Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Thomas C. Foster"'
Autor:
Yang Yang, Sahana Manohar-Sindhu, Thomas C. Foster, Daohong Zhou, Dmitry O. Traktuev, Yonghan He, Vivekananda Budamagunta
Publikováno v:
Aging (Albany NY)
Aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm. We hypothesized that senescent cells (SnCs) play a central role in this age-associated pathology in part due to their expressio
Autor:
Marcelo Febo, Luis M. Colon-Perez, Thomas C. Foster, Jolie D. Barter, Ashok V. Kumar, Asha Rani
Publikováno v:
Molecular Neurobiology. 57:4045-4059
Markers of brain aging and cognitive decline are thought to be influenced by peripheral inflammation. This study compared the effects of repeated lipopolysaccharide (LPS) treatment in young rats to age-related changes in hippocampal-dependent cogniti
Autor:
Aaron S. Gomez, Yong Hwan Kim, Thomas C. Foster, Mi-Jung Kim, Christina Rothenberger, Upal Bose, Richard Salvi, Isabela Caicedo, Karessa White, Senthilvelan Manohar, Hyo-Jin Park, Dalian Ding, Masaru Tanokura, Edith M. Sampson, Maria S. Ticsa, Paul J. Linser, Ashok V. Kumar, Shinichi Someya, Takuya Miyakawa, Chul Han, Kevin Boyd
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II deto
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 13 (2021)
Frontiers in Aging Neuroscience, Vol 13 (2021)
There is a critical window for estrogen replacement therapy, beyond which estradiol (E2) fails to enhance cognition and N-methyl-D-aspartate (NMDA) receptor function, and E2-responsive transcription decreases. Much less attention has been given to th
Publikováno v:
Neurobiology of Aging. 70:184-193
A redox-mediated decrease in N-methyl-D-aspartate (NMDA) receptor function contributes to psychiatric diseases and impaired cognition during aging. Inflammation provides a potential source of reactive oxygen species for inducing NMDA receptor hypofun
Publikováno v:
Brain Behav Immun
Autor:
Leah Phan, Wolfgang J. Streit, Maia Martcheva, Alexandra Bechtle, Fatemeh Shaerzadeh, Maxwell Dacquel, Duan Tu, Thomas C. Foster, William Hachmeister, Ashok V. Kumar, Douglas R. Miller, Carissa A. Hansen, Habibeh Khoshbouei
Publikováno v:
Glia
During aging humans lose midbrain dopamine neurons, but not all dopamine regions exhibit vulnerability to neurodegeneration. Microglia maintain tissue homeostasis and neuronal support, but microglia become senescent and likely lose some of their func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba39c4c8faa7946a445f767de75907f3
https://europepmc.org/articles/PMC8356201/
https://europepmc.org/articles/PMC8356201/
Autor:
Thomas C. Foster, Ashok V. Kumar
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 11 (2020)
Frontiers in Endocrinology, Vol 11 (2020)
In the hippocampus, estrogen regulates gene transcription linked to neuronal growth, neuroprotection, and the maintenance of memory function (1–3). The mechanism is likely to involve genomic regulation through classic estrogen receptor (ER) signali
Autor:
Marcelo Febo, Asha Rani, Brittney Yegla, Jolie Barter, Ashok Kumar, Christopher A. Wolff, Karyn Esser, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
The current longitudinal study examined factors (sex, physical function, response to novelty, ability to adapt to a shift in light/dark cycle, brain connectivity), which might predict the emergence of impaired memory during aging. Male and female Fis
Autor:
Maisha Akbar, Zhaoyi Chen, Adam J. Woods, Jian-Guo Bian, Andrew O’Shea, Asha Rani, François Modave, Thomas C. Foster, Eric C. Porges, Ronald A. Cohen, Joseph M. Gullett
Publikováno v:
Neurobiol Aging
The expression of micro-RNA (miRNA) is influenced by ongoing biological processes, including aging, and has begun to play a large role in the measurement of neurodegenerative processes in central nervous system. The purpose of this study was to utili