Zobrazeno 1 - 10
of 1 426
pro vyhledávání: '"11"'
Autor:
Roido Manavaki, Frank H. Hezemans, Young T. Hong, James B. Rowe, George Savulich, Maura Malpetti, Tim D. Fryer, John T. O'Brien, Julie Wiggins, Jonathan P. Coles, Selena Milicevic Sephton, Istvan Boros, Negin Holland, P. Simon Jones, Franklin I. Aigbirhio
Publikováno v:
Mov Disord
BACKGROUND: Synaptic loss is a prominent and early feature of many neurodegenerative diseases. OBJECTIVES: We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy (PSP) (Richardson's synd
Autor:
Hirokazu Furuya, Toru Iwaki, Naokazu Sasagasako, Satoshi O. Suzuki, Hiroyuki Honda, Shinichiro Mori, Takayuki Taniwaki, Hideomi Hamasaki
Publikováno v:
Neuropathology.
Spastic paraplegia type 11 (SPG11) is the most common autosomal recessive hereditary spastic paraplegia with thinning of the corpus callosum. Spatacsin, a protein encoded by the SPG11 gene, is associated with autophagy. SPG11 patients show spastic pa
Autor:
Khalid Hamid El Hachimi, Tine Deconinck, Alessandro Malandrini, Jean Jacques Martin, Giovanni Stevanin, Anne Sieben, Alexis Brice, Michael Gonzales, Federica Zolfanelli, Stephan Züchner, Peter De Jonghe, Carlo Casali, Frédéric Darios, Chantal Ceuterick-de Groote, Filippo M. Santorelli, Paola S. Denora, Dirk Peeters, Katrien Smets
Publikováno v:
Brain
The most common autosomal recessive spastic paraplegia is caused by mutations in SPG11. Denora et al. report the first postmortem neuropathological analysis of two unrelated patients with SPG11, and demonstrate clinical and pathological overlap betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b428b958b294b1b21cd6136d4fa79bbc
http://hdl.handle.net/11365/998591
http://hdl.handle.net/11365/998591
Publikováno v:
Neuropathology and Applied Neurobiology. 43:154-166
AIMS: To quantify tau pathology of chronic traumatic encephalopathy (CTE) and investigate influence of dot-like lesions (DL), brain region, co-morbidity, and sporting career length. METHODS: Densities of neurofibrillary tangles (NFT), astrocytic tang
In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases
Autor:
Ellen Gelpi, Herbert Budka, Hitoshi Hayakawa, Shuji Izumo, Ryuji Kubota, Hui Qin Xing, Kimiko Izumo
Publikováno v:
Neuropathology. 29:433-442
As the pathogenesis of AIDS dementia complex (ADC), cytokines such as TNF-alpha and IL-1beta have been thought to have toxic effects on CNS cells and induce neuronal cell death. However, many of the discussions have been based on the studies done by
Publikováno v:
Acta Neurologica Scandinavica. 103:360-366
Objectives - This study compares positron emission tomography (PET) using 11 C-deuterium-deprenyl (DED) with PET using 18 F-fluorodeoxyglucose( 18 F-FDG) for examining epileptogenic regions in patients with focal epilepsy. Material and methods - Twen
Autor:
Irina Mader, Jochen Karitzky, Albert C. Ludolph, Karsten Henkel, Jürgen W. Unger, Bernd Neumaier, Michaela Schmid, Gerhard Glatting, G. Bernhard Landwehrmeyer, Sven N. Reske
Publikováno v:
Movement Disorders. 19:817-821
Positron emission tomography (PET) using [11C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglia
Autor:
Jan Versijpt, Guido Slegers, K. Van Laere, Eric Achten, J. De Reuck, Jan Debruyne, Karel Strijckmans, F. De Vos, Rudi Dierckx, J Korf, J Keppens
Publikováno v:
European Journal of Neurology. 10:257-264
Activated microglia are involved in the immune response of multiple sclerosis (MS). The peripheral benzodiazepine receptor (PBR) is expressed on microglia and up-regulated after neuronal injury. [11C]PK11195 is a positron emission tomography (PET) ra
Autor:
Juan C. Troncoso, William E. Klunk, Dean F. Wong, Olga Pletnikova, Richard O'Brien, Christos Davatzikos, Jitka Sojkova, Susan M. Resnick, Chester A. Mathis, Ira Driscoll, Michael A. Kraut, Yun Zhou, Luigi Ferrucci
Publikováno v:
Acta neuropathologica. 124(6)
The definitive Alzheimer's disease (AD) diagnosis requires postmortem confirmation of neuropathological hallmarks-amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs). The advent of radiotracers for amyloid imaging presents an opportunity to i
Publikováno v:
Brain Research. 815:150-153
One-week-old rat pups were subjected to an acute 10 min severe hypoxic–ischemic insult. Over the next 24 h, during the reperfusion period, O4 immunocytochemistry demonstrated that oligodendroblasts underwent degenerative changes that were coinciden