Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jan Meeldijk"'
Autor:
Saskia V. Vijver, Akashdip Singh, Eline T. A. M. Mommers-Elshof, Jan Meeldijk, Ronald Copeland, Louis Boon, Sol Langermann, Dallas Flies, Linde Meyaard, M. Inês Pascoal Ramos
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, and extracellular matrix (ECM). During tumor development, ECM homeostasis is dysregulated. Collagen remodeling by matrix metalloprotein
Autor:
Shuang Li, Christian G. M. van Dijk, Jan Meeldijk, Helena M. Kok, Isabelle Blommestein, Annick L. F. Verbakel, Marit Kotte, Roel Broekhuizen, Miangela M. Laclé, Roel Goldschmeding, Caroline Cheng, Niels Bovenschen
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer. Granzymes are serine proteases stored in the granules of cytotoxic cells, and h
Autor:
Martin Potts, Bernadet Blijenberg, Thomas Stamminger, Adriana Svrlanska, Niels Bovenschen, Astrid Hendriks, Ian J. Groves, Liling Shan, Sara P. H. van den Berg, Jan Meeldijk, Karlijn J. W. M. van Boxtel, Shuang Li, Mark R. Wills
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008426 (2020)
PLoS Pathogens, Vol 16, Iss 4, p e1008426 (2020)
Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d435840b4eae7def284bb4353e27925
Autor:
Stefano Stifani, Mary Anne Potok, Hans Clevers, Jan Meeldijk, Thomas Gridley, Michelle L. Brinkmeier, Sally A. Camper, Kelly B. Cha
Publikováno v:
Molecular Endocrinology. 17:2152-2161
Mutations in the prophet of PIT1 gene (PROP1) are the most common cause of multiple pituitary hormone deficiency in humans; however, the mechanism of PROP1 action is not well understood. We report that Prop1 is essential for dorsally restricted expre
Publikováno v:
Cell Death & Disease
Granzymes are a family of homologous serine proteases involved in inducing apoptosis in virus-infected cells and tumor cells.1, 2 In humans, five granzymes (GrA, GrB, GrH, GrK, and GrM) are expressed, and stored in granules of natural killer (NK) cel
Autor:
Hans Clevers, Garry P. Nolan, Jan Meeldijk, Seppo Vainio, Barbara C. M. van de Weerdt, Petra Moerer, Philippe Jay, Frank J. T. Staal
Publikováno v:
European Journal of Immunology. 31:285-293
T cell factor / lymphocyte enhancer factor (Tcf/Lef) transcription factors complex with the transcriptional co-activator beta-catenin to transduce Wnt signals in a variety of developmental systems. The prototypic family member Tcf-1 is highly express