Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Taylor B. Cavazos"'
Autor:
Taylor B. Cavazos, Linda Kachuri, Rebecca E. Graff, Jovia L. Nierenberg, Khanh K. Thai, Stacey Alexeeff, Stephen Van Den Eeden, Douglas A. Corley, Lawrence H. Kushi, Regeneron Genetics Center, Thomas J. Hoffmann, Elad Ziv, Laurel A. Habel, Eric Jorgenson, Lori C. Sakoda, John S. Witte
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Up to one of every six individuals diagnosed with one cancer will be diagnosed with a second primary cancer in their lifetime. Genetic factors contributing to the development of multiple primary cancers, beyond known cancer syndro
Externí odkaz:
https://doaj.org/article/0d504290c7dd4cca98989c8be7a2c3c4
Autor:
Linda Kachuri, Stephen S. Francis, Maike L. Morrison, George A. Wendt, Yohan Bossé, Taylor B. Cavazos, Sara R. Rashkin, Elad Ziv, John S. Witte
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-18 (2020)
Abstract Background Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic o
Externí odkaz:
https://doaj.org/article/7936984e0ac04210a8fc9f30e8ea6ce0
Autor:
Clint L Cario, Rebecca E. Graff, John S. Witte, David S. Aaronson, Eric Jorgenson, Linda Kachuri, Nima C. Emami, Lori C. Sakoda, Pui-Yan Kwok, Stephen K. Van Den Eeden, Simon Wong, Nirupa R. Ghai, Mark N. Kvale, Caroline G. Tai, Eunice Wan, Joel Mefford, Joseph C. Presti, Chun Chao, Sara R. Rashkin, Catherine Schaefer, Taylor B. Cavazos, Jun Shan, Dilrini K. Ranatunga, Laurel A. Habel, Neil Risch, Thomas J. Hoffmann
Publikováno v:
Cancer research, vol 81, iss 7
To identify rare variants associated with prostate cancer susceptibility and better characterize the mechanisms and cumulative disease risk associated with common risk variants, we conducted an integrated study of prostate cancer genetic etiology in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa857af84a1ce3c6bd4d8d996979fc6f
https://escholarship.org/uc/item/29p4t404
https://escholarship.org/uc/item/29p4t404
Autor:
Maruta A. Blatchins, Stephen K. Van Den Eeden, Caroline G. Tai, Lawrence H. Kushi, John S. Witte, Lancelote Leong, Taylor B. Cavazos, Travis J. Meyers, Rebecca E. Graff, Douglas A. Corley, Stacey E. Alexeeff, Linda Kachuri, Khanh K. Thai, Thomas J. Hoffmann, Eric Jorgenson, Joshua D. Hoffman, Elad Ziv, Lori C. Sakoda, Sara R. Rashkin, Laurel A. Habel, Nima C. Emami
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15285feb7cdbfef25a8a53413e0b989
https://escholarship.org/uc/item/2x39f6df
https://escholarship.org/uc/item/2x39f6df
Autor:
Maike Morrison, George A. Wendt, Sara R. Rashkin, Elad Ziv, John S. Witte, Stephen S. Francis, Taylor B. Cavazos, Linda Kachuri, Yohan Bossé
Publikováno v:
Genome Medicine
medRxiv
article-version (status) pre
article-version (number) 2
Genome medicine, vol 12, iss 1
Genome Medicine, Vol 12, Iss 1, Pp 1-18 (2020)
medRxiv
article-version (status) pre
article-version (number) 2
Genome medicine, vol 12, iss 1
Genome Medicine, Vol 12, Iss 1, Pp 1-18 (2020)
Background Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic opportunit
Autor:
Zun Zar Chi Naing, Maru Jaime-Garza, Taia S. Wu, Laurel S Estes, Martin Kampmann, Eric D. Chow, Taylor B. Cavazos, Miriam A. Goldman, Yessica K. Gomez, William F. DeGrado, Stephanie A. Wankowicz, Matthew C. Johnson, Christa Caggiano, Christina A. Stephens, Bryan Faust, Daniel Barrero, Lakshmi E. Miller-Vedam, Elizabeth E. McCarthy, Kyle E. Lopez, Sy Redding, Jenna Pellegrino, Elissa A Fink, Wren Saylor, Alison M Maxwell, Hayarpi Torosyan, Jared Lumpe, Robert W. Newberry, George C. Hartoularos, Daniel M. C. Schwarz, Calla Martyn, Laura M. Gunsalus, Jack Strickland, Maureen Pittman, Taylor Arhar, Andrew F. Kung, Daniel R. Wong, Garrett Wong, Nishith R. Reddy, Matthew G. Jones, Aji Palar, Erik J. Navarro, Nick Hoppe, M. Grace Gordon, Douglas R. Wassarman, Jean Costello, Adam Catching
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 15, iss 8
