Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nathan Singh"'
Autor:
Pranali Ravikumar, Michael J. Mitchell, Rui Zhang, Carl H. June, Margaret M. Billingsley, Nathan Singh
Publikováno v:
Nano Lett
Chimeric antigen receptor (CAR) T cell therapy relies on the ex vivo manipulation of patient T cells to create potent, cancer-targeting therapies, shown to be capable of inducing remission in patients with acute lymphoblastic leukemia and large B cel
Autor:
Zev A. Binder, Nathan Singh, J. Joseph Melenhorst, Donald M. O'Rourke, Jun Xu, McKensie A. Collins, Jie Xu, Elena Orlando
Publikováno v:
Semin Cancer Biol
Chimeric antigen receptor (CAR)-engineered T cells have demonstrated remarkable success in the treatment of B cell malignancies. FDA approval of these therapies represents a watershed moment in the development of therapies for cancer. Despite the suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d1da5c7127ea5c41c33829e9f9d8e6
https://europepmc.org/articles/PMC7684646/
https://europepmc.org/articles/PMC7684646/
Publikováno v:
Best Practice & Research Clinical Haematology. 34:101304
Chimeric antigen receptor (CAR) T cells have revolutionized the management of B cell malignancies. These synthetic molecules are composed of peptide fragments from several distinct immune cell proteins and link highly-specific antigen recognition wit
Publikováno v:
Current Hematologic Malignancy Reports. 12:522-529
In this review, we discuss the most recent developments in gene-editing technology and discuss their application to adoptive T cell immunotherapy. Engineered T cell therapies targeting cancer antigens have demonstrated significant efficacy in specifi
Autor:
Olga Shestova, Charly R. Good, Seok Jae Hong, Saar Gill, Carl H. June, Ophir Shalem, Nathan Singh, Marco Ruella, Stephan A. Grupp, Elena Orlando, Pranali Ravikumar, Shelley L. Berger, Karen Thudium Mueller, Matthew D. Weitzman, Katharina E. Hayer
Cellular immunotherapy using T cells engineered to express chimeric antigen receptors targeting CD19 (CART19) leads to long-term remission in patients with B-cell malignancies1–5. Unfortunately, a significant fraction of patients demonstrate primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d634f8e1ff5d086bfeecec8b81dd340
Autor:
David A. Christian, David M. Barrett, Amy Shyu, Saar Gill, Jessica Perazzelli, Pranali Ravikumar, Mohamed Abdel-Mohsen, Noelle V. Frey, Janis K. Burkhardt, Boris Engels, Brian Granda, Marco Ruella, Melissa Ramones, Jennifer Brogdon, Stephan A. Grupp, Linlin Zhao, Nathan Singh, Steven L. Highfill, Florent Colomb, Regina M. Young, Shannon L. Maude, Liaomin Peng, Xeuqing Maggie Lu, Olga Shestova, Nathan H. Roy, Simon F. Lacey, Carl H. June
Publikováno v:
Blood. 134:247-247
We recently conducted a clinical trial of CD22-directed chimeric antigen receptor (CAR) T cells in children and adults with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). While we did observe some transient responses, overall outco
Autor:
Yangbing Zhao, Stephan A. Grupp, Carl H. June, Xiaojun Liu, Nathan Singh, David M. Barrett, Shuguang Jiang
Publikováno v:
Cytotherapy. 16:619-630
Background aims Cytotoxic T lymphocytes modified with chimeric antigen receptors (CARs) for adoptive immunotherapy of hematologic malignancies are effective in pre-clinical models, and this efficacy has translated to success in several clinical trial
Autor:
Zachary Gershenson, David M. Barrett, David T. Teachey, Stephan A. Grupp, Bruce L. Levine, Ted J. Hofmann, Nathan Singh
Publikováno v:
Cytotherapy. 19(7)
Background aims Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 has demonstrated remarkable success in targeting B-cell malignancies but is often complicated by serious systemic toxicity in the form of cytokine release syndrome (CRS). C
Publikováno v:
Science Translational Medicine. 8
Engineered T cell therapies have begun to demonstrate impressive clinical responses in patients with B cell malignancies. Despite this efficacy, many patients are unable to receive T cell therapy because of failure of in vitro expansion, a necessary
Autor:
Utku Kandemir, Omar Bakr, Kiley Libuit, Saam Morshed, Dennis Ren, Meir Marmor, Nathan Singh, Rita E Baumgartner
Publikováno v:
Journal of orthopaedic trauma. 30(2)
Objectives The use of fluoroscopy for indirect guidance in orthopaedic trauma surgery has increased. The purpose of this investigation was to assess how real-time visualization of radiation exposure impacts dose levels during orthopaedic trauma opera