Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Todd L. Edwards"'
Autor:
Elizabeth A. Jasper, Jacklyn N. Hellwege, Joseph H. Breeyear, Brenda Xiao, Gail P. Jarvik, Ian B. Stanaway, Kathleen A. Leppig, Geetha Chittoor, M. Geoffrey Hayes, Ozan Dikilitas, Iftikhar J. Kullo, Ingrid A. Holm, Shefali Setia Verma, Todd L. Edwards, Digna R. Velez Edwards
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Preeclampsia, a pregnancy complication characterized by hypertension after 20 gestational weeks, is a major cause of maternal and neonatal morbidity and mortality. Mechanisms leading to preeclampsia are unclear; however, there is evidence of
Externí odkaz:
https://doaj.org/article/593f321d88b040258ab9f27c654b2a15
Autor:
Jeewoo Kim, Ariel Williams, Hannah Noh, Megan M. Shuey, Todd L. Edwards, Digna R. Velez Edwards, Jacklyn N. Hellwege
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 128-129 (2024)
OBJECTIVES/GOALS: Uterine fibroids are benign tumors of the uterus with a high disease prevalence and burden, yet there are few multi-ancestry genetic studies. This is the largest and most diverse fibroid GWAS to-date. Our goal is to identify novel g
Externí odkaz:
https://doaj.org/article/d875c36e29194fe6a46c0f0328562f8b
Autor:
Catherine Anne Greene, Gabrielle Hampton, Gail P. Jarvik, Bahram Namjou-Khales, Atlas Khan, Yuan Luo, Todd L. Edwards, Digna R. Velez Edwards, Jacklyn N. Hellwege
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 13-13 (2024)
OBJECTIVES/GOALS: We aimed to conduct an updated genome-wide meta-analysis of keloids in expanded populations, including those most afflicted by keloids. Our overall objective was to improve understanding of keloid development though the identificati
Externí odkaz:
https://doaj.org/article/9ecc5cf5b0fa4a678f8946cb245c092f
Autor:
Elizabeth A. Jasper, Jacklyn N. Hellwege, Jacqueline A. Piekos, Sarah H. Jones, Katherine E. Hartmann, Brian Mautz, David M. Aronoff, Todd L. Edwards, Digna R. Velez Edwards
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The placenta is critical to human growth and development and has been implicated in health outcomes. Understanding the mechanisms through which the placenta influences perinatal and later-life outcomes requires further investigation. We eval
Externí odkaz:
https://doaj.org/article/811a5d94ec764a988035dd8d2f7a3f0c
Autor:
Megan M. Shuey, Kyung Min Lee, Jacob Keaton, Nikhil K. Khankari, Joseph H. Breeyear, Venexia M. Walker, Donald R. Miller, Kent R. Heberer, Peter D. Reaven, Shoa L. Clarke, Jennifer Lee, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104674- (2023)
Summary: Background: The identification of new uses for existing drug therapies has the potential to identify treatments for comorbid conditions that have the added benefit of glycemic control while also providing a rapid, low-cost approach to drug (
Externí odkaz:
https://doaj.org/article/0a32e0fd304d4bea90a5c225732f57ca
Autor:
Nikhil K. Khankari, Jacob M. Keaton, Venexia M. Walker, Kyung Min Lee, Megan M. Shuey, Shoa L. Clarke, Kent R. Heberer, Donald R. Miller, Peter D. Reaven, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104038- (2022)
Summary: Background: Maintaining a healthy lifestyle to reduce type 2 diabetes (T2D) risk is challenging and additional strategies for T2D prevention are needed. We evaluated several lipid control medications as potential therapeutic options for T2D
Externí odkaz:
https://doaj.org/article/40b062220d4c4983bd63137c4ba814a9
Autor:
Elvis Akwo, Cassiane Robinson-Cohen, Cecilia P. Chung, Peter W.F. Wilson, Christopher O’Donnell, Todd L. Edwards, Csaba P. Kovesdy, Adriana Hung
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 36-36 (2020)
OBJECTIVES/GOALS: African-Americans have a 3-fold higher risk of end-stage kidney disease (ESKD) compared to Whites due in part to APOL1 risk alleles. Whether resistant hypertension (RH) magnifies the risk of ESKD among African Americans beyond APOL1
Externí odkaz:
https://doaj.org/article/e514af7023834987ae38bd2a18d2c77f
Autor:
Gerard A. J. Morris, Digna R. Velez Edwards, Philip C. Hill, Christian Wejse, Cyrille Bisseye, Rikke Olesen, Todd L. Edwards, John R. Gilbert, Jamie L. Myers, Martin E. Stryjewski, Eduardo Abbate, Rosa Estevan, Carol D. Hamilton, Alessandra Tacconelli, Giuseppe Novelli, Ercole Brunetti, Peter Aaby, Morten Sodemann, Lars Østergaard, Richard Adegbola, Scott M. Williams, William K. Scott, Giorgio Sirugo
Publikováno v:
PLoS ONE, Vol 6, Iss 2 (2011)
Externí odkaz:
https://doaj.org/article/536cfe94626a407fba9242d02f136b58
Autor:
Elizabeth A. Jasper, Todd L. Edwards, Jacklyn N. Hellwege, Digna R. Velez Edwards, Eric S. Torstenson, Sarah H. Jones, Jacob M. Keaton
Publikováno v:
Human Genetics. 140:1433-1440
Uterine fibroids disproportionately impact Black women. Evidence suggests Black women have earlier onset and higher cumulative risk. This risk disparity may be due an imbalance of risk alleles in one parental geographic ancestry subgroup relative to
Autor:
Michael G. Levin, Neil M Davies, Julie Lynch, Pradeep Natarajan, Todd L. Edwards, Philip S. Tsao, Daniel J. Rader, Dipender Gill, Benjamin F. Voight, Kyung Min Lee, Derek Klarin, Kyong-Mi Chang, Venexia M Walker, Scott M. Damrauer, Themistocles L. Assimes, Jacklyn N. Hellwege, J. Michael Gaziano, Adriana M. Hung, Jacob M. Keaton
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: We aimed to estimate the effect of blood pressure (BP) traits and BP-lowering medications (via genetic proxies) on peripheral artery disease. Approach and Results: Genome-wide association studies summary statistics were obtained for BP, pe