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Autor:
Patrick M. Dougherty, Jacob Solis, Amina M. Illias, Hongmei Zhang, Juan P. Cata, Kai-Jie Yu, Seon-Hee Hwang, Jose F. Velasquez
Publikováno v:
Pain. 163:923-935
Activation of toll-like receptor 4 (TLR4) in the dorsal root ganglion (DRG) and spinal cord contributes to the generation of paclitaxel-related chemotherapy-induced peripheral neuropathy (CIPN). Generalizability of TLR4 signaling in oxaliplatin-induc
Autor:
Akio Ido, Makoto Matsukubo, Shun Onishi, Mayu Matsui, Satoshi Ieiri, Mitsuru Muto, Toshio Harumatsu, Kotaro Kumagai, Tatsuru Kaji, Waka Yamada, Masakazu Murakami, Keisuke Yano, Koji Yamada, Koshiro Sugita, Ayaka Nagano
Publikováno v:
Pediatric Surgery International
Purpose Total parental nutrition (TPN) causes gastrointestinal mucosal atrophy. The present study investigated the effects of hepatocyte growth factor (HGF) on the intestinal mucosal atrophy induced by TPN. Methods Rats underwent jugular vein cathete
Publikováno v:
European Journal of Pain. 25:2266-2277
BACKGROUND Exposure to stressful experiences is often accompanied by suppressing pain perception, referred to as stress-induced analgesia. The neuropeptides orexins are essential in regulating the mechanism that responds to stressful and painful stim
Autor:
Tomomi Matsuura, Takeshi Tobiume, Etsuko Uematsu, Tomoya Hara, Takayuki Ise, Shusuke Yagi, Tetsuzo Wakatsuki, Takeshi Soeki, Koji Yamaguchi, Daiju Fukuda, Kenya Kusunose, Masataka Sata, Hirotsugu Yamada
Publikováno v:
Circulation Journal. 85:1383-1391
Background Activated factor X (FXa), which contributes to chronic inflammation via protease-activated receptor 2 (PAR2), might play an important role in atrial fibrillation (AF) arrhythmogenesis. This study aimed to assess whether PAR2 signaling cont
Autor:
Masaki Ryuzaki, Asuka Uto, Hiroyuki Inoue, Hiroshi Itoh, Aika Hagiwara, Masaaki Sato, Kenichiro Kinouchi, Takuma Oshida, Kentaro Fujii, Kazutoshi Miyashita, Sho Endo
Publikováno v:
Journal of Hypertension
Background The renal tissue renin--angiotensin system is known to be activated by salt loading in salt-sensitive rats; however, the response in other organs remains unclear. Method Spontaneously hypertensive rats were subjected to normal tap water or
Publikováno v:
ESC Heart Failure, Vol 8, Iss 3, Pp 1979-1989 (2021)
ESC Heart Failure
ESC Heart Failure
Aims Prostaglandin E2 (PGE2) is involved in the development of cardiac hypertrophy. However, whether PGE2 regulates the chronic kidney disease‐associated cardiac hypertrophy and the tentative mechanism remains to be elucidated. Methods and results
Publikováno v:
Behavioral Neuroscience. 135:359-368
We previously reported that the dorsal raphe nucleus (DRN) was involved in the regulation of maternal care in lactating female mice. The DRN receives multiple innervations from a variety of the brain regions. Corticotropin-releasing factor (CRF) Type
Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 20, Pp 240-250 (2021)
Current Issues in Molecular Biology
Volume 43
Issue 1
Pages 20-250
Current Issues in Molecular Biology
Volume 43
Issue 1
Pages 20-250
Chronic adrenergic stimulation is the dominant factor in impairment of the β-cell function. Sustained adrenergic exposure generates dysregulated insulin secretion in fetal sheep. Similar results have been shown in Min6 under the elevated epinephrine
Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F963-F971
Psychotropic drugs may be associated with hyponatremia, but an understanding of how they induce water retention in the kidney remains elusive. Previous studies have postulated that they may increase vasopressin production in the hypothalamus without
Publikováno v:
Brain Research Bulletin. 168:45-51
Background Prostaglandin E2 (PGE2) binds to four receptor subtypes (EP1, EP2, EP3 and EP4) and plays an important role in response to stress. However, the identity of the receptor(s) responsible for PGE2 regulation of neuronal activity and signaling