Stephen Devereux, D Milojkovic, Antonio Pagliuca
Publikováno v:
Bone Marrow Transplantation. 40:747-752
The presence of clonal gammopathies (CG) has been reported following both conventional myeloablative and autologous haematopoietic stem cell transplantation (HSCT). We monitored the occurrence of CG in a cohort of patients with myeloid malignancies r
Publikováno v:
Leukemia & Lymphoma. 48:290-294
Although myeloid sarcomas (MS) are frequently associated with acute myeloid leukaemia (AML), the occurrence of mediastinal MS is a much rarer event. The authors describe a distinct group of three AML patients with mediastinal MS and complex cytogenet
Autor:
Aleix Gimeno, Stephen Devereux, Anna Parente-Ribes, Audun Os, Bjarne Bogen, Simone Bürgler, Ludvig A. Munthe, Geir E. Tjønnfjord, Dong Wang, Peter Jebsen
Publikováno v:
Journal of immunology (Baltimore Md. : 1950)
Chronic lymphocytic leukemia (CLL) is a B cell malignancy associated with increased levels of inflammatory cytokines. Similarly, expression of CD38 on CLL cells correlates with CLL cell survival and proliferation, but the mechanisms that regulate CD3
Publikováno v:
Leukemia. 19:1699-1702
Tumor supernatant from myeloid malignancies inhibits T-cell apoptosis and cell cycle entry independently