Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Manal F. Abdelmalek, Jeongeun Hyun, Steven R. Patierno, Rebecca Caffrey, Cynthia A. Moylan, Muthana Al Abo, Anna Mae Diehl, Xiyou Zhou, Seh-Hoon Oh, Arun J. Sanyal, Kun Xiang, Rajesh Kumar Dutta, Raquel Maeso-Díaz, Jennifer A. Freedman
Publikováno v:
J Hepatol
Background & Aims Non-alcoholic fatty liver disease (NAFLD), the hepatic correlate of the metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic inflammation is thought to be the root cause of all these diseases,
Autor:
Tianyi Chen, Jeongeun Hyun, Ali Ahmadi, Hidekazu Tsukamoto, Zhaoli Sun, Kuo Du, Ullas V. Chembazhi, Anna Mae Diehl, Ivan Rusyn, Sushant Bangru, Auinash Kalsotra
Publikováno v:
J Clin Invest
Severe alcoholic hepatitis (SAH) is a deadly liver disease without an effective medical therapy. Although SAH mortality is known to correlate with hepatic accumulation of immature liver cells, why this occurs and how it causes death are unclear. Here
Autor:
Valentin Gogonea, George D. Dalton, Amanda L. Brown, Anna Mae Diehl, Seh-Hoon Oh, Stephanie Zhang, Preeti Pathak, Camelia Baleanu-Gogonea, Linda Tang, Venkateshwari Varadharajan, J. Mark Brown
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103089-(2021)
Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sens
Autor:
Rajesh Kumar Dutta, Seh-Hoon Oh, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Kuo Du, Anna Mae Diehl, Tianai Sun
Publikováno v:
Liver Int
Background & aims The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluat
Liver is one of the few organs with immense regenerative potential even at adulthood in mammals. It is composed of primarily two cell types: hepatocytes and cholangiocytes, that can trans-differentiate to one another either directly or through interm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5749d0f1b1ec3c7f7913f7df6e5b49
https://doi.org/10.1101/2021.04.22.440352
https://doi.org/10.1101/2021.04.22.440352
Autor:
Andrea G. Nackley, Wolfgang Liedtke, Anna Mae Diehl, Huiping Ding, Andreas E. Kremer, Johannes Morstein, Ana E. López-Romero, Qian Zeng, Zilong Wang, Ru-Rong Ji, Qiaojuan Zhang, Yong Chen, Xin Zhang, Piotr Milkiewicz, Tony E. Reeves, Sara L. Morales-Lázaro, Jennifer Y. Zhang, Marcin Krawczyk, Tamara Rosenbaum, Mei-Chuan Ko, Frank Lammert, Andrey V. Bortsov, Manal F. Abdelmalek, Michele Yeo, Huanghe Yang, Carlene Moore, Ying-Ai Jin
Publikováno v:
Gastroenterology. 161(1)
Background & Aims Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Meth
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 22 (2020)
JCI Insight, Vol 5, Iss 22 (2020)
Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its mass while sustaining essential metabolic functions. How the liver balances dual demands for increased proliferative activity with maintenance of organ f
Autor:
Jason Gibson, David S. Hsu, Jeongeun Hyun, Anna Mae Diehl, Simon G. Gregory, Richard T. Premont, Cynthia D. Guy, Mark L. Jewell, Kuo Du, Seh-Hoon Oh, Thomas J. Ribar
Publikováno v:
Am J Pathol
Fibrolamellar carcinoma (FLC) is characterized by in-frame fusion of DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1) with protein kinase cAMP-activated catalytic subunit α (PRKACA) and by dense desmoplasia. Surgery is the only effective tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7b8fb52946e0d6a93a78c380043659
https://europepmc.org/articles/PMC10069284/
https://europepmc.org/articles/PMC10069284/
Background and AimsLiver fibrosis develops in the context of excessive oxidative stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate cells (HSCs). Ferroptosis is a type of regulated cell death that can be caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef9c6e3dd3130b4a811e359e407a456
https://doi.org/10.1101/2019.12.23.886259
https://doi.org/10.1101/2019.12.23.886259