Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Cang-Bao Xu"'
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2020 (2020)
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2020 (2020)
Minimally modified low-density lipoprotein (mmLDL) is a risk factor for cardiovascular diseases. The current study explored the effect of mmLDL on the endothelin type A (ETA) receptor in mouse mesenteric arteries in vivo, as well as the role of autop
Publikováno v:
Microvascular Research. 123:42-49
Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the
Publikováno v:
Journal of Pharmacy and Pharmacology. 71:937-944
Objectives The current study aimed to explore whether minimally modified low-density lipoprotein (mmLDL) via tail vein injection upregulates the ETB and α1 receptors in mouse mesenteric arteries by activating the PI3K/Akt pathway. Methods The contra
Autor:
Kun Li, Andong Zhao, Li Xu, Yunting Zhang, Ying Chen, Cang-Bao Xu, Wei Mengqian, Chuan Wang, Zhenhao Huang, Yu Qi, Zhang Yaping, Lian Ting, Fuqiang Liu
Publikováno v:
Toxicology and Applied Pharmacology. 414:115420
As a VEGF-targeting agent, sorafenib has been used to treat a number of solid tumors but can easily lead to adverse vascular effects. To elucidate the underlying mechanism, rat mesenteric arteries were subjected to organ cultured in the presence of d
Autor:
Jie Lin, Xu-Ping Qing, Enqi Liu, Cang-Bao Xu, Wang Junjie, Jie Li, Lei Cao, Gen Chen, Si-Yu Liu
Publikováno v:
Journal of Vascular Research. 53:58-71
Minimally modified low-density lipoprotein (mmLDL) is a well-known risk factor for cardiovascular diseases. The present study was designed to investigate the role of mmLDL in the endothelium-dependent relaxation of mouse mesenteric arteries. A sensit
Publikováno v:
Molecular Medicine Reports
Low-density lipoprotein receptors (LDLRs) may serve a role in the diabetogenic effect of statins; however, the effects of statins on LDLR expression and its regulation in the pancreas and islets have yet to be determined. To exclude the long-term eff
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 8 (2017)
Frontiers in Pharmacology, Vol 8 (2017)
Numerous studies have noted that populations treated with statins have increased risk for new-onset diabetes mellitus; however, the underlying molecular mechanisms are not fully understood. Interesting, familial hypercholesterolemia patients with mut
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 84
Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases (CVDs). Endothelin type B (ETB) receptors were involved in the pathogenesis of CVDs. However, Sirtuin 1(Sirt1) has potential protect roles for CVDs. The present study was
Publikováno v:
Experimental and therapeutic medicine. 12(4)
Resveratrol (Res) is a specific agonist of sirtuin 1, and has many cardioprotective effects. Although Res is able to relax various vascular beds, its pharmacological properties in rat superior mesenteric arteries and the underlying mechanism are not
Publikováno v:
Journal of Pharmacy and Pharmacology. 62:315-322
Objectives This study was designed to compare vascular contractile and relaxing responses to G-protein coupled receptor agonists among the different regions of arteries following heat stress in rats. Methods Heat exposure was performed by increasing