Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Akiyuki Fujii"'
Publikováno v:
Xenobiotica. 38:482-495
1. The purpose of this study was to evaluate drug clearance measured by the metabolic intrinsic clearance (CL(int)) in a substrate depletion assay in comparison with the in vivo clearance (CL(tot)) observed in adjuvant-induced arthritis (AA) rats. 2.
Autor:
Atsushi Kawase, Hiroshi Komura, Masahiro Iwaki, Makiko Negoro, Miki Ishikubo, Ryosuke Akai, Akiyuki Fujii
Publikováno v:
Drug metabolism and pharmacokinetics. 23(3)
This study aimed to clarify the differences in mRNA levels of cytochrome P450 (CYP) isoforms and nuclear receptors between Dark Agouti (DA) and Sprague-Dawley (SD) rats which are animal models for poor metabolizers and extensive metabolizers for CYP2