Zobrazeno 1 - 10
of 146
pro vyhledávání: '"M. Allen"'
Autor:
Joelle Brown, Hannah K. Drescher, Jenna L. Gustafson, Marcos Damasio, Sonu Subudhi, W. Nicholas Haining, David Wolski, Georg M. Lauer, Lucile Massenet-Regad, Maxwell Robidoux, Pierre Tonnerre, Daniel Kvistad, Jihad Aljabban, Arthur Y. Kim, Todd M. Allen, Jasneet Aneja, Lia Laura Lewis-Ximenez, James A. Cheney, Raymond T. Chung, David J. Bean, Damien C. Tully, Nir Hacohen, Nadia Alatrakchi, Thomas Eisenhaure, David J. Lieb, Lea M. Bartsch, Almudena Torres-Cornejo, Ruben C. Hoogeveen, Ang Cui, Debattama R. Sen
Publikováno v:
Nature Immunology. 22:1030-1041
T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasiv
Autor:
Kole T. Roybal, Wendell A. Lim, Cristina Puig-Saus, Vivian P. Garcia, Greg M. Allen, Devan Shah, Antoni Ribas, Gavin E. Shavey, Jasper Z. Williams, Igal S. Sterin, Wei Yu, Jennifer Tsoi, Ki H. Kim
Publikováno v:
Science (New York, N.Y.), vol 370, iss 6520
Science
Science
A logic to cell-cell recognition There has been exciting progress in the field of cancer immunotherapy, which harnesses a patient's own immune system to kill cancer cells. However, achieving precise recognition of cancer cells remains challenging. Ce
Autor:
Bernd H. Zinselmeyer, Thaddeus S. Stappenbeck, David L. Donermeyer, Nathan T. Porter, Samantha Hsieh, Gregory W. Strout, Eric C. Martens, Paul M. Allen, Stephen Horvath, Nan Zhang, Brian Saunders
Publikováno v:
The Journal of Immunology. 204:1035-1046
Bacteria express multiple diverse capsular polysaccharides (CPSs) for protection against environmental and host factors, including the host immune system. Using a mouse TCR transgenic CD4+ T cell, BθOM, that is specific for B. thetaiotaomicron and a
Autor:
Ildefonso Sánchez-Cerrillo, Alfranca A, Serra C, Enrique Martin-Gayo, de los Santos I, M. Calvet-Mirabent, C. Delgado-Arévalo, Maria J. Buzon, Serah Tanno, Maud Deruaz, Vrbanac, Daniel T. Claiborne, Todd M. Allen, García-Fraile L, Sanz J, Alejandro B. Balazs, Muñoz-Fernández Má, Francisco Sánchez-Madrid
Effective function of CD8+ T cells and enhanced innate activation of dendritic cells (DC) in response to HIV-1 is linked to protective antiviral immunity in controllers. Manipulation of DC targeting the master regulator TANK-binding Kinase 1 (TBK1) m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4751ee238d70e24e3f3c61d1dd5764
https://doi.org/10.1101/2021.06.30.450486
https://doi.org/10.1101/2021.06.30.450486
Autor:
David R. Collins, Michael T. Waring, Gaurav D. Gaiha, Olivia Mae Waring, Todd M. Allen, Bruce D. Walker, Karen A. Power, Jonathan M. Urbach, Musie Ghebremichael, Daniel P Worrall, Elizabeth J. Rossin, James Chodosh, Itai Muzhingi, Chioma Nwonu, Melis N. Anahtar, Christian Landeros, Alicja Piechocka-Trocha, Ruchi M. Newman
Publikováno v:
Science. 364:480-484
Structure-based immunogen design Vaccine design for highly mutable pathogens is hindered by a paucity of conserved immunogenic epitopes. Gaiha et al. employed a structure-based technique using network theory to assign scores to protein structure in o
Autor:
Daniel T. Claiborne, Christian L. Boutwell, Timothy Bateson, Meredith Phelps, Radiana Trifonova, James A. Hoxie, Tao Chen, Derrick L. Dopkin, Karen A. Power, Colby R. Maldini, Ken Okawa, George J. Leslie, Xiaochuan Shan, Vladimir Vrbanac, Todd M. Allen, Katharine Krupp, James L. Riley, Serah Tanno
Publikováno v:
Nat Med
An effective strategy to cure HIV will likely require a potent and sustained antiviral T cell response. Here we explored the utility of chimeric antigen receptor (CAR) T cells, expressing the CD4 ectodomain to confer specificity for the HIV envelope,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e502a9bb70766c6db89848aaf0b33a
https://europepmc.org/articles/PMC9422086/
https://europepmc.org/articles/PMC9422086/
Autor:
Matthew H. Spitzer, Breanna M. Allen, Kamir J. Hiam, Yaron Carmi, Anthony Venida, Iliana Tenvooren, Nam Woo Cho, Diana M. Marquez, Rachel DeBarge, Cassandra E. Burnett
Publikováno v:
Nature medicine, vol 26, iss 7
Understanding of the factors governing immune responses in cancer remains incomplete, limiting patient benefit. In this study, we used mass cytometry to define the systemic immune landscape in response to tumor development across five tissues in eigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edac9402d0a8d3ac07a217ae4e100d10
https://escholarship.org/uc/item/9dj6r89z
https://escholarship.org/uc/item/9dj6r89z
Autor:
Rachel DeBarge, Yaron Carmi, Anthony Venida, Cassandra E. Burnett, Breanna M. Allen, Kamir J. Hiam, Matthew H. Spitzer
Harnessing immune defense mechanisms has revolutionized cancer therapy, but our understanding of the factors governing immune responses in cancer remains incomplete, limiting patient benefit. Here, we use mass cytometry to define the organism-wide im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ac0f1f693f427b45dfc09d4118b891
https://doi.org/10.1101/805473
https://doi.org/10.1101/805473
Autor:
J. Michael White, Stephen Horvath, Bernd H. Zinselmeyer, Haiyang Yu, Ashley A. Viehmann Milam, David L. Donermeyer, Vivek Durai, Kenneth M. Murphy, Saravanan Raju, Paul M. Allen, Juliet M. Bartleson, Veronika Redmann
Publikováno v:
The Journal of Immunology. 200:3429-3437
Intricate processes in the thymus and periphery help curb the development and activation of autoreactive T cells. The subtle signals that govern these processes are an area of great interest, but tuning TCR sensitivity for the purpose of affecting T
Autor:
S L Kunkel, Ronald M. Allen, Soichiro Kimura, Melissa Scola, Matthew A. Schaller, Nicholas W. Lukacs
Notch ligands are present during the interactions between T cells and dendritic cells (DC) and induce a myriad of effects that facilitate the activation of T cells, including the induction of T cell regulation, survival, and cytokine production. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd540db06b0bf3c207f1a504d38014b
https://doi.org/10.1101/712430
https://doi.org/10.1101/712430