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pro vyhledávání: ''
Autor:
Patrick M. Dougherty, Jacob Solis, Amina M. Illias, Hongmei Zhang, Juan P. Cata, Kai-Jie Yu, Seon-Hee Hwang, Jose F. Velasquez
Publikováno v:
Pain. 163:923-935
Activation of toll-like receptor 4 (TLR4) in the dorsal root ganglion (DRG) and spinal cord contributes to the generation of paclitaxel-related chemotherapy-induced peripheral neuropathy (CIPN). Generalizability of TLR4 signaling in oxaliplatin-induc
Autor:
Tomomi Matsuura, Takeshi Tobiume, Etsuko Uematsu, Tomoya Hara, Takayuki Ise, Shusuke Yagi, Tetsuzo Wakatsuki, Takeshi Soeki, Koji Yamaguchi, Daiju Fukuda, Kenya Kusunose, Masataka Sata, Hirotsugu Yamada
Publikováno v:
Circulation Journal. 85:1383-1391
Background Activated factor X (FXa), which contributes to chronic inflammation via protease-activated receptor 2 (PAR2), might play an important role in atrial fibrillation (AF) arrhythmogenesis. This study aimed to assess whether PAR2 signaling cont
Autor:
Lily L. Cao, Prem Kumar, Jiarong Fu, Abdulaziz A. Alzahrani, Demitris Nathanael, Keith L. Brain, Andrew M. Coney, Hayyaf S. Aldossary, Clare J. Ray, Andrew P. Holmes
Publikováno v:
Pflugers Archiv
Carotid body (CB) hyperactivity promotes hypertension in response to chronic intermittent hypoxia (CIH). The plasma concentration of adrenaline is reported to be elevated in CIH and our previous work suggests that adrenaline directly activates the CB
Autor:
Armando Teixeira-Pinto, Isaura Tavares, Ana Costa, Marília Sousa, Steven P. Wilson, Isabel Martins, Carlos Reguenga
Publikováno v:
Anesthesiology. 133:628-644
Background Increased descending pain facilitation accounts for opioid-induced hyperalgesia, but the underlying mechanisms remain elusive. Given the role of µ-opioid receptors in opioid-induced hyperalgesia in animals, the authors hypothesized that t
Autor:
Muneyoshi Okada, Kiko Hori, Shoshiro Okada, Hideyuki Yamawaki, Kengo Matsumoto, Satoshi Kameshima, Atsunori Yamamoto, Naoko Yamaguchi
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 472:673-681
Chemerin is an adipocytokine involved in inflammation and lipid metabolism via G protein-coupled receptor, chemokine-like receptor (CMKLR)1. Since the important nuclei regulating pressure (BP) exist in the brain, we examined the effects of acute intr
Autor:
Paul F. Gratzer, Michael Bezuhly, Jean S. Marshall, Amanda Murphy, Craig Midgen, Colton Boudreau, Terry L. LeVatte
Publikováno v:
Plastic and Reconstructive Surgery. 144:803e-813e
BACKGROUND Angiotensin II engagement of angiotensin II type 1 receptor (AT1R) is implicated in fibrogenesis, with AT1R blockers used clinically to attenuate cardiac and renal fibrosis. The authors tested the hypothesis that the AT1R blocker losartan
Autor:
Andrew J. Mannes, Michael J. Iadarola, Jenny Kim, Fernando A. Vazquez, Amelia J. Loydpierson, Dragan Maric, Mary K. Dougherty, Wallis T. Muhly, Radhika Narasimhan, Matthew R. Sapio, Taichi Goto
Publikováno v:
J Pain
During persistent pain, the dorsal spinal cord responds to painful inputs from the site of injury, but the molecular modulatory processes have not been comprehensively examined. Using transcriptomics and multiplex in situ hybridization, we identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59838bba9936948827ffc42b80722634
https://europepmc.org/articles/PMC9441406/
https://europepmc.org/articles/PMC9441406/
Publikováno v:
Scandinavian journal of painReferences. 22(1)
Objectives The most notable adverse side effects of chronic morphine administration include tolerance and hyperalgesia. This study investigated the involvement of dorsal root ganglion (DRG) protein kinase Cɛ (PKCɛ) expression during chronic morphin
Autor:
Christopher Bishop, Nicole E. Chambers, Katherine Chemakin, Carolyn Saito, Sarah Lefkowitz, Kathryn Lanza
Publikováno v:
Psychopharmacology. 237:155-165
In the majority of Parkinson’s disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of s
Autor:
Imre Kalló, Csaba Fekete, Zsolt Liposits, Csaba Vastagh, Miklós Sárvári, Erik Hrabovszky, Gábor Nyiri, Adam Denes
Publikováno v:
Neuroscience. 405:35-46
Microglia are instrumental for recognition and elimination of amyloid β1–42 oligomers (AβOs), but the long-term consequences of AβO-induced inflammatory changes in the brain are unclear. Here, we explored microglial responses and transciptome-le