Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rita Sattler"'
Autor:
Thomas E. Mahan, Deepti Lall, David M. Holtzman, Rita Sattler, A.K.M. Ghulam Muhammad, Michael Vazquez, Jesse Landeros, Daniel H. Geschwind, Hayk Davtyan, Ileana Lorenzini, Jacqueline G. O’Rourke, Jason D. Ulrich, Thomas A. Mota, Shaughn Bell, Junwon Kim, Jessica E. Rexach, Layla Ghaffari, Oksana Shelest, Mathew Blurton-Jones, Robert H. Baloh
Publikováno v:
Neuron, vol 109, iss 14
C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins. In addition to AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31b1ab4973804c5e9402cb574f064cf
https://escholarship.org/uc/item/9ws7v673
https://escholarship.org/uc/item/9ws7v673
Autor:
Briggs Carhart, Matthew Chaung, Taylor Wingfield, Sam Macklin-Isquierdo, Gary J. Bassell, Alexander Starr, Ileana Lorenzini, Zachary T. McEachin, Daniela C. Zarnescu, Paul R. August, Robert Bowser, Alexandre Betourne, Nadine Bakkar, Robert Kraft, Nicholas M. Boulis, Nathan Zahler, Justin K. Ichida, Samuel V. Alworth, Benjamin E. Rabichow, Wen-Hsuan Chang, Rita Sattler
Publikováno v:
Neurobiology of Disease, Vol 149, Iss, Pp 105228-(2021)
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders resulting from mutations in the copper transporters ATP7A and ATP7B, with ATP7A mutations also caus
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M Gittings, Deepti Lall, Benjamin E Rabichow, Stephen Moore, Ryan Pevey, Lynette Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F Gendron, Robert H Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Background A mutation in the C9orf72 gene is the most common genetic mutation of familial and sporadic ALS, as well as familial FTD. While prior studies have focused on elucidating the mechanisms of neuronal dysfunction and neurodegeneration associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed9356d12a0c4f704bd87027f5bc041
https://doi.org/10.1101/2020.09.03.277459
https://doi.org/10.1101/2020.09.03.277459
Autor:
Robert S. Rogers, Konrad E. Zinsmaier, Jacob C. Schwartz, Alexander Starr, Daniela C. Zarnescu, Hiroshi Nishimune, Rita Sattler, Ileana Lorenzini, Ching Chieh Chou, Alyssa N. Coyne, Benjamin L. Zaepfel, Meaghan Torvund, Jennifer L. Levy, Wilfried Rossoll, Jeffrey Johannesmeyer
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 110-125 (2017)
Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to ∼97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpression (
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Neurological diseases, including dementias such as Alzheimer's disease (AD) and fronto-temporal dementia (FTD) and degenerative motor neuron diseases such as amyotrophic lateral sclerosis (ALS), are responsible for an increasing fraction of worldwide
Autor:
Yuqing Huo, Rita Sattler, Jeffrey D. Rothstein, Nicholas J. Maragakis, Pentti J. Tienari, Ping Wu Zhang, Amanda M. Haidet-Phillips, Jacqueline T. Pham, Youngjin Lee
Publikováno v:
Glia. 64:63-75
Astrocytes are instrumental to major brain functions, including metabolic support, extracellular ion regulation, the shaping of excitatory signaling events and maintenance of synaptic glutamate homeostasis. Astrocyte dysfunction contributes to numero
Autor:
Sofya Abazyan, Bagrat Abazyan, Eun Ju Yang, Camilo Rojas, Meng Xia, Mikhail V. Pletnikov, Rita Sattler, Chunxia Yang, Barbara S. Slusher
Publikováno v:
Journal of Neuroscience Research. 92:1659-1668
Disrupted-in-schizophrenia 1 (DISC1) is a genetic risk factor that has been implicated in major mental disorders. DISC1 binds to and stabilizes serine racemase to regulate production of D-serine by astrocytes, contributing to glutamate (GLU) neurotra
Autor:
Pentti J. Tienari, Leonard Petrucelli, Nicholas J. Maragakis, Christopher J. Donnelly, Frank Rigo, Rita Sattler, Nipun A. Mistry, Elizabeth L. Daley, Jiou Wang, Aaron R. Haeusler, Erin M. Poth, Jacqueline T. Pham, Svetlana Vidensky, Bryan J. Traynor, Daniel M. Fines, C. Frank Bennett, Jeffrey D. Rothstein, Seth Blackshaw, Ping Wu Zhang, Benjamin Hoover
Publikováno v:
Neuron. 80(2):415-428
SummaryA hexanucleotide GGGGCC repeat expansion in the noncoding region of the C9ORF72 gene is the most common genetic abnormality in familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The function of the C9O
Autor:
Nuno Jorge Lamas, Vernice Jackson-Lewis, Hynek Wichterle, Christopher E. Henderson, Serge Przedborski, Jeffrey D. Rothstein, Alejandro Garcia-Diaz, C. Alan Kachel, Yoon A. Kim, Rita Sattler, Laurent Roybon, Eun Ju Yang
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 1035-1048 (2013)
SummaryDifferentiation of astrocytes from human stem cells has significant potential for analysis of their role in normal brain function and disease, but existing protocols generate only immature astrocytes. Using early neuralization, we generated sp
Autor:
Jeffrey D. Rothstein, Meredith C. Lane, Rita Sattler, Elizabeth N. Krizman, Mausam Ghosh, Michael B. Robinson
The Na(+) -dependent glutamate transporter GLT-1 (EAAT2) shows selective expression in astrocytes, and neurons induce the expression of GLT-1 in astrocytes. In an unpublished analysis of GLT-1 promoter reporter mice, we identified an evolutionarily c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f117483b4b4e6901d532f459f1fddb
https://europepmc.org/articles/PMC4837027/
https://europepmc.org/articles/PMC4837027/