Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Claudia Kathe"'
Autor:
Sadaf Soloukey, Andreas Rowald, Claudia Kathe, Ivan Furfaro, Philipp Schonle, Valentina Paggi, Quentin Barraud, Stéphanie P. Lacour, Jimmy Ravier, Qiuting Huang, Kyungjin Kim, Thomas H. Hutson, Ileana O. Jelescu, Antoine Philippides, Noaf Salah Ali Alwahab, Chris I. De Zeeuw, Daniel Huber, Frédéric Michoud, Leonie Asboth, Noe Brun, Jerome Gandar, Grégoire Courtine
Publikováno v:
Nature Biotechnology, 40 (2)
Nature Biotechnology, 40(2), 198-208. Nature Publishing Group
Nature Biotechnology, 40, 198-208. Nature Publishing Group
Nature Biotechnology, 40(2), 198-208. Nature Publishing Group
Nature Biotechnology, 40, 198-208. Nature Publishing Group
Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultr
Autor:
Nicholas D. James, Kang Xiaoyang, Rik Buschman, Aaron A. Phillips, Ian Rigby, Ryan E. Rosentreter, Ileana O. Jelescu, Nicolas Buse, Grégoire Courtine, Jordan W. Squair, Marco Capogrosso, Florian Fallegger, Sean P. Dukelow, Anthony V. Incognito, Jocelyne Bloch, Matthieu Gautier, Steven K. Boyd, Eduardo Martin Moraud, Lois Mahe, Charlotte Moerman, Robin Demesmaeker, YunLong Cheng, Rebecca Charbonneau, Nicolas Vachicouras, Andreas Rowald, Zoe K. Sarafis, Arnaud Bichat, Qin Li, Berkeley A. Scott, Fabien Wagner, Giuseppe Schiavone, Quentin Barraud, Erwan Bezard, Jerome Gandar, Salif Komi, Achilleas Laskaratos, Stéphanie P. Lacour, Newton Cho, Jimmy Ravier, Jan Elaine Soriano, Bita Vaseghi, Philip J. Millar, Kay Bartholdi, Mark Anderson, Laura A. McCracken, Claudia Kathe, Timothy J. Denison
Publikováno v:
Nature
Spinal cord injury (SCI) induces haemodynamic instability that threatens survival1–3, impairs neurological recovery4,5, increases the risk of cardiovascular disease6,7, and reduces quality of life8,9. Haemodynamic instability in this context is due
Autor:
Grégoire Courtine, Randall Pursley, Jordan W. Squair, Kaya J.E. Matson, Daniel E. Russ, Maric D, Anupama Sathyamurthy, Claudia Kathe, Jonathan Krynitsky, Ariel J. Levine, Hua I
After spinal cord injury (SCI), the “spared” tissue below the lesion contains undamaged cells that could support or augment recovery, but targeting these cells requires a clearer understanding of their injury responses and capacity for repair. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca487c35847aa4679943ebbb0a8902ad
https://doi.org/10.1101/2021.04.28.441862
https://doi.org/10.1101/2021.04.28.441862
Autor:
Claudia Kathe, Lawrence D. F. Moon
Publikováno v:
Data in Brief, Vol 21, Iss, Pp 377-385 (2018)
Data in Brief
Data in Brief
Unilateral or bilateral corticospinal tract injury in the medullary pyramids in adult rats causes anatomical and physiological changes in proprioceptive neurons projecting to the cervical spinal cord accompanied by hyperreflexia and abnormal behaviou
Autor:
Michael A. Skinnider, Jordan W. Squair, Aaron A. Phillips, Matthieu Gautier, Gioele La Manno, Leonard J. Foster, Kaya J.E. Matson, Thomas H. Hutson, Quentin Barraud, Grégoire Courtine, Ariel J. Levine, Marco Milano, Mark Anderson, Claudia Kathe
Publikováno v:
Nature Biotechnology
Nature biotechnology
Nature biotechnology
The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.
We present Augur, a method to prioritize the cell types most responsive to biological perturbations in single-cell data. Augur employs
We present Augur, a method to prioritize the cell types most responsive to biological perturbations in single-cell data. Augur employs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566fec5e14436db446102dd90be0967b
https://doi.org/10.1101/2019.12.20.884916
https://doi.org/10.1101/2019.12.20.884916
Autor:
Lawrence D. F. Moon, Claudia Kathe
Unilateral or bilateral corticospinal tract injury in the pyramids of adult rats causes changes in proprioceptive axon terminal arborization in the cervical spinal cord accompanied by hyperreflexia and abnormal movements including spasms [1, 2]. Trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b235308c4c012c3fc3e5533f3460064b
Publikováno v:
Gene Therapy. 23:231-236
Adeno-associated viral (AAV) vectors are one of the most promising gene delivery systems to the central nervous system. We now report, that AAV1 can be used to express transgenes trans-neuronally in neurons distant from the injection site. Specifical
Publikováno v:
eLife, Vol 5 (2016)
eLife
Kathe, C, Hutson, T H, McMahon, S B & Moon, L D F 2016, ' Intramuscular Neurotrophin-3 normalizes low threshold spinal reflexes, reduces spasms and improves mobility after bilateral corticospinal tract injury in rats ', eLife, vol. 5, e18146, pp. 1-30 . https://doi.org/10.7554/eLife.18146
eLife
Kathe, C, Hutson, T H, McMahon, S B & Moon, L D F 2016, ' Intramuscular Neurotrophin-3 normalizes low threshold spinal reflexes, reduces spasms and improves mobility after bilateral corticospinal tract injury in rats ', eLife, vol. 5, e18146, pp. 1-30 . https://doi.org/10.7554/eLife.18146
Brain and spinal injury reduce mobility and often impair sensorimotor processing in the spinal cord leading to spasticity. Here, we establish that complete transection of corticospinal pathways in the pyramids impairs locomotion and leads to increase
Autor:
Pietro Fratta, Jean-Marc Gallo, Boris Rogelj, Claire Troakes, Zupunski, Agnes L. Nishimura, Tibor Hortobágyi, Christopher Shaw, Michael Howell, Claudia Kathe
Publikováno v:
Brain. 133:1763-1771
Trans-activation response DNA-binding protein (TDP-43) accumulation is the major component of ubiquitinated protein inclusions found in patients with amyotrophic lateral sclerosis, and frontotemporal lobar degeneration with TDP-43 positive ubiquitina
Autor:
Harold D Shine, Stephen B. McMahon, Claudia Kathe, Qin Chen, Lawrence D. F. Moon, Thomas H. Hutson
Publikováno v:
Journal of Visualized Experiments : JoVE
The corticospinal tract (CST) can be completely severed unilaterally in the medullary pyramids of the rodent brainstem. The CST is a motor tract that has great importance for distal muscle control in humans and, to a lesser extent, in rodents. A unil