Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Raymond Rothstein"'
Autor:
Yashaswi Shrestha, Ronald Herbst, Rajiv Raja, Maria Libera Ascierto, Michael Oberst, Philip Martin, Melissa de los Reyes, Nabendu Pore, Raymond Rothstein, John Meekin, Ashok K. Gupta, Melanie M. Frigault, Stephen Blackmore, Ina Bisha, Nathan Standifer, Shaad Essa Abdullah, Theresa Proia, Matthew Griffin, Phillip A. Dennis, Rebecca A. Halpin, Song Wu, Ricardo J Miragaia, Kathy Mulgrew, J. Carl Barrett, Maria Jure-Kunkel
Publikováno v:
Cancer Discovery. 11:2828-2845
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Autor:
Michael Oberst, Kim Rosenthal, James Hair, Catherine Auge, Srinath Kasturirangan, Yanan Zheng, Daniel Freeman, Srinivas Mamidi, Shino Hanabuchi, Francis Neal, Amanda Watkins, Clifford Sachs, Raymond Rothstein, Scott A. Hammond, James Moynihan
Publikováno v:
Cancer Research. 78:2775-2775
Targeted immunotherapy utilizing agonist antibodies (Ab) to OX40 shows great promise in preclinical mouse models alone or in combination with various therapies including PD1/PD-L1 antagonist Abs. Ab-mediated signaling through OX40 requires higher-ord
Autor:
Qihui Huang, Stacy Fuhrmann, Jonathan Rios-Doria, Kelly McGlinchey, Robert E. Hollingsworth, Carl Hay, Edmund Poon, Nick Holoweckyj, Erin Sult, Ching Ching Leow, Ronald Herbst, Gundo Diedrich, Melissa Damschroder, Kris Sachsenmeier, Nicholas M. Durham, Kathy Mulgrew, Raymond Rothstein, Scott A. Hammond
Publikováno v:
Oncoimmunology
MEDI9447 is a human monoclonal antibody that is specific for the ectoenzyme CD73 and currently undergoing Phase I clinical trials. Here we show that MEDI9447 is a potent inhibitor of CD73 ectonucleotidase activity, with wide ranging immune regulatory
Autor:
Stacy Fuhrmann, Edmund Poon, Erin Sult, Kathy Mulgrew, Robert E. Hollingsworth, Raymond Rothstein, Ross Stewart, Carl Hay, Qihui Huang, Kelly McGlinchey, Scott A. Hammond, Kris Sachsenmeier
Publikováno v:
Cancer Research. 75:285-285
MEDI9447 is a monoclonal antibody specific for the ectoenzyme, CD73. Data is presented in support of the hypothesis that targeting the extracellular production of adenosine by CD73 reduces the immunosuppressive effects of adenosine. We report a range