Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Sergio Rutella"'
Autor:
James O Lindsay, Daniel Hind, Lizzie Swaby, Hannah Berntsson, Mike Bradburn, Uday Bannur C, Jennifer Byrne, Christopher Clarke, Lauren Desoysa, Shahida Din, Richard Emsley, Gemma A Foulds, John Gribben, Christopher Hawkey, Peter M Irving, Peter Johnson, Majid Kazmi, Ellen Lee, Amanda Loban, Alan Lobo, Yashwant Mahida, Gordon Moran, Diana Papaioannou, Miles Parkes, Andrew Peniket, A Graham Pockley, Jack Satsangi, Sreedhar Subramanian, Simon Travis, Emily Turton, Ben Uttenthal, Sergio Rutella, John A Snowden
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 11, Iss 03 (2024)
Some text in this abstract has been reproduced from Lindsay J, Din S, Hawkey C, Hind D, Irving P, Lobo A, et al. OFR-9 An RCT of autologous stem-cell transplantation in treatment refractory Crohn’s disease (low-intensity therapy evaluation): ASTICl
Externí odkaz:
https://doaj.org/article/dc34c6a6762e4f599cb3fa947e2a353d
Autor:
Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung-On Yau, Rupkatha Mukhopadhyay, Benjamin Dickins, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Bruce R. Blazar, Vedran Radojcic, Joshua F. Zeidner, Andrea Arruda, Bofei Wang, Hussein A. Abbas, Mark D. Minden, Sarah K. Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Background Immune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generati
Externí odkaz:
https://doaj.org/article/9b9ef0d762ff4c06a07a3be5dd99fa73
Autor:
Raquel Alves, Stephanie E. B. McArdle, Jayakumar Vadakekolathu, Ana Cristina Gonçalves, Paulo Freitas-Tavares, Amélia Pereira, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro, Sergio Rutella
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regu
Externí odkaz:
https://doaj.org/article/e73c20ff4cc64a2a894e0706d59184ef
Autor:
Sarah Parisi, Chiara Sartor, Gianluca Cristiano, Antonio Curti, Annalisa Talami, Emanuela Ottaviani, Jayakumar Vadakekolathu, Matteo Olivi, Sarah Wagner, Simone Ragaini, Michele Cavo, Cristina Papayannidis, Giovanni Marconi, Stefania Paolini, Jacopo Nanni, Sergio Rutella, Darina Očadlíková, Giulia Corradi, Marilena Ciciarello
Publikováno v:
Blood Advances
Key Points The semaphorin receptor PLXNC1 is an IDO1-interacting gene and a strong predictor of survival in AML.An IDO1-related immune gene signature, including PLXNC1, predicts survival in AML.
Visual Abstract
The contribution of the bone
Visual Abstract
The contribution of the bone
Autor:
Ibrahim Aldoss, Ivana Gojo, Tung On Yau, Anbarasu Lourdusamy, Anjali S. Advani, Catherine Lai, Martin Bornhäuser, John F. DiPersio, Heidi Altmann, Martha Arellano, Michael P. Rettig, Bob Löwenberg, Stephen Reeder, Peter J. M. Valk, Jan K Davidson-Moncada, John E. Godwin, Sarah E. Church, Kendra Sweet, Jan Moritz Middeke, Tressa Hood, Friedrich Stölzel, John Muth, Gemma A. Foulds, Sergio Rutella, Farhad Ravandi, Jayakumar Vadakekolathu, Matthew J. Wieduwilt, Antonio Curti, Marilena Ciciarello
Publikováno v:
Blood Adv
Blood advances, 4(20), 5011-5024. American Society of Hematology
Blood advances, 4(20), 5011-5024. American Society of Hematology
Somatic TP53 mutations and 17p deletions with genomic loss of TP53 occur in 37% to 46% of acute myeloid leukemia (AML) with adverse-risk cytogenetics and correlate with primary induction failure, high risk of relapse, and dismal prognosis. Herein, we
Autor:
Javier De Las Rivas, Ana Cristina Gonçalves, Antonio Almeida, Ioannis P. Trougakos, Sergio Rutella, Ana Bela Sarmento Ribeiro, Raquel Alves
Publikováno v:
Cancers
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 13, Iss 4820, p 4820 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 13, Iss 4820, p 4820 (2021)
© 2021 by the authors.
