Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joshua Keegan"'
Autor:
Begum Utz, Sabin A. Nettles, Natalia Wojciechowska, Claudio A. Mosse, Maria O'Neill, Jonathan Scher, Joshua Keegan, Emma Y. Gagne, Yan Guo, Lia Barrow, Annette S. Kim, Miao Lin, Amma Bosompem, Catherine E. Alford, Dahai Wang, James A. Lederer, Yahya Daneshbod
Publikováno v:
Am J Pathol
Myelodysplastic syndromes (MDS) are clonal neoplasms of the hematopoietic stem cell that result in aberrant differentiation of hematopoietic lineages caused by a wide range of underlying genetic, epigenetic, and other causes. Despite the myriad origi
Autor:
Khalid Shah, Wenya Linda Bi, Ameen Chaudry, James A. Lederer, Joseph Driver, Joshua Keegan, Nina Cheng, Jasneet Kaur Khalsa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Immunotherapy has emerged as a promising approach to treat cancer, however, its efficacy in highly malignant brain-tumors, glioblastomas (GBM), is limited. Here, we generate distinct imageable syngeneic mouse GBM-tumor models and utilize RNA-sequenci
Autor:
Joshua Keegan, Goro Tajima, Anupamaa J Seshadri, Laura A Cahill, Kazuma Yamakawa, Yasutaka Nakahori, Fei Guo, James A. Lederer
Publikováno v:
J Leukoc Biol
CD4+ regulatory T cells (Tregs) are acutely activated by traumatic injury, which suggests that they may react to injury with similar kinetics as memory T cells. Here, we used a mouse burn trauma model to screen for memory-like T cell responses to inj
Autor:
Shahzad Shaefi, Simon C. Robson, Leo E. Otterbein, Michael B. Yaffe, Anupamaa J Seshadri, James A. Lederer, Carl J. Hauser, Fei Guo, Fan Zhang, Jennifer P Nguyen, Laura A Cahill, Joshua Keegan
Publikováno v:
PMC
Injury
Injury
Background Trauma causes tissue injury that results in the release of damage associated molecular patterns (DAMPs) and other mediators at the site of injury and systemically. Such mediators disrupt immune system homeostasis and may activate multicell
Autor:
Jennifer P Nguyen, James A. Lederer, Stephen E. Alves, Sabrina Bracero, Guoxing Wang, Emma Stevens, Ye Cao, Deepak A. Rao, Lin Chen, Karen H. Costenbader, Yujie Qu, Joshua Keegan, Takanori Sasaki
ObjectiveTo investigate the immune cell profiling and their longitudinal changes in systemic lupus erythematosus (SLE).MethodsWe employed mass cytometry with three different 38-39 marker panels (Immunophenotyping, T cell/monocyte, and B cell) in cryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbdd9358ef339a092bccac580f775788
https://doi.org/10.1101/2021.11.08.467791
https://doi.org/10.1101/2021.11.08.467791
Autor:
Deepak A. Rao, Lin Chen, Karen H. Costenbader, Sabrina Bracero, Stephen E. Alves, Guoxing Wang, Emma Stevens, Takanori Sasaki, Ye Cao, Joshua Keegan, James A. Lederer, Yujie Qu
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Autor:
Joshua Keegan, D. Gallo, Jennifer P Nguyen, Dusan Hanidziar, Leo E. Otterbein, James A. Lederer, Yasutaka Nakahori, Laura A Cahill, Simon C. Robson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Prolonged exposure to hyperoxia has deleterious effects on the lung, provoking both inflammation and alveolar injury. The elements of hyperoxic injury, which result in high rates of lethality in experimental models, are thought to include multicellul
Autor:
Kelvin Xi Zhang, Joel M. Guthridge, Michelle Petri, Stephen E. Alves, Guoxing Wang, Alexandra V. Bocharnikov, Chamith Y. Fonseka, Deepak A. Rao, James A. Lederer, Michael B. Brenner, Michael F. Gurish, Peter A. Nigrovic, Chaim Putterman, Betty Diamond, Arnon Arazi, Gregory Keras, David Wofsy, Ye Cao, Zhihan J. Li, Joshua Keegan, Matthew F. Mackey, Vanessa Sue Wacleche, Yujie Qu, Jennifer H. Anolik, Karen H. Costenbader, Judith A. James, Eric S. Muise, Jill P. Buyon
Publikováno v:
JCI Insight. 4
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic T cell–B cell interactions and autoantibody production. Defining the T cell populations that drive B cell responses in SLE may enable design of therapies that s
Publikováno v:
Cancer Research. 81:1772-1772
Introduction: We developed a unique autologous cellular therapeutic strategy using a proprietary engineered leukocyte stimulator cell lines (ENLIST cells) that express an array of immunomodulatory proteins to activate and expand tumor cell killing ef
Autor:
Gabriel A. Brat, Anupamaa Seshadri, Yasutaka Nakahori, Takeshi Wada, Ali Salim, Carl J. Hauser, Reza Askari, Jennifer P Nguyen, Matt Giangola, Joshua Keegan, Brian K. Yorkgitis, Wei Li, James A. Lederer
Publikováno v:
The journal of trauma and acute care surgery. 87(2)
Trauma induces a complex immune response, requiring a systems biology approach to capture multicellular changes. Using mass cytometry by time-of-flight (CyTOF), we evaluated time-dependent changes in peripheral blood in trauma patients to identify ch