Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nelofer Syed"'
Autor:
Michaela Oblukova, Andreas G. Tzakos, Yiannis Deligiannakis, Romana Sokolová, Nelofer Syed, Dimitrios Galaris, Aikaterini Gemenetzi, Tim Crook, Paraskevi S. Gerogianni, Dimitrios A. Diamantis, Maria V. Chatziathanasiadou, Christina Papaemmanouil
Publikováno v:
Free Radical Biology and Medicine. 160:540-551
Natural antioxidants, like phenolic acids, possess a unique chemical space that can protect cellular components from oxidative stress. However, their polar carboxylic acid chemotype reduces full intracellular antioxidant potential due to limited diff
Autor:
Gregory Sivolapenko, Andreas G. Tzakos, Evgenios K. Stylos, Tim Crook, Nelofer Syed, Maria V. Chatziathanasiadou, Evangelos Briasoulis, Maria-Helen Spyridaki, Haralabos P. Kalofonos, Efstathia Giannopoulou
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 164:690-697
Sunitinib is a multi-targeted tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor and is currently being investigated against other forms of malignant tumors. Recently gre
Publikováno v:
Metabolites
Volume 10
Issue 9
Metabolites, Vol 10, Iss 346, p 346 (2020)
Volume 10
Issue 9
Metabolites, Vol 10, Iss 346, p 346 (2020)
Metabolic regulation of immune cells has arisen as a critical set of processes required for appropriate response to immunological signals. While our knowledge in this area has rapidly expanded in leukocytes, much less is known about the metabolic reg
Publikováno v:
Neuro Oncol
Ketogenic diet (KD) has been proposed as a coadjuvant therapy in the treatment of brain tumours. Reduction of blood glucose and increase in ketone bodies concentration are amongst the most important changes induced by KD in patients. Preliminary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0002095570821fba0871182a31e48426
https://europepmc.org/articles/PMC6789991/
https://europepmc.org/articles/PMC6789991/
Autor:
George Dranitsaris, Justin Stebbing, Tim Crook, Eleftheria Hatzimichael, Reshma Shah, Alexandra Papoudou-Bai, Helen M. Coley, Konstantinos L. Bourantas, Aggeliki Dasoula, Nelofer Syed
Publikováno v:
European Journal of Haematology. 84:47-51
EGLN1 and EGLN3 are members of the egg-laying-defective 9 (EglN) prolyl-hydroxylases which during normoxia catalyse hydroxylation of the hypoxia-inducible factor (HIF)-1alpha, thereby promoting its ubiquitination by a complex containing the von Hippe
Autor:
Alexandra Sullivan, Paul Smith, Beverley Griffin, Paul J. Farrell, Martin J. Allday, Jenny O'Nions, Tim Crook, Lindsay C. Spender, Dorothy H. Crawford, Martin J. S. Dyer, Nelofer Syed, Ingrid Hoffmann, L. Karran
Publikováno v:
Blood. 107:250-256
The Polo-like kinases (Plks) are a highly conserved family of protein kinases that function in regulation of cell cycle and DNA damage-induced checkpoints. Evidence of a tumor suppressor function for the Plks in human neoplasia is lacking. Here, we r
Autor:
Aliki Danou, Nelofer Syed, Margaret J. Dallman, Paul Langridge, David C. J. Carpentier, Laurence Bugeon
Publikováno v:
Journal of the American Society of Nephrology : JASN. 14(3)
Glomerular filtration is one of the primary functions of the kidney. Podocytes, a highly specialized cell type found in glomeruli, are believed to play a critical role in that function. Null mutations of genes expressed in podocytes like WT1, nephrin
Autor:
Tim Crook, Nelofer Syed, Daniel M. Berney, Peter W. Szlosarek, Michael D. Allen, Louise Jones, Nicholas R. Lemoine
Publikováno v:
Clinical Cancer Research. 16:A23-A23
Tumors deficient in argininosuccinate synthetase (ASS1), a key enzyme involved in arginine synthesis, are auxtrophic for arginine and sensitive to amino acid deprivation. Based on reports of ASS1 negativity and arginine auxotrophy of prostate and ren
Publikováno v:
Blood. 110:2132-2132
Background: Multiple myeloma (MM) results from an excess of monoclonal plasma cells in the bone marrow. MM cells are interleukin (IL)-6 and stromal cell dependent. Although the molecular signature of MM cells has been identified, the signature of the
Autor:
Justin Stebbing, Mark Bower, Tim Crook, Kikkeri N. Naresh, Paul Smith, Nelofer Syed, Beverly E. Griffin
Publikováno v:
Journal of Clinical Oncology. 25:18540-18540
18540 Background: Transcriptional silencing represents a major mechanism of tumour suppressor gene inactivation in human tumours, including lymphoma. Here, we have compared patterns of aberrant methylation in sporadic and HIV-associated B cell lympho