Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Noora Puhakka"'
Autor:
Noora Puhakka, Anna Maria Bot, Niina Vuokila, Konrad Jozef Debski, Katarzyna Lukasiuk, Asla Pitkänen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172521 (2017)
Traumatic brain injury (TBI) can result in several dentate gyrus-regulated disabilities. Almost nothing is known about the chronic molecular changes after TBI, and their potential as treatment targets. We hypothesized that chronic transcriptional alt
Externí odkaz:
https://doaj.org/article/9bb1c9c2c34c4752abc017c797d14d0d
Autor:
Noora Puhakka, Asla Pitkänen, Johanna Hiltunen, Anssi Lipponen, Günther Sperk, Xavier Ekolle Ndode-Ekane, Meinrad Drexel
Publikováno v:
Neuroscience. 475:52-72
Traumatic brain injury (TBI) causes 10–20% of structural epilepsy, with seizures typically originating in the cortex. Alterations in the neuronal microcircuits in the cortical epileptogenic zone, however, are poorly understood. Here, we assessed TB
Publikováno v:
Neuroscience. 433:21-35
Mechanisms initiated by traumatic brain injury (TBI), leading to the development of progressive secondary injury are poorly understood. MicroRNAs (miRNAs) have a proposed role in orchestrating the post-injury aftermath as a single miRNA can control t
Autor:
Roxanne Aniceto, Denes V. Agoston, Gregory Smith, Pedro Andrade de Abreu, Terence J. O'Brien, Matthew R. Hudson, Shalini Das Gupta, Pablo M. Casillas-Espinosa, Alaa Kamnaksh, Xavier Ekolle Ndode-Ekane, Sandy R. Shultz, Rhys D. Brady, Riikka Immonen, Jesse Mccullough, Noora Puhakka, Idrish Ali, Asla Pitkänen, Richard J. Staba, César Emmanuel Santana-Gómez, Nigel C. Jones
Publikováno v:
Epilepsy Research. 149:92-101
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is an international, multicenter, multidisciplinary study aimed at preventing epileptogenesis (EpiBioS4Rx: https://epibios.loni.usc.edu/). One of the study's major objective
Autor:
Tomi Paananen, Elina Hämäläinen, Asla Pitkänen, Noora Puhakka, Niina Lapinlampi, Xavier Ekolle Ndode-Ekane, Pedro Andrade
Publikováno v:
EpilepsiaREFERENCES. 61(9)
OBJECTIVE To identify postinjury physiologic, behavioral, and cognitive biomarkers for posttraumatic epilepsy to enrich study populations for long-term antiepileptogenesis studies. METHODS The EPITARGET cohort with behavioral follow-up and 1-month 24
Autor:
Robert Ciszek, Natallie Kajevu, Xavier Ekolle Ndode-Ekane, Jenni Kyyriäinen, Shalini Das Gupta, Mette Heiskanen, Tomi Paananen, Asla Pitkänen, Leonardo Lara-Valderrábano, Niina Lapinlampi, Niina Vuokila, Pedro Andrade, Noora Puhakka, Ivette Bañuelos-Cabrera
Publikováno v:
Epilepsybehavior : EB. 121
A biomarker is a characteristic that can be objectively measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecu
Autor:
Asla Pitkänen, Leonardo Lara-Valderrábano, Jenni Karttunen, Xavier Ekolle Ndode-Ekane, Mehwish Anwer, Noora Puhakka
Publikováno v:
Journal of neurotrauma. 37(7)
Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophy
Autor:
Gregory Smith, Idrish Ali, Richard J. Staba, César Emmanuel Santana-Gómez, Rhys D. Brady, Emma L. Braine, Tomi Paananen, Pedro Andrade, Riikka Immonen, Xavier Ekolle Ndode-Ekane, Noora Puhakka, Matthew R. Hudson, Jussi Tohka, Pablo M. Casillas-Espinosa, Terence J. O'Brien, Sandy R. Shultz, Robert Ciszek, Nigel C. Jones, Asla Pitkänen, Piero Perucca
Publikováno v:
Epilepsy Res
Rationale The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Centre without walls is an NIH funded multicenter consortium. One of EpiBioS4Rx projects is a preclinical post-traumatic epileptogenesis biomarker study that invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f31fe9664ccc8ded3340863076b0b59
https://escholarship.org/uc/item/2w8178fh
https://escholarship.org/uc/item/2w8178fh
Publikováno v:
Neuroscience. 415
Sushi repeat-containing protein X-linked 2 (SRPX2) is a novel hypothalamic protein and a ligand of the urokinase-type plasminogen activator receptor (uPAR), which is essential for proteolysis of extracellular matrix and tissue remodeling after an ins
Autor:
Matthew R. Hudson, Noora Puhakka, Alaa Kamnaksh, Pablo M. Casillas-Espinosa, Richard J. Staba, Robert Ciszek, Terence J. O'Brien, Tomi Paananen, Rhys D. Brady, Cesar Santana Gomez, Jussi Tohka, Pedro Andrade, Asla Pitkänen, Xavier Ekolle Ndode-Ekane, Niina Lapinlampi, Gregory Smith, Idrish Ali, Sandy R. Shultz, Riikka Immonen
Publikováno v:
Epilepsy research. 150
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a National Institutes for Neurological Diseases and Stoke funded Centers-Without-Walls international multidisciplinary study aimed at preventing epileptogenesis. The prec