Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Richard A, Koup"'
Autor:
Amarendra Pegu, Giulia Fabozzi, Joana Dias, John R. Mascola, Wanwisa Promsote, Cassandra G. Almasri, Richard A. Koup, Lucio Gama, Constantinos Petrovas, John Paul Todd, Jonathan Fintzi, Yoshiaki Nishimura, Mangaiarkarasi Asokan, Kylie March, Malcolm A. Martin, Jeffrey D. Lifson
Publikováno v:
J Clin Invest
Primary HIV-1 infection can be classified into six Fiebig stages based on virological and serological laboratory testing, whereas simian-HIV (SHIV) infection in nonhuman primates (NHPs) is defined in time post-infection, making it difficult to extrap
Autor:
Kapil K. Saharia, Richard A. Koup
Publikováno v:
Cell. 155(3):505-514
During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here, we examine how differences in the
Autor:
Julie E. Ledgerwood, Raphael Gottardo, David Price, Emily C. Smith, Robert T. Bailer, Deborah Persaud, Frank Maldarelli, Emma Gostick, Charla A. Andrews, Ingelise J. Gordon, Barney S. Graham, Martha Nason, Mario Roederer, Ann Wiegand, Selorm Adzaku, Mary F. Kearney, David R. Ambrozak, Richard A. Koup, Joseph P. Casazza, Kathryn Bowman, Mary E. Enama, Carrie Ziemniak
Publikováno v:
The Journal of Infectious Diseases. 207:1829-1840
Background. The licensing of herpes zoster vaccine has demonstrated that therapeutic vaccination can help control chronic viral infection. Unfortunately, human trials of immunodeficiency virus (HIV) vaccine have shown only marginal efficacy.Methods.
Autor:
John R. Mascola, Martha Nason, Richard A. Koup, John Paul Todd, Nelson L. Michael, Xuejun Chen, Kathleen A. McGinnis, Stephen D. Schmidt, Srinivas S. Rao, Jeffrey D. Lifson, Keyun Wang, Amarendra Pegu, Merlin L. Robb, Kathryn E. Foulds, Diane L. Bolton, Valerie Letukas
Combination antiretroviral therapy (cART) administered shortly after human immunodeficiency virus type 1 (HIV-1) infection can suppress viremia and limit seeding of the viral reservoir, but lifelong treatment is required for the majority of patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526be370607294a41016c720d57861e7
https://europepmc.org/articles/PMC4719604/
https://europepmc.org/articles/PMC4719604/
Autor:
Kawthar Machmach, Pompeyo Viciana, Ma Ángeles Muñoz-Fernández, Sara Ferrando-Martinez, Ezequiel Ruiz-Mateos, Richard A. Koup, Manuel Leal, Joseph P. Casazza
Publikováno v:
Journal of Virology. 86:3667-3674
A small fraction of HIV-infected individuals (+ CD57 − CD45RO + ), and Gag-specific polyfunctional CD4 T cells than those observed in NC. In EC, the frequency of polyfunctional Gag-specific CD8 T cells was higher than that observed in RC and NC. RC
Publikováno v:
Annual Review of Medicine. 60:471-484
There is an intense interplay between HIV and the immune system, and the literature is replete with studies describing various immunological phenomena associated with HIV infection. By definition, HIV is the cause of the immunologic findings, for wit
Autor:
David Price, Daniel C. Douek, Linda Wooldridge, Brenna J. Hill, S.A. Migueles, Andrew K. Sewell, Mark Connors, Laura E. Ruff, Richard A. Koup, Jason M. Brenchley, Michael R. Betts, Emma Gostick, Mario Roederer
Publikováno v:
The Journal of Experimental Medicine
The forces that govern clonal selection during the genesis and maintenance of specific T cell responses are complex, but amenable to decryption by interrogation of constituent clonotypes within the antigen-experienced T cell pools. Here, we used poin
Publikováno v:
Annual Review of Immunology. 21:265-304
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive infection of the human immune system that invariably, over the course of years, leads to its destruction and fatal immunodeficiency. Paradoxically, whil
Autor:
James R. Thomasch, Laura P. Hale, Janice M. Massey, Richard A. Koup, Barton F. Haynes, Maria E. Gooding, Daniel C. Douek, Donald B. Sanders, Lloyd J. Edwards, Gregory D. Sempowski, Emma Ciafaloni
Publikováno v:
The Journal of Immunology. 166:2808-2817
The human thymus is required for establishment of the T cell pool in fetal life, but postnatal thymectomy does not lead to immunodeficiency in humans. Because thymectomy in humans is performed for treatment of myasthenia gravis (MG), we have studied
Autor:
Brenna J. Hill, Richard A. Koup, James R. Berenson, Daniel C. Douek, Jason M. Brenchley, Michael R. Betts, Robert Vescio, Robert H. Collins, Lan Zhang
Publikováno v:
The Lancet. 355:1875-1881
Summary Background The potential benefits of haematopoietic stemcell transplantation are tempered by the depletion of T-cells accompanying this procedure. We used a new technique which quantifies the excisional DNA products of T-cell-receptor (TCR) g