ACS chemical biology, vol 15, iss 8
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8292e5bf8e0f1174d79b4faba3fc334b
Autor:
Rebecca E. Graff, Caroline G. Tai, Pui-Yan Kwok, Chun Chao, Clinton L. Cario, Jun Shan, Thomas J. Hoffmann, John S. Witte, Lori C. Sakoda, Stephen K. Van Den Eeden, Taylor B. Cavazos, David S. Aaronson, Nirupa R. Ghai, Joel Mefford, Neil Risch, Laurel A. Habel, Linda Kachuri, Eunice Wan, Nima C. Emami, Simon Wong, Sara R. Rashkin, Dilrini K. Ranatunga, Mark N. Kvale, Joseph C. Presti, Catherine Schaefer, Eric Jorgenson
The potential association between rare germline genetic variants and prostate cancer (PrCa) susceptibility has been understudied due to challenges with assessing rare variation. Furthermore, although common risk variants for PrCa have shown limited i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1906ded25035f4ad932d624a09e262cb
https://doi.org/10.1101/2020.02.12.929463
https://doi.org/10.1101/2020.02.12.929463
Autor:
Maruta A. Blatchins, Rebecca E. Graff, Douglas A. Corley, Stacey E. Alexeeff, Joshua D. Hoffman, Taylor B. Cavazos, Elad Ziv, Lancelote Leong, Lawrence H. Kushi, John S. Witte, Travis J. Meyers, Khanh K. Thai, Lori C. Sakoda, Linda Kachuri, Caroline G. Tai, Thomas J. Hoffmann, Laurel A. Habel, Nima C. Emami, Eric Jorgenson, Sara R. Rashkin, Stephen K. Van Den Eeden
Genetic factors that influence etiologic mechanisms shared across cancers could affect the risk of multiple cancer types. We investigated polygenic risk score (PRS)-specific pleiotropy across 17 cancers in two large population-based cohorts. The stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3730ec6ea40a71982cb8605641be00
https://doi.org/10.1101/2020.01.18.911578
https://doi.org/10.1101/2020.01.18.911578
Autor:
Lawrence H. Kushi, Stephen K. Van Den Eeden, Eric Jorgenson, John S. Witte, Laurel A. Habel, Taylor B. Cavazos, Joshua D. Hoffman, Travis J. Meyers, Lori C. Sakoda, Rebecca E. Graff, Nima C. Emami, Stacey E. Alexeeff, Elad Ziv, Thomas J. Hoffmann, Sara R. Rashkin, Maruta A. Blatchins, Khanh K. Thai, Linda Kachuri, Douglas A. Corley
Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. However, no studies have investigated pan-cancer pleiotropy within single, well-def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9700b6b4c720d47f2629c0c6c87de6fd
https://doi.org/10.1101/635367
https://doi.org/10.1101/635367
Autor:
Jirong Long, Lang Wu, Wei Zheng, Nima C. Emami, Matthew L. Freedman, Jifeng Wang, John S. Witte, Taylor B. Cavazos, Joshua A. Bauer, Rosalind A. Eeles, Xiao-Ou Shu, Yingchang Lu, Bogdan Pasaniuc, Christopher A. Haiman, Xingyi Guo, Qiuyin Cai, Kathryn L. Penney, Zsofia Kote-Jarai
Publikováno v:
Cancer Res
Cancer Research, 79(13), 3192-3204. American Association for Cancer Research Inc.
Wu, L, Wang, J, Cai, Q, Cavazos, T B, Emami, N C, Long, J, Shu, X-O, Lu, Y, Guo, X, Bauer, J A, Pasaniuc, B, Penney, K L, Freedman, M L, Kote-Jarai, Z, Witte, J S, Haiman, C A, Eeles, R A, Zheng, W & PRACTICAL, CRUK, BPC3, CAPS, PEGASUS Consortia 2019, ' Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk : A Transcriptome-Wide Association Study in Over 140,000 European Descendants ', Cancer Research, vol. 79, no. 13, pp. 3192-3204 . https://doi.org/10.1158/0008-5472.CAN-18-3536
Cancer Research, 79(13), 3192-3204. American Association for Cancer Research Inc.
Wu, L, Wang, J, Cai, Q, Cavazos, T B, Emami, N C, Long, J, Shu, X-O, Lu, Y, Guo, X, Bauer, J A, Pasaniuc, B, Penney, K L, Freedman, M L, Kote-Jarai, Z, Witte, J S, Haiman, C A, Eeles, R A, Zheng, W & PRACTICAL, CRUK, BPC3, CAPS, PEGASUS Consortia 2019, ' Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk : A Transcriptome-Wide Association Study in Over 140,000 European Descendants ', Cancer Research, vol. 79, no. 13, pp. 3192-3204 . https://doi.org/10.1158/0008-5472.CAN-18-3536
Genome-wide association study–identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel pro