Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Matthew Trotter"'
Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Autor:
Andrew Dervan, Matthew Trotter, Christopher Mark Hill, Brian Fox, Hamid Bolouri, Alexander V. Ratushny, Anne-Renee van der Vuurst de Vries, Joshua Beilke, Pallavur Sivakumar, Paul Shannon, Rebecca Johnson, Mary Young, Lu Huang, Douglas Bassett, C.C. Santini
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Failure to clear antigens causes CD8+ T cells to become increasingly hypo-functional, a state known as exhaustion. We combined manually extracted information from published literature with gene expression data from diverse model systems to infer a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c710102aeb2ce4874d47ec577d38fe37
Autor:
Sasha Mendjan, Tiago Faial, Roger A. Pedersen, Matthew Trotter, Evangelia Diamanti, Andreia S. Bernardo, Daniel Ortmann, Victoria L. Mascetti, James C. Smith, George E. Gentsch
Publikováno v:
Development (Cambridge, England)
The transcription factor brachyury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates. Despite its wide use and importance in stem cell and developmental biology, its functional genomic targets in human cell
Autor:
Michelle Waldman, Hsiling Chiu, Matthew Trotter, Anita Gandhi, Benedetta Apollonio, Patrick Hagner, Anjan Thakurta, Maria Wang, Suzana Couto, Rajesh Chopra, Erin Flynt, Maria Ortiz, Alan G. Ramsay
Publikováno v:
Hagner, P R, Chiu, H, Ortiz, M, Apollonio, B, Wang, M, Couto, S, Waldman, M F, Flynt, E, Ramsay, A G, Trotter, M, Gandhi, A K, Chopra, R & Thakurta, A 2017, ' Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity ', British Journal of Haematology, vol. 179, no. 3, pp. 399-409 . https://doi.org/10.1111/bjh.14866
Lenalidomide is an immunomodulatory agent that has demonstrated clinical benefit for patients with relapsed or refractory mantle cell lymphoma (MCL); however, despite this observed clinical activity, the mechanism of action (MOA) of lenalidomide has
Autor:
Alexander V. Ratushny, Rob Hershberg, Mary Young, Faith E. Davies, Antje Hoering, Frits van Rhee, Adam Rosenthal, Gareth J. Morgan, Matthew Trotter, Bart Barlogie, Brian A Walker, Maurizio Zangari, Mark McConnell, Brian Fox, Katie Newhall, Jake Gockley, Andrew Dervan, Nathan Petty, Michael A Bauer, Wilbert B. Copeland, Samuel A. Danziger, Cody Ashby, Alison Fitch, David J. Reiss, Frank Schmitz, Phil Farmer
Publikováno v:
Blood. 132:1882-1882
Introduction The multiple myeloma (MM) tumor microenvironment (TME) strongly influences patient outcomes as evidenced by the success of immunomodulatory therapies. To develop precision immunotherapeutic approaches, it is essential to identify and enu
Publikováno v:
Nature biotechnology
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental origin-specific SMC subtypes
Autor:
Claire E. Senner, Elizabeth M. Callery, Ashley Moffett, James C. Smith, Kathy K. Niakan, Roger A. Pedersen, Matthew Trotter, Myriam Hemberger, Andreia S. Bernardo, Lucy Gardner, Daniel Ortmann, Lee Bardwell, Tiago Faial
Publikováno v:
Cell Stem Cell
Cell Stem Cell; Vol 9
Cell Stem Cell; Vol 9
SummaryBMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mou
Autor:
Matthew Trotter, Ludovic Vallier, Adrian Kee Keong Teo, Leah A. Vardy, Ray N Dunn, Candy H.-H. Cho, Bing Lim, Roger A. Pedersen, Stephanie Brown, Nicholas R.F. Hannan, Siim Pauklin
Publikováno v:
Stem Cells. 29:1176-1185
Activin/Nodal signaling is necessary to maintain pluripotency of human embryonic stem cells (hESCs) and to induce their differentiation toward endoderm. However, the mechanisms by which Activin/Nodal signaling achieves these opposite functions remain
Autor:
Matthew Trotter, Richard Apps, Victoria Male, Ashley Moffett, N. Miller, R. North, Sandra A. Founds, Andrew M. Sharkey, Lucy Gardner
Publikováno v:
Placenta
We have examined the transcriptional changes associated with differentiation from villous to extravillous trophoblast using a whole genome microarray. Villous trophoblast (VT) is in contact with maternal blood and mediates nutrient exchange whereas e
Autor:
Sarah Moyon, Jeffrey K. Huang, Marie-Claude Potier, Matthew Trotter, Luce Dauphinot, Stéphane Melik Parsadaniantz, Christophe Kerninon, Anne Laure Dubessy, Marie Stephane Aigrot, Robin J.M. Franklin, Catherine Lubetzki
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, 2015, 35 (1), pp.4-20. ⟨10.1523/JNEUROSCI.0849-14.2015⟩
Journal of Neuroscience, 2015, 35 (1), pp.4-20. ⟨10.1523/JNEUROSCI.0849-14.2015⟩
The declining efficiency of myelin regeneration in individuals with multiple sclerosis has stimulated a search for ways by which it might be therapeutically enhanced. Here we have used gene expression profiling on purified murine oligodendrocyte prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883eaa46db78bbfb8cf1421cc7db1434
https://amu.hal.science/hal-04146386/document
https://amu.hal.science/hal-04146386/document