Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Richard Salvi"'
Autor:
Hong Sun, Jeanne M. Manalo, Dalian Ding, John Hicks, Richard Salvi, Fred A. Pereira, Rodney E. Kellems, Yang Xia, Hong Liu
Publikováno v:
The FASEB Journal. 34:15771-15787
Over 466 million people worldwide are diagnosed with hearing loss (HL). About 90% of HL cases are sensorineural HL (SNHL) with treatments limited to hearing aids and cochlear implants with no FDA-approved drugs. Intriguingly, ADA-deficient patients h
Publikováno v:
J Assoc Res Otolaryngol
Temporal resolution is essential for processing complex auditory information such as speech. In hearing impaired persons, temporal resolution, often assessed by detection of brief gaps in continuous sound stimuli, is typically poorer than in individu
Autor:
Dalian Ding, Haibo Shi, Richard Salvi, Yazhi Xing, Jianghui Zhang, Peng Li, Fang Liu, Weidong Qi, Haiyan Jiang, Hong Sun, Shankai Yin
Publikováno v:
Journal of Otology
Journal of Otology, Vol 15, Iss 1, Pp 36-40 (2020)
Journal of Otology, Vol 15, Iss 1, Pp 36-40 (2020)
The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However, little is known about fighting oxidat
Autor:
Richard Salvi, Kelly Radziwon, Guang-Di Chen, Dalian Ding, Benjamin D. Auerbach, Xiaopeng Liu
Publikováno v:
Neuroscience
Noise-induced hearing loss generally induces loudness recruitment, but sometimes gives rise to hyperacusis, a debilitating condition in which moderate intensity sounds are perceived abnormally loud. In an attempt to develop an animal model of loudnes
Autor:
Aaron S. Gomez, Yong Hwan Kim, Thomas C. Foster, Mi-Jung Kim, Christina Rothenberger, Upal Bose, Richard Salvi, Isabela Caicedo, Karessa White, Senthilvelan Manohar, Hyo-Jin Park, Dalian Ding, Masaru Tanokura, Edith M. Sampson, Maria S. Ticsa, Paul J. Linser, Ashok V. Kumar, Shinichi Someya, Takuya Miyakawa, Chul Han, Kevin Boyd
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II deto
Fragile X (FX) syndrome is one of the leading inherited causes of autism spectrum disorder (ASD). A majority of FX and ASD patients exhibit sensory hypersensitivity, including auditory hypersensitivity or hyperacusis, a condition in which everyday so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3da3e17f138f17c26ad24a3ee3bb75
https://doi.org/10.1101/2021.09.25.461569
https://doi.org/10.1101/2021.09.25.461569
Autor:
Senthilvelan Manohar, Haiyan Jiang, Dalian Ding, Xiaopeng Liu, Guang-Di Chen, Richard Salvi, Li Li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
2-Hyroxypropyl-beta-cyclodextrin (HPβCD) is being used to treat Niemann-Pick C1, a fatal neurodegenerative disease caused by abnormal cholesterol metabolism. HPβCD slows disease progression, but unfortunately causes severe, rapid onset hearing loss
Publikováno v:
Neurotox Res
Paraquat, a superoxide generator, can damage the cochlea causing an ototoxic hearing loss. The purpose of the study was to determine if deletion of Bak, a pro-apoptotic gene, would reduce paraquat ototoxicity or if deletion of Sirt3, which delays age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5198635a5e5780e596a3acdf24cd7f64
https://europepmc.org/articles/PMC8277768/
https://europepmc.org/articles/PMC8277768/
Publikováno v:
Neuroscience. 407:135-145
The central auditory system shows a remarkable ability to rescale its neural representation of loudness following long-term, low-level acoustic exposures; even when the noise is presented intermittently. Circadian rhythms exert potent biological effe
Autor:
Tian-Yu Tang, Xiao-Min Xu, Chun-Qiang Lu, Richard Salvi, Gao-Jun Teng, Ying Luan, Yun Jiao, Jian Zhang
Publikováno v:
Neural Plasticity, Vol 2019 (2019)
Neural Plasticity
Neural Plasticity
Abnormal neural activity in the cerebellum has been implicated in hearing impairments, but the effects of long-term hearing loss on cerebellar function are poorly understood. To further explore the role of long-term bilateral sensorineural hearing lo