Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Shannon M Mumenthaler"'
Autor:
Hermann B Frieboes, Bryan R Smith, Zhihui Wang, Masakatsu Kotsuma, Ken Ito, Armin Day, Benjamin Cahill, Colin Flinders, Shannon M Mumenthaler, Parag Mallick, Eman Simbawa, A S Al-Fhaid, S R Mahmoud, Sanjiv S Gambhir, Vittorio Cristini
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129433 (2015)
We combine mathematical modeling with experiments in living mice to quantify the relative roles of intrinsic cellular vs. tissue-scale physiological contributors to chemotherapy drug resistance, which are difficult to understand solely through experi
Externí odkaz:
https://doaj.org/article/e3487eba4853460f845a086b6083a380
Autor:
Sungmin Kim, Nikhil Baban Ghate, Sang Nam Kim, Suhn K. Rhie, Goar Smbatyan, Woojin An, Shannon M. Mumenthaler, Yonghwan Shin, Erin Spiller, Heinz-Josef Lenz
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2801-2817 (2021)
Molecular Oncology
Molecular Oncology
Histone modification is aberrantly regulated in cancer and generates an unbalanced state of gene transcription. VprBP, a recently identified kinase, phosphorylates histone H2A on threonine 120 (T120) and is involved in oncogenic transcriptional dysre
Autor:
Chiara Cremolini, Volker Heinemann, Joshua Millstein, Wu Zhang, Heinz-Josef Lenz, Natsuko Kawanishi, Hiroyuki Arai, Alfredo Falcone, Shivani Soni, Sebastian Stintzing, Francesca Battaglin, Jingyuan Wang, Fotios Loupakis, Shannon M. Mumenthaler, Priya Jayachandran
Publikováno v:
European Journal of Cancer. 150:133-142
Cancer stem cells (CSCs) are primarily maintained by a network of pluripotency transcription factors (PTFs). Given a close relationship of CSC regulation with epidermal growth factor receptor and vascular endothelial growth factor signalling, we inve
Autor:
Meng Qu, Francesca Battaglin, Evanthia T. Roussos Torres, Erin Spiller, Shivani Soni, Yuanzhong Pan, Heinz-Josef Lenz, Sofi Castanon, Priscilla Chan, Shannon M. Mumenthaler, Steve A. Kay
Publikováno v:
Oncogene
Disruption of the cellular pathway modulating endogenous 24-hour rhythms, referred to as ‘the circadian clock’, has been recently proven to be associated with cancer risk, development and progression. This pathway operates through a complex netwo
Autor:
Erin Spiller, Natasha Hashemi, Jasmine Foo, Roy Lau, Nolan Ung, Jordan Gasho, Ren X. Sun, Sarah Choung, Seung Il Kim, Emma J. Fong, Shannon M. Mumenthaler
Publikováno v:
Slas Discovery
3D cell culture models have been developed to better mimic the physiological environments that exist in human diseases. As such, these models are advantageous over traditional 2D cultures for screening drug compounds. However, the practicalities of t
Publikováno v:
Slas Discovery
Multicellular systems such as cancer suffer from immense complexity. It is imperative to capture the heterogeneity of these systems across scales to achieve a deeper understanding of the underlying biology and develop effective treatment strategies.
Autor:
Jingyuan Wang, Shivani Soni, Bodour Salhia, Shannon M. Mumenthaler, Christoph Mancao, Natsuko Kawanishi, Yi Xiao, Hiroyuki Arai, Wu Zhang, Heinz-Josef Lenz, Joshua Millstein, Priya Jayachandran, Aparna Raj Parikh, Francesca Battaglin
Publikováno v:
Br J Cancer
BACKGROUND: The TIMELESS–TIPIN complex protects the replication fork from replication stress induced by chemotherapeutic drugs. We hypothesised genetic polymorphisms of the TIMELESS–TIPIN complex may affect the response, progression-free survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d11e0a73f34da50ff55e94a2e3c482
https://europepmc.org/articles/PMC8727586/
https://europepmc.org/articles/PMC8727586/
Autor:
Sungmin Kim, Erin Spiller, Heinz-Josef Lenz, Nikhil Baban Ghate, Sang Nam Kim, Goar Smbatyan, Woojin An, Yonghwan Shin, Shannon M. Mumenthaler, Suhn K. Rhie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff6587b7609b36adef7b4d921d6fedc
https://doi.org/10.1002/1878-0261.13068/v3/response1
https://doi.org/10.1002/1878-0261.13068/v3/response1
Autor:
Colin Flinders, Seung Il Kim, Xin Liu, Amanda B. Hummon, Jessica K Lukowski, Shannon M. Mumenthaler, Rebecca A. Georgiadis
Publikováno v:
Anal Chem
Immunotherapies are treatments that use a patient's immune system to combat disease. One important type of immunotherapy employed in cancer treatments is the delivery of monoclonal antibodies to block growth receptors. In this manuscript, we develop
Autor:
Daniel Bsteh, Shivani Soni, Heather Ogana, Heinz-Josef Lenz, Stephen V. Frye, Stephanie H. Cholensky, Justin M. Rectenwald, Yibo Si, Oliver Bell, Jacqueline L. Norris, Junghyun L. Suh, Lindsey I. James, Tyler M. Weaver, Jessica D. Umana, Dmitri Kireev, Yong-Mi Kim, Bryce Hart, Shannon M. Mumenthaler, Brian Hardy, Cari A. Sagum, Catherine A. Musselman, Roy Lau, Gang Greg Wang, Dongxu Li, Ken H. Pearce, Mark T. Bedford, Carina Pribitzer
Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their central role in silencing and their misregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041c17c959746d5da4e46faee689c326
https://doi.org/10.1101/2021.02.23.432388
https://doi.org/10.1101/2021.02.23.432388