Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Xiong, Xi"'
Publikováno v:
Jichu yixue yu linchuang, Vol 42, Iss 8, Pp 1213-1219 (2022)
Objective To investigate the effect of over-activation of mTORC1 on mouse intestinal epithelial homeostasis by conditional knockout of Depdc5. Methods Mice were divided into Depdc5flox/flox group (control group), Depdc5flox/flox:Villin-Cre group (IKO
Externí odkaz:
https://doaj.org/article/72e306b4f04a4e2a85c48a900d0b3c2b
Autor:
Zegang Ma, Fenfei Gao, Brett Larsen, Ming Gao, Zhihua Luo, Dejie Chen, Xiaokuang Ma, Shenfeng Qiu, Yu Zhou, Junxia Xie, Zheng-Xiong Xi, Jie Wu
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 225-237 (2019)
Background: We have recently reported that activation of cannabinoid type 2 receptors (CB2Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA). Here, we elucidate the underlying mechanisms. Methods: Patch-clamp recordin
Externí odkaz:
https://doaj.org/article/1108c50b81b34c0fbaedec3da0dccecd
Autor:
Qing-Rong Liu, Zheng-Xiong Xi, Mary Kay Lobo, Eliot L. Gardner, Lindsay M. De Biase, Hai-Ying Zhang, Ramesh Chandra, Hui Shen
Publikováno v:
Acta Pharmacol Sin
Cannabinoid CB(2) receptors (CB(2)R) are importantly involved in drug reward and addiction. However, the cellular mechanisms underlying CB(2)R action remain unclear. We have previously reported that cocaine self-administration upregulates CB(2)R expr
Publikováno v:
European Neuropsychopharmacology. 43:38-51
Cannabinoids produce both rewarding and aversive effects in humans and experimental animals. However, the mechanisms underlying these conflicting findings are unclear. Here we examined the potential involvement of CB1 and CB2 receptors in cannabinoid
Publikováno v:
Annu Rev Pharmacol Toxicol
The abuse of illicit psychostimulants such as cocaine and methamphetamine continues to pose significant health and societal challenges. Despite considerable efforts to develop medications to treat psychostimulant use disorders, none have proven effec
Publikováno v:
Neuropsychopharmacology
Cocaine abuse continues to be a serious health problem worldwide. Despite intense research, there is still no FDA-approved medication to treat cocaine use disorder (CUD). In this report, we explored the potential utility of beta-caryophyllene (BCP),
Autor:
Ewa Galaj, Xiao Han, Zheng-Xiong Xi, Bree A. Humburg, Chloe J. Jordan, Yi He, Hui Shen, Guo-Hua Bi
Publikováno v:
The Journal of Neuroscience. 40:8853-8869
Opioid reward has traditionally been thought to be mediated by GABA-induced disinhibition of dopamine (DA) neurons in the VTA. However, direct behavioral evidence supporting this hypothesis is still lacking. In this study, we found that the μ opioid
Autor:
Chloe J. Jordan, Zhi-Bing You, Jianjing Cao, Amy Hauck Newman, Yi He, Zheng-Xiong Xi, Guo-Hua Bi
Publikováno v:
British Journal of Pharmacology. 177:4796-4807
Background and purpose Despite widespread abuse of cocaine, there are no approved treatments for cocaine use disorder. Chronic cocaine use is associated with up-regulated dopamine D3 receptor expression in the brain. Therefore, most D3 -based medicat
Autor:
Catherine A. Schweppe, Jean Lud Cadet, Eliot L. Gardner, Subramaniam Jayanthi, Amy Hauck Newman, Thomas M. Keck, Bruce Ladenheim, Zheng-Xiong Xi, Henriette van Praag, Caitlin Burzynski
Publikováno v:
Psychopharmacology (Berl)
RATIONALE: Abuse of the psychostimulant methamphetamine (METH) can cause long-lasting damage to brain monoaminergic systems and is associated with profound mental health problems for users, including lasting cognitive impairments. Animal models of ME
Publikováno v:
Neuroscience and Biobehavioral Reviews
Highlights • Opioid abuse and overdose have become a national crisis in the USA. • Although several opioid-based pharmacotherapies are available, they are ineffective in long-term relapse prevention. • National Institute on Drug Abuse has liste