Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Hongzhen Li, Peter B. Crino, Wen Li, David H. Gutmann, Erik J. Uhlmann, Jeffrey E. DeClue, Kevin C. Ess
Publikováno v:
Glia. 46:28-40
Individuals with tuberous sclerosis complex (TSC) exhibit a variety of neurologic abnormalities, including mental retardation, epilepsy, and autism. Examination of human TSC brains demonstrate dysplastic astrocytes and neurons, areas of abnormal neur
Autor:
Hongzhen Li, Shaowei Li, Richard Braverman, Douglas R. Lowy, William C. Vass, Jeffrey E. DeClue
Publikováno v:
Molecular Carcinogenesis. 37:98-109
We investigated the effects of overexpression of the tuberous sclerosis-1 and -2 (TSC1/2) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previous
Autor:
Jeffrey E. DeClue, Steven Kaddu, Phuong-Anh Vu, Michael W. Johnson, Matthias Volkenandt, Harry V. Vinters, Christian A. Sander, Heidi Rust, Ingrid Fackler, Ralf Wienecke, Heinz Kutzner, Arno Rütten
Publikováno v:
Journal of Cutaneous Pathology. 30:174-177
Background: Angiofibromas occur sporadically, and they develop in most patients with tuberous sclerosis complex (TSC), which is associated with alterations of the tumor suppressor genes TSC1 or TSC2. Loss of tuberin, the protein product of TSC2, has
Autor:
Ralf Wienecke, Neil A. Swanson, Eckart Klemm, Sarolta Karparti, Jeffrey E. DeClue, Andrew Green
Publikováno v:
Journal of Cutaneous Pathology. 29:287-290
Background: Patients affected with tuberous sclerosis complex (TSC) are prone to the development of multiple benign tumors of the skin and other organs. Tuberin, the protein product of the tuberous-sclerosis-complex-2 tumor suppressor gene (TSC2) has
Autor:
Giovanna Benvenuto, Nancy Ratner, Bo Ling, William C. Vass, David Viskochil, Shaowei Li, Sue C. Heffelfinger, Jeffrey E. DeClue, Wen Rui
Publikováno v:
Journal of Clinical Investigation. 105:1233-1241
We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack E
Publikováno v:
Oncogene. 15:1611-1616
Several inherited predisposition to cancer syndromes are associated with the development of nervous system tumors. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder in which affected individuals are at risk for developing astrocytoma
Autor:
S. Felzmann, D R Lowy, Gangfeng Xu, M. R. Johnson, William C. Vass, R. White, Jeffrey E. DeClue
Publikováno v:
Molecular and Cellular Biology. 14:641-645
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inac
Autor:
A T Look, M B Valentine, Douglas R. Lowy, Berthe M. Willumsen, H. Cen, Jeffrey E. DeClue, Ke Zhang, Alex G. Papageorge, William C. Vass, M. R. Johnson
Publikováno v:
Ciba Foundation Symposium 176-The GTPase Superfamily
We are studying the biological activity and regulation of mammalian Ras protein in tumours and in physiological signalling. We have shown that GAP (the GTPase-activating protein) is a potent negative regulator of normal Ras in cells. Reduction or los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47c0c2231f02e237c275e3c2260b9b2
https://doi.org/10.1002/9780470514450.ch5
https://doi.org/10.1002/9780470514450.ch5
Autor:
Nancy Ratner, Yuan Huang, Tilat A. Rizvi, Jason Bowersock, John Vitullo, Shyra J. Miller, Linda M. Parysek, Gunnar Johansson, Kristine S. Vogel, Hongzhen Li, Jeffrey E. DeClue, Amer Sidani
Publikováno v:
Molecular and cellular biology. 23(6)
Loss of axonal contact characterizes Schwann cells in benign and malignant peripheral nerve sheath tumors (MPNST) from neurofibromatosis type 1 (NF1) patients. Tumor Schwann cells demonstrate NF1 mutations, elevated Ras activity, and aberrant epiderm
Autor:
Shyra J. Miller, Tilat A. Rizvi, Gabrielle deCourten-Myers, Jianqiang Wu, Nancy Ratner, Benjamin C. Ling, Kelly R. Monk, Kristine S. Vogel, Jeffrey E. DeClue, Rania Shamekh
Publikováno v:
Cancer cell. 7(1)
Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications of neurofibromatosis type 1. The epidermal growth factor receptor is not expressed by normal Schwann cells, yet is overexpressed in subpopulations of Nf1 muta