Resistance to targeted therapies is a complex and multifactorial process that culminates in the selection of a cancer clone with the ability to evade treatment. Chronic myeloid leukemia (CML) was the first malignancy reco
Resistance to targeted therapies is a complex and multifactorial process that culminates in the selection of a cancer clone with the ability to evade treatment. Chronic myeloid leukemia (CML) was the first malignancy reco
Autor:
Tung On Yau, Gemma A. Foulds, Guodong Du, Christos Polytarchou, Benjamin Dickins, Sergio Rutella, Jayakumar Vadakekolathu
Background & AimsAnti-tumour necrosis factor-alpha (anti-TNFα) agents have been used for inflammatory bowel disease (IBD), however, it has up to 30% non-response rate. Identifying molecular pathways and finding reliable diagnostic biomarkers for pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd426422ecb3e0d1deb5072460fac77
https://doi.org/10.1101/2021.08.15.456400
https://doi.org/10.1101/2021.08.15.456400
Publikováno v:
Biology, Vol 10, Iss 723, p 723 (2021)
Biology
Biology
Simple Summary Parkinson’s disease is a neurodegenerative disorder characterized by the death of a specific subset of dopamine-producing neurons. This triggers problems with movement as dopamine is key in regulating motor control. To date, availabl
Autor:
Peter H. Sayre, Geoffrey L. Uy, Anjali S. Advani, Teia Curtis, Mojca Jongen-Lavrencic, Patrick J. Stiff, Patrick Kaminker, Jan K Davidson-Moncada, John Muth, Mary Beth Collins, Martha Arellano, Kuo Guo, Harry P. Erba, Martin Wermke, John E. Godwin, Ezio Bonvini, Ouiam Bakkacha, Kathy M. Tran, Erin Timmeny, Jennifer Seiler, Matteo Carrabba, Priyanka Patel, Jian Zhao, Fabio Ciceri, Max S. Topp, Roland B. Walter, Kenneth Jacobs, Ibrahim Aldoss, Christian Recher, G. Huls, Ashkan Emadi, Patrice Chevalier, Sergio Rutella, Emmanuel Gyan, Farhad Ravandi, Bob Löwenberg, Matthew J. Wieduwilt, Laura C. Michaelis, John F. DiPersio, Michael Byrne, Antonio Curti, Norbert Vey, Michael P. Rettig, Matthew C. Foster, Maya Kostova
Publikováno v:
Blood. 136:16-18
Introduction. Approximately 40% of patients (pts) with newly diagnosed AML either fail to achieve complete remission with intensive induction therapy or experience disease recurrence after a short remission (CR1 6 months), the probability of response
Autor:
Norbert Vey, Michael P. Rettig, John Muth, Leo Luznik, Matthew C. Foster, Ivana Gojo, Ashkan Emadi, Harry P. Erba, Ibrahim Aldoss, Martha Arellano, Farhad Ravandi, Roland B. Walter, Max S. Topp, Jayakumar Vadakekolathu, Michael Byrne, Bob Löwenberg, Patrick J. Stiff, Sergio Rutella, Christian Recher, Laura C. Michaelis, John F. DiPersio, Matthew J. Wieduwilt, Antonio Curti, Mojca Jongen-Lavrencic, Matteo Carrabba, Martin Wermke, Patrick Kaminker, Fabio Ciceri, Peter H. Sayre, Anjali S. Advani, Sarah E. Church, Emmanuel Gyan, Tung On Yau, G. Huls, Jan K Davidson-Moncada, John E. Godwin, Geoffrey L. Uy, Patrice Chevalier
Publikováno v:
Blood. 136:26-28
We have recently shown that bone marrow (BM) RNA profiles stratify patients with acute myeloid leukemia (AML) into immune-infiltrated and immune-depleted subtypes and that type I/II interferon (IFN)-related gene signatures associate with complete res