Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ajay Nirula"'
Autor:
Kara W Chew, Paul Klekotka, Charles R Crain, Ajay Nirula, Manish Chandra Choudhary, Justin Ritz, Alan S. Perelson, Joan Dragavon, Joseph J. Eron, Alexander L. Greninger, Judith S. Currier, Carlee Moser, Ruian Ke, Robert W. Coombs, Michael Hughes, Urvi M. Parikh, Eric S. Daar, Davey M. Smith, James P. Flynn, David A. Wohl, Courtney V. Fletcher, Rinki Deo, Arzhang C Javan, Scott F. Sieg, Ruy M. Ribeiro, James Regan, Jonathan Z. Li
Publikováno v:
medRxiv
Resistance mutations to monoclonal antibody (mAb) therapy has been reported, but in the non-immunosuppressed population, it is unclear if in vivo emergence of SARS-CoV-2 resistance mutations alters either viral replication dynamics or therapeutic eff
Autor:
Ajay Nirula, Edward P. Ingenito, Peter J. Sterk, Ian M. Adcock, Dirk E. Smith, Jeanette Bigler, Ratko Djukanovic, Anthony Rowe, Fan Chung, Ana R. Sousa
Publikováno v:
5.3 Allergy and Immunology.
Background: FEV1 correlates with symptoms and exacerbation risk in asthma. Although considered an index of airway resistance (R), FEV1 also varies with vital capacity (VC) as a function of airway recruitment. Aims: Quantify the contributions of airwa
Publikováno v:
The Journal of Experimental Medicine
CD28 plays a critical role in T cell immune responses. Although the kinase Akt has been shown to act downstream of CD28 in T helper (Th)1 cytokine induction, it does not induce Th2 cytokines such as interleukin 4 (IL-4). We recently reported that pho
Autor:
Evan Beckman, Tatiana Plavina, Norm Allaire, Michelle Petri, Ajay Nirula, Jaya Goyal, Jadwiga Bienkowska, Megan Weaver, Alice Thai, Charlotte Newman, Jeffrey L. Browning
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112545 (2014)
PLoS ONE
PLoS ONE
A subset of patients with autoimmune diseases including rheumatoid arthritis (RA) and lupus appear to be exposed continually to interferon (IFN) as evidenced by elevated expression of IFN induced genes in blood cells. In lupus, detection of endogenou
Autor:
Daniel M. Bloomfield, Carolyn M. Hustad, Ajay Nirula, Joanna Z. Peng, Julie DeMartino, Keith Gottesdiener, Lisa A. Beck, Lisa Hickey, David E. Gutstein, Smita Abbi, Paul Rothenberg, John A. Wagner
Publikováno v:
Biomarkers in medicine. 6(4)
Aims: To characterize monocyte response in a delayed-type hypersensitivity reaction to intradermal tetanus toxoid (TT) injection. Materials & methods: Men with positive serum anti-tetanus titers were stratified by last TT vaccination. Subjects were a
Autor:
Luke Barron, Pietro G. Andres, Ajay Nirula, Ali Sadra, Abul K. Abbas, Kimberly C. Howland, Lawrence P. Kane, Arthur Weiss, Douglas Dresnek, John B. Imboden
Publikováno v:
Nature immunology. 5(4)
CD28 costimulation is essential for CD4(+) T cell proliferation, survival, interleukin 2 (IL-2) production and T helper type 2 development. To define the nature of the signals that may drive different T cell responses, we have done a structure-functi