Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Weiping Zou"'
Autor:
Erin A. Holcomb, Weiping Zou
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
IL-2 is a pleiotropic cytokine. In this issue of the JCI, Ren et al. report on the development of a low-affinity IL-2 paired with anti–PD-1 (PD-1–laIL-2) that reactivates intratumoral CD8+ T cells, but not CD4+ Treg cells. PD-1–laIL-2 treatment
Externí odkaz:
https://doaj.org/article/3a9e27c86b844a7ba113b8f7f112a808
Autor:
Houjun Xia, Shasha Li, Xiong Li, Weichao Wang, Yingjie Bian, Shuang Wei, Sara Grove, Weimin Wang, Linda Vatan, J. Rebecca Liu, Karen McLean, Ramandeep Rattan, Adnan Munkarah, Jun-Lin Guan, Ilona Kryczek, Weiping Zou
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Tumor-associated macrophages (TAMs) affect cancer progression and therapy. Ovarian carcinoma often metastasizes to the peritoneal cavity. Here, we found 2 peritoneal macrophage subsets in mice bearing ID8 ovarian cancer based on T cell immunoglobulin
Externí odkaz:
https://doaj.org/article/6c9048172d6640499478c9301ae55769
Autor:
Xia Sun, Min Zhang, Mohamad El-Zataari, Stephanie Y Owyang, Kathryn A Eaton, Maochang Liu, Yu-Ming Chang, Weiping Zou, John Y Kao
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74595 (2013)
We have shown that Helicobacter pylori induces tolerogenic programming of dendritic cells and inhibits the host immune response. Toll-like receptors (TLRs) represent a class of transmembrane pattern recognition receptors essential for microbial recog
Externí odkaz:
https://doaj.org/article/7cb77ae4bed44c3daca4a3166fe37368
Publikováno v:
Cellular and Molecular Immunology
The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in t
Autor:
Meredith A. Morgan, Qiang Zhang, Kailiang Zhao, Weiping Zou, Leslie A. Parsels, Theodore S. Lawrence, Long Jiang, Michael D. Green, Rémi Buisson, Xueting Lang, Joshua D. Parsels, Sheryl A. Flanagan
Publikováno v:
Molecular cancer research : MCR, vol 19, iss 9
Mol Cancer Res
Mol Cancer Res
Programmed death-ligand 1 (PD-L1) promotes tumor immune evasion by engaging the PD-1 receptor and inhibiting T-cell activity. While the regulation of PD-L1 expression is not fully understood, its expression is associated with tumor mutational burden
Autor:
Jutaek Nam, Ilona Kryczek, Heng Lin, Chitra Subramanian, James J. Moon, Jing Li, Shuang Wei, Wan Du, Sara Grove, Gaopeng Li, Ton Wang, Mark S. Cohen, Jiajia Zhou, Weiping Zou, Linda Vatan, Marcin Cieslik, Shasha Li, Xiong Li
Publikováno v:
Nature cell biology
Major histocompatibility complex-I (MHC-I) presents tumour antigens to CD8+ T cells and triggers anti-tumour immunity. Humans may have 30,000–60,000 long noncoding RNAs (lncRNAs). However, it remains poorly understood whether lncRNAs affect tumour
Autor:
Shawna Wall, Suzanne R. Thibodeaux, Vincent Hurez, T. L. Whiteside, Lishi Sun, Weiping Zou, Srilakshmi Pandeswara, Michael J. Brumlik, Tyler J. Curiel, Vinh Dao, Ilona Kryczek, Alvaro Padron, Brian B. Barnett, Benjamin J. Daniel, Justin M. Drerup
Publikováno v:
Clinical Cancer Research. 27:3661-3673
Purpose: Immunotherapy treats some cancers, but not ovarian cancer. Regulatory T cells (Tregs) impede anti-ovarian cancer immunity but effective human Treg-directed treatments are lacking. We tested Treg depletion with denileukin diftitox (DD) ± IFN
Autor:
Linda Vatan, Weichao Wang, Angelo Aguilar, Shasha Li, Sara Grove, Xueting Lang, Shaomeng Wang, Jing Li, Ilona Kryczek, Peng Liao, Jiajia Zhou, Yijian Yan, Weimin Wang, Wan Du, Shuang Wei, Gaopeng Li, Weiping Zou, Xiong Li, Jiali Yu, Heng Lin
Publikováno v:
Nature immunology
Targeting the p53-MDM2 pathway to reactivate tumor p53 is a chemotherapeutic approach. However, the involvement of this pathway in CD8+ T cell-mediated antitumor immunity is unknown. Here, we report that mice with MDM2 deficiency in T cells exhibit a
Publikováno v:
Nat Rev Cancer
Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular components and recycles metabolic substrates. In response to stress signals in the tumour microenvironment, the autophagy pathway is altered in tumour cells and imm
Autor:
Linda Vatan, Weiping Zou, Yijian Yan, Weichao Wang, Gaopeng Li, Xiong Li, Jiajia Zhou, Shuang Wei, Grzegorz Wallner, Weimin Wang, Marek Majewski, Wan Du, Jian Zhang, Shasha Li, Sara Grove, Haoyan Chen, Fang Hua, Witold Zgodziński, Jing-Yuan Fang, Peng Liao, Ilona Kryczek
Publikováno v:
Cancer Discovery. 11:1826-1843
Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit IFN and MHC signaling gene mutations and are generally resistant to immunotherapy. In exploring the integrity of IFN and MHC