Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Jose R. Conejo-Garcia"'
Autor:
Carmen M. Anadon, Shelley S. Tworoger, Alexander R. A. Anderson, Robert M. Wenham, Ricardo A. Chaurio, Mary K. Townsend, Paulo C. Rodriguez, Xiaoqing Yu, Naoko Sasamoto, Carlos Moran, Andrea L. Buras, Jimena Trillo-Tinoco, Tara Lee Costich, Jose R. Conejo-Garcia, Jessica A. Mine, Subir Biswas, Chandler Gatenbee, Kathryn L. Terry, Kristen E. Rigolizzo, Douglas Marchion, Kyle K. Payne, Gunjan Mandal, Carly M. Harro
Publikováno v:
Nature. 591:464-470
Most ovarian cancers are infiltrated by prognostically relevant activated T cells1–3, yet exhibit low response rates to immune checkpoint inhibitors4. Memory B cell and plasma cell infiltrates have previously been associated with better outcomes in
Autor:
Jude Masannat, Robbert J.C. Slebos, Nelusha Amaladas, Ritu Chaudhary, Juan C. Hernandez-Prera, Xuefeng Wang, Wenjuan Wu, Christine H. Chung, Jose R. Conejo-Garcia, Feifei Song, Keegan P McCleary-Sharpe, Aik Choon Tan, Gerald E Hall
Publikováno v:
Mol Carcinog
Prognosis for patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains poor. Development of more effective and less toxic targeted therapies is necessary for HNSCC patients. Checkpoint kinase 1 (CHK1) plays a vi
Autor:
Alvaro Padron, Tyler J. Curiel, Ryan Reyes, Vincent Hurez, Curtis A. Clark, Justin M. Drerup, Aijie Liu, Harshita Gupta, Xinyue Zhang, Jenny Mendez, Yilun Deng, Jose R. Conejo-Garcia, Srilakshmi Pandeswara, wanjiao chen
Publikováno v:
Cancer Res
The IL2 receptor (IL2R) is an attractive cancer immunotherapy target that controls immunosuppressive T regulatory cells (Treg) and antitumor T cells. Here we used IL2Rβ-selective IL2/anti-IL2 complexes (IL2c) to stimulate effector T cells preferenti
Autor:
Michael Ophir, Qianqian Ming, Gunjan Mandal, Evgenii N. Tcyganov, Carmen M. Anadon, Alfredo Perales-Puchalt, Jennifer Walrath, Michael Schmidt, Paulo C. Rodriguez, Ugur Eskiocak, Carly M. Harro, Douglas C. Marchion, Jessica A. Mine, Ricardo A. Chaurio, Juan R. Cubillos-Ruiz, Subir Biswas, Julia Tchou, Kristen E. Rigolizzo, Brooke T. Mclaughlin, Jose R. Conejo-Garcia, Jason Lajoie, Dmitry I. Gabrilovich, Andrea L. Buras, Piotr Bobrowicz, Tara Lee Costich, Vincent C. Luca, Kyle K. Payne
Publikováno v:
Science. 369:942-949
Gamma delta (γδ) T cells infiltrate most human tumors, but current immunotherapies fail to exploit their in situ major histocompatibility complex-independent tumoricidal potential. Activation of γδ T cells can be elicited by butyrophilin and buty
Autor:
Carmen M. Anadon, Kyle K. Payne, Patricia Swanson, Arindam Bhattacharyya, Jose R. Conejo-Garcia, Subir Biswas, Arnab Gupta, Xiaoqing Yu, Sougata Roy Chowdhury, Gunjan Mandal, Suman Purohit
Publikováno v:
The Journal of Immunology. 203:3447-3460
Tumor-associated macrophages are major contributors to malignant progression and resistance to immunotherapy, but the mechanisms governing their differentiation from immature myeloid precursors remain incompletely understood. In this study, we demons
Autor:
Yu Cao, Shikhar Mehrotra, Eslam Mohamed, David H. Munn, Anthony M. Magliocco, Ling Cen, Rosa A. Sierra, Jose R. Conejo-Garcia, Richard Klar, Carmen M. Anadon, Sven Michel, Juan R. Cubillos-Ruiz, Wenjie Dai, Jimena Trillo-Tinoco, Paulo C. Rodriguez, Douglas C. Marchion, Frank Jaschinski, Richard R. Reich, Tara Lee Costich
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Understanding the intrinsic mediators that render CD8+ T cells dysfunctional in the tumor microenvironment is a requirement to develop more effective cancer immunotherapies. Here, we report that C/EBP homologous protein (Chop), a downstream sensor of
Autor:
Roger Li, Kimberly B. Sprenger, John R. Robinson, Carmen M. Anadon, Bradford A. Perez, Jose R. Conejo-Garcia, Antonio C. Ortiz, Jessica A. Mine, Sneak Peek Administrator, Subir Biswas, John J. Powers, Gunjan Mandal, Sumit Mehta, Tara Lee Costich, Kyle K. Payne, Alexandra Martin, Xiaoqing Yu, Pasquale P. Innamarato, Carlos Moran, Carly M. Harro, Jodi L. Kroeger, Tyler J. Curiel, Paulo C. Rodriguez, Zhitao Wang, Ricardo A. Chaurio, Kristen E. Rigolizzo
Publikováno v:
SSRN Electronic Journal.
Tertiary Lymphoid Structures (TLS) are commonly identified in human tumors with improved outcome, but how they are orchestrated remains elusive. We show that ablation of the genomic organizer SATB1 triggers the polarization of CD4+ T-cells into antig
Autor:
Scott J. Antonia, Robert W. Engelman, Sungjune Kim, Min Liu, Jiqiang Yao, Anders Berglund, John M. Koomen, James J. Mulé, Ben C. Creelan, Min-Hsuan Wang, Nayoung Kim, Bin Fang, Lin Zhang, Jose R. Conejo-Garcia, Cristina Iclozan, Imene Hamaidi, Sean Yoder
Publikováno v:
Regular and young investigator award abstracts.
Background The majority of cancer patients remain refractory to existing cancer immunotherapies. Despite the growing evidence that dysregulated metabolism contributes to the exhaustion of tumor-infiltrating T lymphocytes (TILs) and the loss of their
Autor:
Colin P.N. Dinney, Ryan Putney, Logan Zemp, Jingsong Zhang, Julio M. Pow-Sang, Scott M. Gilbert, Wade J. Sexton, Michael A. Poch, Daniel G. Grass, Young-Chul Kim, Jose R. Conejo-Garcia, James J. Mulé, Shari Pilon-Thomas, Anders Berglund, Jasreman Dhillon, Rohit Jain, Roger Li
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Emerging evidence from studies in sarcoma and melanoma immune checkpoint blockade(ICB) trials demonstrated enhanced efficacy in tumors harbouring tertiary lymphoid structures(TLS)1–3 - lymph node like aggregates in the tumor microenviron
Publikováno v:
Int J Gynecol Pathol
Management options are limited in advanced or recurrent cervical carcinoma. The Food and Drug Administration has recently approved programed cell death-1 (PD-1)/PD-ligand-1 (PD-L1) inhibitors for the treatment of advanced PD-L1 positive cervical canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4279cd0be5a78a14b419e8da31f55f
https://europepmc.org/articles/PMC7010346/
https://europepmc.org/articles/PMC7010346/