Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karen-Amanda Irvine"'
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
High rates of acute and chronic pain are associated with traumatic brain injury (TBI), but mechanisms responsible for the association remain elusive. Recent data suggest dysregulated descending pain modulation circuitry could be involved. Based on th
Autor:
Karen-Amanda Irvine, Wen-Wu Li, Vivianne L. Tawfik, Xiaoyou Shi, J. David Clark, Tian-Zhi Guo, Peyman Sahbaie, Wade S. Kingery
Publikováno v:
Anesthesiology. 130:292-308
Editor’s PerspectiveWhat We Already Know about This TopicWhat This Article Tells Us That Is NewBackgroundEmerging evidence suggests that opioid use immediately after surgery and trauma may worsen outcomes. In these studies, the authors aimed to det
Autor:
Nikos Kyritsis, Jacqueline C. Bresnahan, Karen-Amanda Irvine, John C. Gensel, Rajiv R. Ratan, Jessica L. Nielson, Michael C. Oldham, J.R. Huie, Mark R. Segal, Michael S. Beattie, Jonathan Z. Pan, Amity Lin, Adam R. Ferguson, Patrick G. Schupp
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
SUMMARYTraumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d88e3e42b981826baf038dde7aa4fd2
https://escholarship.org/uc/item/75d653j4
https://escholarship.org/uc/item/75d653j4
Autor:
Xiaoyou Shi, Anders Christian Meidahl, Yuan Sun, Peng Liu, De-Yong Liang, Karen-Amanda Irvine, Peyman Sahbaie, J. David Clark, David C. Yeomans, Tian-Zhi Guo
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 14-23 (2017)
IBRO Reports
IBRO Reports
Chronic pain after traumatic brain injury (TBI) is very common, but the mechanisms linking TBI to pain and the pain-related interactions of TBI with peripheral injuries are poorly understood. In these studies we pursued the hypothesis that TBI pain s
Publikováno v:
Journal of neurotrauma. 35(13)
Chronic pain is a common consequence of traumatic brain injury (TBI) that can increase the suffering of a patient and pose a significant challenge to rehabilitative efforts. Unfortunately, the mechanisms linking TBI to pain are poorly understood, and
Autor:
Adam R. Ferguson, James W. Grau, Jacqueline C. Bresnahan, Michael S. Beattie, J. Russell Huie, Ellen D. Stuck, Karen-Amanda Irvine, Kuan H. Lee
Publikováno v:
eNeuro, vol 2, iss 5
eNeuro
eNeuro
Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms. Perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a315aa9641201d343cd648b3adde770f
https://escholarship.org/uc/item/8wd9z71h
https://escholarship.org/uc/item/8wd9z71h
Autor:
Karen-Amanda Irvine, Maura Hofstadter, Marion Murray, Kim D. Anderson, Oswald Steward, Kelli Sharp
Publikováno v:
Experimental Neurology. 220:23-33
We describe here a novel forelimb locomotor assessment scale (FLAS) that assesses forelimb use during locomotion in rats injured at the cervical level. A quantitative scale was developed that measures movements of shoulder, elbow, and wrist joints, f
Autor:
David H. Rowitch, Sovann Kaing, Chao Zhao, Dong-in Yuk, Sergio E. Baranzini, Nader Sanai, Karen-Amanda Irvine, Robin J.M. Franklin, Stephen P.J. Fancy
Publikováno v:
Genes & Development. 23:1571-1585
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of
Autor:
J. M. Anderson, David Baker, Gareth Pryce, Siddharthan Chandran, David W. Hampton, Gavin Giovannoni, James W. Fawcett, Alastair Compston, Robin J.M. Franklin, Karen-Amanda Irvine
Publikováno v:
Journal of Neuroimmunology. :200-211
Multiple sclerosis (MS) represents a considerable challenge to experimentally model due to its twin pathologies of inflammatory demyelination and neurodegeneration along with its multifocal and multiphasic nature. Experimental autoimmune encephalomye
Publikováno v:
Journal of the Neurological Sciences. 265:43-46
The relative merits of endogenous and exogenous oligodendrocyte progenitor cells (OPCs) for remyelination are compared in terms of their ability to repopulate OPC-depleted tissue and generate remyelinating oligodendrocytes. Exogenous neonatal OPCs ca