Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Matthew R. Sydes"'
Autor:
Emily Grist, Stefanie Friedrich, Christopher Brawley, Larissa Mendes, Marina Parry, Adnan Ali, Aine Haran, Alex Hoyle, Claire Gilson, Sharanpreet Lall, Leila Zakka, Carla Bautista, Alex Landless, Karolina Nowakowska, Anna Wingate, Daniel Wetterskog, A. M. Mahedi Hasan, Nafisah B. Akato, Malissa Richmond, Sofeya Ishaq, Nik Matthews, Anis A. Hamid, Christopher J. Sweeney, Matthew R. Sydes, Daniel M. Berney, Stefano Lise, STAMPEDE investigators, Mahesh K. B. Parmar, Noel W. Clarke, Nicholas D. James, Paolo Cremaschi, Louise C. Brown, Gerhardt Attard
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Genomic copy number alterations commonly occur in prostate cancer and are one measure of genomic instability. The clinical implication of copy number change in advanced prostate cancer, which defines a wide spectrum of disease fro
Externí odkaz:
https://doaj.org/article/506e0f56118040028d430cc8873797f0
Autor:
James M. S. Wason, Munyaradzi Dimairo, Katie Biggs, Sarah Bowden, Julia Brown, Laura Flight, Jamie Hall, Thomas Jaki, Rachel Lowe, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Nina Wilson, Christina Yap, Helen Hancock, Rebecca Maier
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations where they have potential to br
Externí odkaz:
https://doaj.org/article/22339b16e2cc4f4288ebaef1419f4518
Autor:
Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James M. S. Wason
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resources are required to con
Externí odkaz:
https://doaj.org/article/54a6d8a22728449aaca970ea965fdb82
Autor:
Chris C. Parker, Nicholas D. James, Christopher D. Brawley, Noel W. Clarke, Adnan Ali, Claire L. Amos, Gerhardt Attard, Simon Chowdhury, Adrian Cook, William Cross, David P. Dearnaley, Hassan Douis, Duncan C. Gilbert, Clare Gilson, Silke Gillessen, Alex Hoyle, Rob J. Jones, Ruth E. Langley, Zafar I. Malik, Malcolm D. Mason, David Matheson, Robin Millman, Mary Rauchenberger, Hannah Rush, J Martin Russell, Hannah Sweeney, Amit Bahl, Alison Birtle, Lisa Capaldi, Omar Din, Daniel Ford, Joanna Gale, Ann Henry, Peter Hoskin, Mohammed Kagzi, Anna Lydon, Joe M. O’Sullivan, Sangeeta A. Paisey, Omi Parikh, Delia Pudney, Vijay Ramani, Peter Robson, Narayanan Nair Srihari, Jacob Tanguay, Mahesh K. B. Parmar, Matthew R. Sydes, for the STAMPEDE Trial Collaborative Group
Publikováno v:
PLoS Medicine, Vol 19, Iss 6 (2022)
Background STAMPEDE has previously reported that radiotherapy (RT) to the prostate improved overall survival (OS) for patients with newly diagnosed prostate cancer with low metastatic burden, but not those with high-burden disease. In this final anal
Externí odkaz:
https://doaj.org/article/59bd277f4a854b248d9e56e359be5b75
Autor:
Caroline S. Clarke, Rachael M. Hunter, Andrea Gabrio, Christopher D. Brawley, Fiona C. Ingleby, David P. Dearnaley, David Matheson, Gerhardt Attard, Hannah L. Rush, Rob J. Jones, William Cross, Chris Parker, J. Martin Russell, Robin Millman, Silke Gillessen, Zafar Malik, Jason F. Lester, James Wylie, Noel W. Clarke, Mahesh K. B. Parmar, Matthew R. Sydes, Nicholas D. James
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Adding abiraterone acetate (AA) plus prednisolone (P) to standard of care (SOC) improves survival in newly diagnosed advanced prostate cancer (PC) patients starting hormone therapy. Our objective was to determine the value for money to the English Na
Externí odkaz:
https://doaj.org/article/25d4f0b869284f6783de1ecc79032cf2
Autor:
Megan McCarthy, Linda O'Keeffe, Paula R. Williamson, Matthew R. Sydes, Amanda Farrin, Fiona Lugg-Widger, Gwyneth Davies, Kerry Avery, An-Wen Chan, Linda Kwakkenbos, Brett D. Thombs, Alan Watkins, Lars G. Hemkens, Chris Gale, Merrick Zwarenstein, Sinead M. Langan, Lehana Thabane, Edmund Juszczak, David Moher, Patricia M. Kearney
Publikováno v:
HRB Open Research, Vol 4 (2021)
Background: Protocols are an essential document for conducting randomised controlled trials (RCTs). However, the completeness of the information provided is often inadequate. To help improve the content of trial protocols, an international group of s
Externí odkaz:
https://doaj.org/article/5b3d6f79760c45a885f72283f1f5c871
Autor:
Nurulamin M. Noor, Sarah L. Pett, Hanif Esmail, Angela M. Crook, Claire L. Vale, Matthew R. Sydes, Mahesh K.B. Parmar
Publikováno v:
F1000Research, Vol 9 (2020)
Global health pandemics, such as coronavirus disease 2019 (COVID-19), require efficient and well-conducted trials to determine effective interventions, such as treatments and vaccinations. Early work focused on rapid sequencing of severe acute respir
Externí odkaz:
https://doaj.org/article/61d8b86fa4a24a4f819a91086761b336
Autor:
Nurulamin M. Noor, Sarah L. Pett, Hanif Esmail, Angela M. Crook, Claire L. Vale, Matthew R. Sydes, Mahesh K.B. Parmar
Publikováno v:
F1000Research, Vol 9 (2020)
Global health pandemics, such as coronavirus disease 2019 (COVID-19), require efficient and well-conducted trials to determine effective interventions, such as treatments and vaccinations. Early work focused on rapid sequencing of severe acute respir
Externí odkaz:
https://doaj.org/article/22a7038099c64646b63619103441991d
Autor:
Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap, Thomas Jaki
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are often more efficient, informativ
Externí odkaz:
https://doaj.org/article/efc892793b0644d397320bd46ec68965
Autor:
Sarah L. Kerns, Leila Dorling, Laura Fachal, Søren Bentzen, Paul D.P. Pharoah, Daniel R. Barnes, Antonio Gómez-Caamaño, Ana M. Carballo, David P. Dearnaley, Paula Peleteiro, Sarah L. Gulliford, Emma Hall, Kyriaki Michailidou, Ángel Carracedo, Michael Sia, Richard Stock, Nelson N. Stone, Matthew R. Sydes, Jonathan P. Tyrer, Shahana Ahmed, Matthew Parliament, Harry Ostrer, Barry S. Rosenstein, Ana Vega, Neil G. Burnet, Alison M. Dunning, Gillian C. Barnett, Catharine M.L. West
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 150-163 (2016)
Nearly 50% of cancer patients undergo radiotherapy. Late radiotherapy toxicity affects quality-of-life in long-term cancer survivors and risk of side-effects in a minority limits doses prescribed to the majority of patients. Development of a test pre
Externí odkaz:
https://doaj.org/article/6a03d9a7bdc9422d837243b1ccbd49a0