Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David Lyden"'
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz
Autor:
Irina Matei, Jonathan M. Hernandez, DooA Kim, Ayuko Hoshino, David Lyden, William R. Jarnagin, Virginia Pascual, Todd E. Heaton, Serena Lucotti, Gabriel C. Tobias, Kyung A. Kim, Haiying Zhang, Han Sang Kim, Linda Bojmar, Kofi Ennu Gyan, Fanny A. Pelissier Vatter, Zurong Wan, David R. Jones, David P. Kelsen, Tanya M. Trippett, Candia M. Kenific, Michael P. La Quaglia
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 1, Pp 100225-(2021)
STAR Protocols, Vol 2, Iss 1, Pp 100225-(2021)
Summary We developed a modified protocol, based on differential ultracentrifugation (dUC), to isolate extracellular vesicles and particles (specifically exomeres) (EVPs) from various human and murine sources, including cell lines, surgically resected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b22bbd78d2b60c5fa3931c47b9f4e5
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184039
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184039
Autor:
Mithat Gonen, Milica Tesic Mark, Ronald P. DeMatteo, Michael I. D’Angelica, Gokce Askan, T. Peter Kingham, Olca Basturk, Henrik Molina, Bruno Costa-Silva, Constantinos P. Zambirinis, Jonathan M. Hernandez, William R. Jarnagin, Linda Bojmar, David Lyden, Peter J. Allen, Elke J. A. H. van Beek, Alexandre Doussot, Jian Zheng
Background Exosomes are nanovesicles that have been shown to mediate carcinogenesis in pancreatic ductal adenocarcinoma (PDAC). Given the direct communication of pancreatic duct fluid with the tumor and its relative accessibility, we aimed to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008f77154cb09a219404989d7ef9bd99
https://europepmc.org/articles/PMC6779041/
https://europepmc.org/articles/PMC6779041/
Autor:
Wenjing Li, David Lyden, Sara R. Guariglia, Deborah Brancho, Raymond Y L Yu, Chi Wing Chow, Craig L. Bennett, Héctor Peinado, Hong Zhu, James L. Salzer
Publikováno v:
Molecular Biology of the Cell
Mutations in the protein SIMPLE account for the rare autosomal-dominant demyelination in type 1C CMT patients (CMT1C). SIMPLE plays a role in the production of exosomes. Dysregulated endosomal trafficking and changes in exosome-mediated intercellular
Autor:
Joshua Mitchell Weiss, Han Sang Kim, Annette Becker, David Lyden, Basant Kumar Thakur, Héctor Peinado
Publikováno v:
Cancer cell. 30(6)
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and m
Publikováno v:
Seminars in Cancer Biology. 21:139-146
Metastasis is a multistep process that requires acquisition of malignant cell phenotypes which allow tumor cells to escape from the primary tumor site. Each of the steps during metastatic progression involves co-evolution of the tumor and its microen
Autor:
Caitlin Williams, Kavita Mallya, Saya H. Ebbesen, Gonçalo Rodrigues, Henrik Molina, Irina Matei, Ayuko Hoshino, Annette Becker, William R. Jarnagin, Bruno Costa-Silva, Yujie Huang, Milica Tesic Mark, Inger Marie Bowitz Lothe, Nicole M. Aiello, Michael A. Hollingsworth, Tang-Long Shen, Guillermo García-Santos, Till Martin Theilen, Elin H. Kure, Yonathan Ararso, Haiying Zhang, Robert E. Schwartz, Alexandre Doussot, Allyson J. Ocean, Basant Kumar Thakur, Jonathan M. Hernandez, Knut Jørgen Labori, Paul M. Grandgenett, David Lyden, Ben Z. Stanger, Swarnima Singh, Maneesh Jain, Jenny Xiang, Tuo Zhang, Héctor Peinado, Jacqueline Bromberg, Surinder K. Batra
Publikováno v:
Nature cell biology. 17(6)
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC-derived exosomes in
Autor:
Basant Kumar Thakur, Haiying Zhang, Annette Becker, Irina Matei, Yujie Huang, Bruno Costa-Silva, Yan Zheng, Ayuko Hoshino, Helene Brazier, Jenny Xiang, Caitlin Williams, Ruth Rodriguez-Barrueco, Jose M Silva, Weijia Zhang, Stephen Hearn, Olivier Elemento, Navid Paknejad, Katia Manova-Todorova, Karl Welte, Jacqueline Bromberg, Héctor Peinado, David Lyden
Publikováno v:
Cell Research
The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recoverin
Publikováno v:
Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication ISBN: 9781461436966
Exosomes and microvesicles are small spherical membrane fragments shed by several cell types during physiological processes. Increasing attention has been focused on the role of exosomes in malignant progression and metastasis. This chapter highlight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf1ef26aa712d91b6bda7d40a9001e4
https://doi.org/10.1007/978-1-4614-3697-3_9
https://doi.org/10.1007/978-1-4614-3697-3_9
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Autor:
Mary S. Brady, Guillermo García-Santos, Maša Alečković, Héctor Peinado, Paul B. Chapman, Karen Badal, Rosandra N. Kaplan, Caitlin Williams, Caitlin Hoffman, David Lyden, Gema Moreno-Bueno, Marta Hergueta-Redondo, Jedd D. Wolchok, Margaret K. Callahan, Vilma R. Martins, Johan Skog, Jianda Yuan, Ayuko Nitadori-Hoshino, Yibin Kang, Simon Lavotshkin, Cyrus M. Ghajar, Irina Matei, Benjamin A. Garcia, Jacqueline Bromberg, Bruno Costa-Silva
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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El pdf del artículo es el manuscrito de autor.-- et al.
Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human su
Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human su