Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maria Diaz"'
Publikováno v:
Biodrugs
New immuno-oncology therapies are improving cancer treatments beyond the former standard of care, as evidenced by the recent and continuing clinical approvals for immunotherapies in a broad range of indications. However, a majority of patients (parti
Autor:
Gerard J. Nuovo, Timothy Kottke, Kevin J. Harrington, Alan Melcher, Debabrata Mukhopadhyay, Peter Selby, Jill Thompson, Richard G. Vile, Jose S. Pulido, Matthew C. Coffey, Rosa Maria Diaz, Hardev Pandha, Elizabeth Ilett, John D. Chester
Publikováno v:
Molecular Therapy. 19(10):1802-1812
We have previously reported that a burst of vascular endothelial growth factor (VEGF) signaling to tumor-associated endothelium induces a proviral state, during which systemically delivered oncolytic reovirus can replicate in endothelium, thereby ind
Autor:
Jill Thompson, Rosa Maria Diaz, Phonphimon Wongthida, Timothy Kottke, Alan Melcher, Feorillo Galivo, Richard G. Vile
Publikováno v:
Molecular Therapy. 19:150-158
We show here, for the first time to our knowledge, that the antitumor therapy of oncolytic vesicular stomatitis virus (VSV) in the B16ova model depends upon signaling through myeloid differentiation primary response gene 88 (MyD88) in host cells. VSV
Autor:
Scott E. Strome, Timothy Kottke, Phonphimon Wongthida, Candice Willmon, Feorillo Galivo, Richard G. Vile, Jose S. Pulido, John D. Chester, Alan Melcher, Kevin J. Harrington, Rosa Maria Diaz, Peter Selby, Karen M. Kaluza, Glen N. Barber, Jill Thompson
Publikováno v:
Molecular Therapy. 16(12):1910-1918
To protect viral particles from neutralization, sequestration, nonspecific adhesion, and mislocalization following systemic delivery, we have previously exploited the natural tumor-homing properties of antigen-specific CD8+ T cells. Thus, OT-I T cell
Autor:
Jian Qiao, Jay D. Naik, John C. Bell, Hongxun Wang, K.J. Harrington, Kelley Parato, Timothy Kottke, Richard G. Vile, Candice Willmon, Andrew W. Hudacek, Jill Thompson, Rosa Maria Diaz, Alan Melcher, John D. Chester, Peter Selby
Publikováno v:
Gene Therapy. 15:604-616
Although adoptive T-cell therapy has shown clinical success, efficacy is limited by low levels of T-cell trafficking to, and survival in, the immunosuppressive environment of an established tumor. Oncolytic virotherapy has recently emerged as a promi
Autor:
Mikael Valdes, Rosa Maria Diaz, Feorillo Galivo, Glen N. Barber, Phonphimon Wongthida, Timothy Kottke, Richard G. Vile, Jian Qiao, Jill Thompson
Publikováno v:
Cancer Research. 67:2840-2848
Relatively little attention has been paid to the role of virotherapy in promoting antitumor immune responses. Here, we show that CD8+ T cells are critical for the efficacy of intratumoral vesicular stomatitis virus virotherapy and are induced against
Autor:
Jill Thompson, Timothy Kottke, Jose S. Pulido, Rosa Maria Diaz, Richard G. Vile, Feorillo Galivo, Phonphimon Wongthida, Alan Melcher, Larry R. Pease, Kevin D. Pavelko
Innate immune effector mechanisms triggered by oncolytic viruses may contribute to the clearance of both infected and uninfected tumor cells in immunocompetent murine hosts. Here, we developed an in vitro tumor cell/bone marrow coculture assay and us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bbc3b37fe5741984a5c61681073a1a
https://europepmc.org/articles/PMC3896099/
https://europepmc.org/articles/PMC3896099/
Autor:
Fiona Errington, Feorillo Galivo, Tim Kottke, Kevin J. Harrington, Jill Thompson, Lynette Steele, Peter Selby, Elizabeth Ilett, Richard G. Vile, Rosa Maria Diaz, Hardev Pandha, Robin Prestwich, Alan Melcher
Purpose: Reovirus is a naturally occurring oncolytic virus in clinical trials. Although tumor infection by reovirus can generate adaptive antitumor immunity, its therapeutic importance versus direct viral oncolysis is undefined. This study addresses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896ac3b3ccc1ddd199f2a1b343df8b83
https://europepmc.org/articles/PMC4821072/
https://europepmc.org/articles/PMC4821072/
Autor:
Timothy Kottke, Richard G. Vile, Jose S. Pulido, Kevin J. Harrington, Candice Willmon, Peter Selby, Jill Thompson, Rosa Maria Diaz, Matthew C. Coffey, Alan Melcher
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 15(2)
Purpose: The goals of this study were (a) to investigate whether preconditioning of immunocompetent mice with PC-61-mediated regulatory T-cell (Treg) depletion and interleukin-2 (IL-2) would enhance systemic delivery of reovirus into subcutaneous tum