Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Schuck, P."'
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Niemann-Pick disease type C (NPC) is an autosomal recessive, progressive disorder resulting from variants in NPC1 or NPC2 that leads to the accumulation of cholesterol and other lipids in late endosomes and lysosomes. The clinical manifestat
Externí odkaz:
https://doaj.org/article/54c24adfdb8243819932abea70803bed
Autor:
Ai Nguyen, Huaying Zhao, Dulguun Myagmarsuren, Sanjana Srinivasan, Di Wu, Jiji Chen, Grzegorz Piszczek, Peter Schuck
Publikováno v:
eLife, Vol 13 (2024)
Genetic diversity is a hallmark of RNA viruses and the basis for their evolutionary success. Taking advantage of the uniquely large genomic database of SARS-CoV-2, we examine the impact of mutations across the spectrum of viable amino acid sequences
Externí odkaz:
https://doaj.org/article/69a87aec0aa54120ac8389e03fc2cdf5
Autor:
Laura K. Schuck, Wesley J. Neely, Shannon M. Buttimer, Camila F. Moser, Priscila C. Barth, Paulo E. Liskoski, Carolina de A. Caberlon, Victor Hugo Valiati, Alexandro M. Tozetti, C. Guilherme Becker
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Climate change has led to an alarming increase in the frequency and severity of wildfires worldwide. While it is known that amphibians have physiological characteristics that make them highly susceptible to fire, the specific impacts of wild
Externí odkaz:
https://doaj.org/article/c69d7216d80e47729d21b6e6eac7e6b7
Autor:
Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyr
Externí odkaz:
https://doaj.org/article/69835b309c8c4fcc8550fc5ffc4c0d4f
Autor:
Lingshan Wang, Jie Wang, Ji Feng, Mary Doi, Salvatore Pepe, Michael Pacanowski, Robert N. Schuck
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-8 (2022)
Abstract Background The small patient populations inherent to rare genetic diseases present many challenges to the traditional drug development paradigm. One major challenge is generating sufficient data in early phase studies to inform dose selectio
Externí odkaz:
https://doaj.org/article/b4c43e84434c4e4da686f28dd247da2c
Autor:
David Musheyev, Esther Miller, Natania Birnbaum, Elisheva Miller, Shoshana Erblich, Alyssa Schuck, Anya Alayev
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0283047 (2023)
Breast cancer is the second leading cause of cancer-related deaths in women and triple-negative breast cancer (TNBC), in particular, is an aggressive and highly metastatic type of breast cancer that does not respond to established targeted therapies
Externí odkaz:
https://doaj.org/article/4a0f75a71a8c4095a2297fae4a450622
Autor:
Charles M Russell, Katherine G Schaefer, Andrew Dixson, Amber LH Gray, Robert J Pyron, Daiane S Alves, Nicholas Moore, Elizabeth A Conley, Ryan J Schuck, Tommi A White, Thanh D Do, Gavin M King, Francisco N Barrera
Publikováno v:
eLife, Vol 11 (2022)
Candida albicans causes severe invasive candidiasis. C. albicans infection requires the virulence factor candidalysin (CL) which damages target cell membranes. However, the mechanism that CL uses to permeabilize membranes is unclear. We reveal that C
Externí odkaz:
https://doaj.org/article/79958a3cea334a74ad69da42c957104a
Autor:
Lila Lovergne, Dhruba Ghosh, Renaud Schuck, Aris A. Polyzos, Andrew D. Chen, Michael C. Martin, Edward S. Barnard, James B. Brown, Cynthia T. McMurray
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Although some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack methods to predict who has developed disease before the onset of symptoms, when onset will occ
Externí odkaz:
https://doaj.org/article/846890e2041e4915b5b464f2f470d9da
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Spatial learning can be based on intramaze cues and environmental boundaries. These processes are predominantly subserved by striatal- and hippocampal-dependent circuitries, respectively. Maturation and aging processes in these brain regions
Externí odkaz:
https://doaj.org/article/95c6a92937f046448da1b76b43b24d5a
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Objective To present the Pain-Track, a novel framework for the description and analysis of the pain experience based on its temporal evolution, around which intensity and other attributes of pain (texture, anatomy), interventions and clinica
Externí odkaz:
https://doaj.org/article/b6cb5afe626743ee8aa11d1a9de84d74