Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Constance Baer"'
Autor:
Wencke Walter, Claudia Haferlach, Constance Baer, Torsten Haferlach, Wolfgang Kern, Anna Stengel, Manja Meggendorfer
Publikováno v:
Blood Advances
Key Points Comparison of the mutation frequencies and numbers of 122 genes in 3096 cases enables identification of “mutation-driven” entities.Differences in mutation patterns in cases with or without CHIP-associated mutations across entities sugg
Autor:
Manja Meggendorfer, Torsten Haferlach, Martijn W. Heymans, Anna Wojtuszkiewicz, Stephan Hutter, Inge van der Werf, Peter J. M. Valk, Jeroen Janssen, Wolfgang Kern, Constance Baer, Claudia Haferlach, Gert J. Ossenkoppele, Jacqueline Cloos
Publikováno v:
van der Werf, I, Wojtuszkiewicz, A, Meggendorfer, M, Hutter, S, Baer, C, Heymans, M, Valk, P J M, Kern, W, Haferlach, C, Janssen, J J W M, Ossenkoppele, G J, Cloos, J & Haferlach, T 2021, ' Splicing factor gene mutations in acute myeloid leukemia offer additive value if incorporated in current risk classification ', Blood, vol. 5, no. 17, pp. 3254-3265 . https://doi.org/10.1182/BLOODADVANCES.2021004556
Blood advances, 5(17), 3254-3265. American Society of Hematology
Blood Adv
Blood, 5(17), 3254-3265. American Society of Hematology
Blood advances, 5(17), 3254-3265. American Society of Hematology
Blood Adv
Blood, 5(17), 3254-3265. American Society of Hematology
Splicing factor (SF) mutations are important contributors to the pathogenesis of hematological malignancies; however, their relevance in risk classification of acute myeloid leukemia (AML) warrants further investigation. To gain more insight into the
Autor:
Vera Adema, Sven Twardziok, Devlin C Moyer, Wolfgang Kern, Cassandra M Kerr, Courtney E Hershberger, Stephan Hutter, Claudia Haferlach, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Constance Baer, Wencke Walter, Niroshan Nadarajah, Richard A. Padgett, Torsten Haferlach, Manja Meggendorfer
Publikováno v:
Leukemia
Myeloid neoplasms are characterized by frequent mutations in at least seven components of the spliceosome that have distinct roles in the process of pre-mRNA splicing. Hotspot mutations in SF3B1, SRSF2, U2AF1 and loss of function mutations in ZRSR2 h
Autor:
Courtney E Hershberger, Cassandra M Kerr, Vera Adema, Torsten Haferlach, Wencke Walter, Devlin C Moyer, Manja Meggendorfer, Constance Baer, Stephan Hutter, Claudia Haferlach, Richard A. Padgett, Mikkael A. Sekeres, Niroshan Nadarajah, Sven Twardziok, Wolfgang Kern, Jaroslaw P. Maciejewski
Publikováno v:
Leukemia
Myeloid neoplasms are characterized by frequent mutations in at least seven components of the spliceosome that have distinct roles in the process of pre-mRNA splicing. Hotspot mutations in SF3B1, SRSF2, U2AF1 and loss of function mutations in ZRSR2 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4efb49c47d80e3d3b21664c91305540
https://europepmc.org/articles/PMC8312309/
https://europepmc.org/articles/PMC8312309/
Autor:
Giulia Falconi, Maria Teresa Voso, Torsten Haferlach, Tiziana Ottone, Laura Cicconi, Francesco Lo-Coco, William Arcese, Serena Travaglini, Maria Ilaria Del Principe, Constance Baer, Monica Usai, Serena Lavorgna, Valentina Alfonso, Licia Iaccarino, Adriano Venditti, Fabio Forghieri, Mariadomenica Divona, Aleandra Ferrantini
Publikováno v:
American Journal of Hematology. 94:1091-1097
Despite the high probability of cure of patients with acute promyelocytic leukemia (APL), mechanisms of relapse are still largely unclear. Mutational profiling at diagnosis and/or relapse may help to identify APL patients needing frequent molecular m
Autor:
Manja Meggendorfer, Torsten Haferlach, Constance Baer, Stephan Hutter, Wencke Walter, Claudia Haferlach, Wolfgang Kern, Niroshan Nadarajah
Publikováno v:
Blood. 138:3672-3672
Background: The current routine genetic work-up in hematological malignancies includes chromosome banding analysis (CBA) to detect complete or partial chromosomal deletions and fusions, and the identification of point mutations and small deletions or
Autor:
Claudia Haferlach, Yasunobu Nagata, June Takeda, Yoshiko Atsuta, Senji Kasahara, Niroshan Nadarajah, Hiroshi Handa, Masashi Sanada, Wolfgang Kern, Satoru Miyano, Constance Baer, Kenichi Yoshida, Yuichi Shiraishi, Yotaro Ochi, Torsten Haferlach, Shigeru Chiba, Kazuma Ohyashiki, Yasuhito Nannya, Rurika Okuda, Hideki Makishima, Ayana Kon, Seishi Ogawa, Maria Creignou, Tetsuichi Yoshizato, Eva Hellstrom Lindberg
Publikováno v:
Blood. 138:1513-1513
Background Der(1;7)(q10;p10) (der(1;7) is an unbalanced translocation recurrently found in myeloid neoplasms, particularly in myelodysplastic syndromes (MDS) and related disorders. Caused by a recombination between two homologous alphoid sequencing D
Autor:
Anna Maierhofer, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Constance Baer, Claudia Haferlach, Christian Pohlkamp
Publikováno v:
Blood. 136:17-18
Background: In the latest revision of WHO classification (2017) the new category `myeloid neoplasms with germline predisposition´ was introduced. Pathogenic germline (GL) mutations predisposing to hereditary hematological malignancies (HHMs) have be
Autor:
Torsten Haferlach, Niroshan Nadarajah, Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Ilaria Iacobucci, Stanley Pounds, Constance Baer, Lei Shi, Charles G. Mullighan, Chunxu Qu
Publikováno v:
Blood. 134:LBA-4
CG Mullighan and T Haferlach: are co-senior authors Introduction: Recent genomic sequencing studies have advanced our understanding of the pathogenesis of myeloid malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)