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Publikováno v:
Pakistan Journal of Biological Sciences. 24:72-79
Background and objective Carisoprodol is a relaxant muscular-skeleton associated with sore muscles and appropriate studies have not been performed on carisoprodol effects on fetuses and mothers. This study has been conducted to clarify the treatment
Autor:
Hasan Caliskan, Metin Bastug, Deniz Billur, Goktug Omercioglu, Firat Akat, Şule Kizil, Belgin Can, Pinar Bayram, Hakan Fiçicilar
Publikováno v:
Experimental Physiology. 107:42-57
What is the central question of this study? We evaluated the effects of diabetes and exercise on lipopolysaccharide-induced acute lung injury. By providing a comprehensive analysis of redox status, blood gases and histological parameters, we aimed to
Autor:
L. Pivackova, Jan Klimas, Zuzana Kmecova, Eva Velasova, Peter Krenek, E. Malikova, Simona Trubacova, Peter Balis, Gabriel Doka
Publikováno v:
Clinical and Experimental Hypertension. 44:101-112
Background Caveolin-1 (cav-1) plays a role in pulmonary arterial hypertension (PAH). Monocrotaline (MCT)-induced PAH is characterized by a loss of cav-1 in pulmonary arteries; however, less is known regarding its role in the hypertrophied right ventr
Autor:
Murat Celik, Selim Safali, Ummuhan Abdulrezzak, Hakan Cebeci, Bahattin Kerem Aydin, Memduha Aydin, Umran Egilmez
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-5 (2021)
Journal of Orthopaedic Surgery and Research
Journal of Orthopaedic Surgery and Research
Purpose The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model. Methods Sixte
Autor:
Ekram Nemr Abd Al Haleem, Sawsan Abo Bakr Zaytoon, Fatma Al –Zahraa Mohamed Ibrahim, Hossam M.M. Arafa
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:864-874
Peptic ulcers are one of the world's major gastrointestinal disorders, embracing both gastric and duodenal ulcers, and affecting 10% of the world population. The current study aimed to investigate the possible protective effect of tadalafil and pento
Autor:
Xiaoli Luo, Pedro A. Jose, Caiyu Chen, Xue Gong, Cong Lan, Cheng Yu, Cuimei Hu, Chao Fan, Zaicheng Xu, Chunyu Zeng, Jialiang Wang, Hao Luo
Publikováno v:
Cardiovasc Res
Aims Exposure to maternal diabetes is associated with increased prevalence of hypertension in the offspring. The mechanisms underlying the prenatal programming of hypertension remain unclear. Because endoplasmic reticulum (ER) stress plays a key role
Autor:
Masaki Ryuzaki, Asuka Uto, Hiroyuki Inoue, Hiroshi Itoh, Aika Hagiwara, Masaaki Sato, Kenichiro Kinouchi, Takuma Oshida, Kentaro Fujii, Kazutoshi Miyashita, Sho Endo
Publikováno v:
Journal of Hypertension
Background The renal tissue renin--angiotensin system is known to be activated by salt loading in salt-sensitive rats; however, the response in other organs remains unclear. Method Spontaneously hypertensive rats were subjected to normal tap water or
Autor:
Cheryl Dowell, Zhenjian Lin, Baldomero M. Olivera, Ronald W. Hughen, Randall T. Peterson, Albebson L. Lim, Jie Zhang, Kevin Chase, J. Michael McIntosh, Noemi D. Paguigan, Lee S. Leavitt, Eric W. Schmidt, Shrinivasan Raghuraman, Manju Karthikeyan, Christopher A. Reilly, Cassandra E. Deering-Rice, Jortan O. Tun, Alan R. Light
Publikováno v:
ACS Chem Neurosci
In our efforts to discover new drugs to treat pain, we identified molleamines A-E (1-5) as major neuroactive components of the sea slug, Pleurobranchus forskalii, and their prey, Didemnum molle, tunicates. The chemical structures of molleamines were
Autor:
William C. Wimley, Camille R. T. Bourgeois, Jing He, Venkateswara R Gogulamudi, Minolfa C. Prieto, Danielle Y Arita, Ryosuke Satou, Justine Jorgensen, Alexis A. Gonzalez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, inclu
Autor:
Naoya Kakutani, Soichiro Hata, Satoshi Maekawa, Shingo Takada, Hideo Nambu, Yoshikuni Obata, Shintaro Kinugawa, Hikaru Hagiwara, Yoshizuki Fumoto, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Ippei Nakano, Katsuma Yamanashi
Publikováno v:
Experimental Physiology. 106:1785-1793
NEW FINDINGS What is the central question of this study? We questioned whether an angiotensin-converting enzyme (ACE) inhibitor prevents skeletal muscle fibrosis in diabetic mice. What is the main finding and its importance? Administration of ACE inh