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of 1 160
pro vyhledávání: '"QD901-999"'
Publikováno v:
IUCrJ, Vol 8, Iss 6, Pp 973-979 (2021)
IUCrJ
IUCrJ
Understanding the catalytic mechanism of SARS-CoV-2 main protease (Mpro) can help in guiding drug design of specific small-molecule antivirals. A 2.0 Å resolution room-temperature X-ray crystal structure of inactive C145A mutant Mpro in complex with
Autor:
Bohuslav Melichar, Marketa Pospiskova, Ondřej Strouhal, Martin Doležel, Zuzana Vlachová, Eva Hlídková
Publikováno v:
Pteridines, Vol 32, Iss 1, Pp 93-97 (2021)
The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer. Sixteen patients with histologically confirm
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 11, Pp 1091-1094 (2021)
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications
The title compound, C21H25NO3, crystallizes as a racemic twin in the chiral space group P21. Both R- and S-enantiomers are connected into infinite helical chains by weak C—H⋯O hydrogen bonds between the phenyl ring of the benzoyl group and the
Publikováno v:
IUCrJ, Vol 8, Iss 5, Pp 823-832 (2021)
Transcription factors are the primary regulators of gene expression and recognize specific DNA sequences under diverse physiological conditions. Although they are vital for many important cellular processes, it remains unclear when and how transcript
Autor:
Mihai R. Gherase, David E. B. Fleming
Publikováno v:
Crystals, Vol 10, Iss 1, p 12 (2019)
For the past several decades, synchrotron radiation has been extensively used to measure the spatial distribution and chemical affinity of elements found in trace concentrations (
Externí odkaz:
https://doaj.org/article/ef43373daf784c078afc6f3d88267ba7
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 9, Pp 880-886 (2021)
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 9, Pp 880-886 (2021)
Five new bis(arylamide)dichloridozinc(II) complexes have been prepared and characterized. All of the complexes contain hydrogen bonds between the amide N—H group and the amide carbonyl oxygen atoms or the chlorine atoms, forming extended ne
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 8, Pp 809-813 (2021)
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications
Two orthorhombic polymorphs of the anti-inflammatory corticosteroid tixocortol pivalate have been identified. The two structures are characterized by layers of molecules connected by strong O—H⋯O hydrogen bonds.
Two polymorphs, (I) and
Two polymorphs, (I) and
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 8, Pp 804-808 (2021)
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications
The chemical structures of two withanolides, isolated from the leaves of Physalis angulata by column chromatography, were studied. The isolated compounds are (17S,20R,22R,24R,25S)-5β,6β:20,24-diepoxy-4β,25-dihydroxy-1-oxowith-2-en-26,22-olide
Publikováno v:
IUCrJ
IUCrJ, Vol 8, Iss 4, Pp 684-694 (2021)
IUCrJ, Vol 8, Iss 4, Pp 684-694 (2021)
The crystal structure of CYP105D18 and its unique structural features for papaverine N-oxidation are presented.
The bacterial CYP105 family is involved in secondary metabolite biosynthetic pathways and plays essential roles in the biotransformat
The bacterial CYP105 family is involved in secondary metabolite biosynthetic pathways and plays essential roles in the biotransformat
Publikováno v:
Pteridines, Vol 32, Iss 1, Pp 23-32 (2021)
Objective The aim of this study was to investigate the correlation between MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) by pooling the open published relevant studies. Method