Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Vivien R. Sutton"'
Autor:
Kate H. Gartlan, Slavica Vuckovic, Karshing Chang, Glen M. Boyle, Vivien R. Sutton, Mark J. Smyth, Melody Cheong, Ping Zhang, Motoko Koyama, Kelli P. A. MacDonald, José Paulo Martins, Christopher E. Andoniou, Joseph A. Trapani, Geoffrey R. Hill, Antiopi Varelias, Greg Kelly, Kate A. Markey, Rachel D. Kuns, Siok-Keen Tey, Mariapia A. Degli-Esposti, Jason Sang Hun Lee, Christian R. Engwerda
Publikováno v:
Cancer Immunology Research. 8:1085-1098
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure respo
Autor:
Effie Mouhtouris, Joseph A. Trapani, Mauro S. Sandrin, Francesco L. Ierino, Vivien R. Sutton, Dale Christiansen, Russell Hodgson
Publikováno v:
Transplant International. 32:1203-1215
We have previously reported that ICOS-Ig expressed locally by a PIEC xenograft induces a perigraft cellular accumulation of CD4+ CD25+ Foxp3+ T cells and specific xenograft prolongation. In the present study we isolated and purified CD4+ CD25+ T cell
Autor:
Sarah Ellis, Ricky W. Johnstone, Kevin Y. T. Thia, Daniel M. Andrews, Ilia Voskoboinik, Amelia J. Brennan, Vivien R. Sutton, Gunnar Pejler, Joseph A. Trapani, Jill Danne, Misty R. Jenkins
Publikováno v:
FEBS Journal. 283:947-961
The anionic proteoglycan serglycin is a major constituent of secretory granules in cytotoxic T lymphocyte (CTL)/natural killer (NK) cells, and is proposed to promote the safe storage of the mostly cationic granule toxins, granzymes and perforin. Desp
Autor:
Kristin K. Brown, Ricky W. Johnstone, Ilia Voskoboinik, John Silke, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Andrew J. Freeman, Paul A. Beavis, Kelly M Ramsbottom, Vivien R. Sutton, Jessica Michie, Lizzy Pijpers, Phil Darcy, Simon J. Hogg, Deborah A. Knight, Jane Oliaro, Najoua Lalaoui
Publikováno v:
Science Immunology. 3
Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of resistance remain poorly defined. We used a series of whole-genome clustered regularly interspaced short palindromic repeat (CRISPR)-based screens performed in vitro
Autor:
Angus P. R. Johnston, Ruby H. P. Law, Joseph A. Trapani, James C. Whisstock, Helen R. Saibil, Jamie A. Lopez, Catherina H. Bird, Natalya Lukoyanova, Olivia Susanto, Misty R. Jenkins, Vivien R. Sutton, Ilia Voskoboinik, Phillip I. Bird
Publikováno v:
Blood. 121:2659-2668
Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating virus-infected and transformed target cells through the perforin-dependent delivery of proapoptotic granzymes. However, the mechanism of granzyme entry into cells remains unr
Autor:
Joseph A. Trapani, Kevin Y. T. Thia, David M. Tarlinton, Vivien R. Sutton, Axel Kallies, Gabrielle T. Belz, Edwin D. Hawkins, Magdalena Hagn
Publikováno v:
The Journal of Immunology. 188:3886-3892
Recently, it has been reported that human B cells express and secrete the cytotoxic protease granzyme B (GrB) after stimulation with IL-21 and BCR cross-linking. To date, there are few clues on the function of GrB in B cell biology. As experimental t
Autor:
Colin M. House, Joseph A. Trapani, Jenny Chia, Annette Ciccone, Ilia Voskoboinik, Phillip K. Darcy, Hideo Yagita, Vivien R. Sutton
Publikováno v:
Blood. 110:1184-1190
Perforin (PRF), a pore-forming protein expressed in cytotoxic lymphocytes, plays a key role in immune surveillance and immune homeostasis. The A91V substitution has a prevalence of 8% to 9% in population studies. While this variant has been suspected
Publikováno v:
Journal of Visualized Experiments.
The serine protease Granzyme B (GzmB) mediates target cell apoptosis when released by cytotoxic T lymphocytes (CTL) or natural killer (NK) cells. GzmB is the most studied granzyme in humans and mice and therefore, researchers need specific and reliab
Autor:
Joseph A. Trapani, Vivien R. Sutton
Publikováno v:
Current Opinion in Immunology. 15:533-543
Granzyme B is a caspase-like serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Major recent advances in our understanding of granzyme B biochemistry, biology and function include an appreciation of its
Publikováno v:
Journal of Immunological Methods. 276:59-68
We compared two methods originally devised to purify cytoplasmic granules from granulocytes for their capacity to produce cytotoxic granules from natural killer cell lines, suitable for use in target cell apoptosis assays. Both methods utilised nitro