Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tohru Sugawara"'
Autor:
Noriko Okumura, Hidenori Akutsu, Tohru Sugawara, Takumi Miura, Youki Takezawa, Akihiro Hosoda, Keiichi Yoshida, Justin K Ichida, Mitsutoshi Yamada, Toshio Hamatani, Naoaki Kuji, Kenji Miyado, Yasunori Yoshimura, Akihiro Umezawa
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout embryogenesis and tissue homeostasis. β-Catenin, encoded by the Ctnnb1 gene, mediates an intra
Externí odkaz:
https://doaj.org/article/043296df482f44cb8877cb30e7e9b803
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43277 (2012)
Chimpanzees (Pan troglodytes) have region-specific difference in dietary repertoires from East to West across tropical Africa. Such differences may result from different genetic backgrounds in addition to cultural variations. We analyzed the sequence
Externí odkaz:
https://doaj.org/article/b18643706b38459bbcea29a8d53a9c9f
Autor:
Justin K. Ichida, Jesse D. Lai, Gabriel R. Linares, Shu-Ting Hung, Tohru Sugawara, Shaoyu Lin, Gabriel Rocha, Yingxiao Shi, Kim A. Staats, Carina Seah, Michael Chickering, Yaoming Wang, Berislav V. Zlokovic, Abhay P. Sagare
Publikováno v:
JCI insight. 5
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with diverse etiologies. Therefore, the identification of common disease mechanisms and therapeutics targeting these mechanisms could dramatically improve clinical outcomes. To this
Autor:
Gabriel R. Linares, Justin K. Ichida, Yingxiao Shi, Brandon B Ge, Yichen Li, Jacob Komberg, R. Jeroen Pasterkamp, Davide Trotti, Valerie Hennes, Leonard H. van den Berg, Nicole Koutsodendris, Jason A. Chen, Kaitlin P. Sandor, Vamshidhar R. Vangoor, Louise Menendez, Amy R. Nelson, Michael E. Ward, Tze-Yuan Cheng, Yaoming Wang, Phillip E. Woolwine, Wen-Hsuan Chang, Ketharini Senthilkumar, Kim A. Staats, Mickey Huang, Carina Seah, Alice Zhang, Chris Grunseich, Esther Y. Son, Eric Hendricks, Michael J. Cowan, Paul R. August, Kassandra Kisler, Shih Jong J. Lee, Marcelo P. Coba, Shu Ting Hung, Shaoyu Lin, Brent Wilkinson, N. Wisniewski, Berislav V. Zlokovic, Tohru Sugawara, T. Grant Belgard, Victor Hanson-Smith, Xinmei Wen
Publikováno v:
Nature Medicine, 24(3), 313. Nature Publishing Group
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b18c3fd3677e0457e409e74f97ed0
https://dspace.library.uu.nl/handle/1874/364200
https://dspace.library.uu.nl/handle/1874/364200
Autor:
Julie A. Schneider, Zhen Zhao, Qingyi Ma, Ethan A. Winkler, Anita Ramanathan, Takahiro Maeda, Ashim Ahuja, Justin K. Ichida, Carol A. Miller, Pan Kong, Matthew R. Halliday, Guojun Bu, Takahisa Kanekiyo, Sanket V Rege, Manami Maeda, Tohru Sugawara, Berislav V. Zlokovic, Donghui Zhu, Kassandra Kisler, Abhay P. Sagare, Nelly Chuqui Owens, Gabriel Si
Publikováno v:
Nature neuroscience
PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficie
Autor:
Kenji Miyado, Takumi Miura, Hidenori Akutsu, Masakazu Machida, Mohan C. Vemuri, Seiichi Kanzaki, Akihiro Umezawa, Mayu Yamazaki-Inoue, Tohru Sugawara, Mahendra S. Rao, Naoko Nakamura, Takashi Ohkura
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 1, Iss C, Pp 18-29 (2015)
Regenerative Therapy, Vol 1, Iss C, Pp 18-29 (2015)
The potential applications of human embryonic stem cells (hESCs) in regenerative medicine and developmental research have made stem cell biology one of the most fascinating and rapidly expanding fields of biomedicine. The first clinical trial of hESC
Publikováno v:
Biochemistry. 40:914-919
To gain insight into the origin of the difference in isoelectric point (pI) values for wild-type human interleukin-2 (IL-2) and IL-2 with an additional methionine residue at the N-terminus (Met-IL-2), conformational properties of the two molecular fo
Autor:
Kiyoaki Ouchi, Hidemaro Ono, Tohru Sugawara, Jyunichi Mikuni, Tsuneaki Fujiya, Yoichiro Kakugawa, Yasuhiko Kamiyama, Koujin Endoh
Publikováno v:
The Japanese Journal of Gastroenterological Surgery. 30:1699-1705
加齢に伴う胃癌の臨床病理学的特徴の変化と手術成績を検討した. 切除例を49歳以下 (若年群, 511例), 50~69歳 (中年群, 1,476例), 70歳以上 (高齢群, 363例) に分けると加齢に伴い占居部位では
Autor:
Junnichi Mikuni, Ikuro Sato, Kiyoaki Ouchi, Yoichiro Kakugawa, Takahiko Ohgoshi, Tohru Sugawara, Yasuhiko Kamiyama, Tsuneaki Fujiya, Hiroo Tateno
Publikováno v:
The Japanese Journal of Gastroenterological Surgery. 29:732-736
症例は79歳の女性. 食欲不振を主訴に近医を受診し胃癌と診断され当院へ入院した. 左季肋部に手拳大の腫瘤を触れ腫瘍マーカーはAFP: 990ng/ml, CEA: 6-8ng/mlを示した. 胃X線および内視鏡検査で
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e43277 (2012)
PLoS ONE, Vol 7, Iss 8, p e43277 (2012)
Chimpanzees (Pan troglodytes) have region-specific difference in dietary repertoires from East to West across tropical Africa. Such differences may result from different genetic backgrounds in addition to cultural variations. We analyzed the sequence