Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marc Valentine"'
Autor:
Kaitly J. Woodard, Phillip A. Doerfler, Kalin D. Mayberry, Akshay Sharma, Rachel Levine, Jonathan Yen, Virginia Valentine, Lance E. Palmer, Marc Valentine, Mitchell J. Weiss
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
We characterized the human β-like globin transgenes in two mouse models of sickle cell disease (SCD) and tested a genome-editing strategy to induce red blood cell fetal hemoglobin (HbF; α2γ2). Berkeley SCD mice contain four to 22 randomly arranged
Externí odkaz:
https://doaj.org/article/c7a2b29fe3814d94a95e8c2dce8aa30e
Autor:
Jeffrey E. Rubnitz, Masayuki Umeda, Todd A. Alonzo, Jenny L. Smith, Sherif Abdelhamed, Jamie L. Maciaszek, Michael Rusch, Ilaria Iacobucci, M. Madan Babu, Jinghui Zhang, Pandurang Kolekar, Evadnie Rampersaud, Jing Ma, Guangchun Song, Gang Wu, Jeffery M. Klco, James R. Downing, Hiroto Inaba, Xiaotu Ma, Melvin Edward Thomas, Scott G. Foy, Evan Parganas, Yanling Liu, Yi-Cheng Wang, Marc Valentine, Bensheng Ju, Stanley Pounds, Juan Martin Barajas, Tamara Westover, Quang Tran, Huiyun Wu, Jonathan Miller, Amanda R. Leonti, Benjamin J. Huang, Michael P. Walsh, Virginia Valentine, Rhonda E. Ries, John Easton, Jason Myers, Andrew B. Kleist, Kohei Hagiwara, Delaram Rahbarinia, Xiao-Long Chen, Ryan Hiltenbrand, Soheil Meshinchi, Liqing Tian, Charles G. Mullighan, Yen-Chun Liu
Publikováno v:
Blood. 138:LBA-4
Children with acute myeloid leukemia (AML) have a dismal prognosis due to a high relapse rate; however, the molecular basis leading to relapsed pediatric AML has not yet been fully characterized. To define the spectrum of alterations common at relaps
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate
Autor:
Marc Valentine, Patrick A. Zweidler-McKay, Sa A. Wang, Kathryn G. Roberts, Nitin Jain, Charles G. Mullighan, Marina Konopleva, Xinyan Lu, Maitrayee Goswami, Jeffrey L. Jorgensen, Sergej Konoplev, Carlos E. Bueso-Ramos, Juan Ouyang
Publikováno v:
American Journal of Clinical Pathology. 147:357-363
Objectives Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. We analyzed CRLF2 expression and
Autor:
Xiang Chen, John Easton, Issam Al Diri, Daniel Putnam, Michael A. Dyer, Lyra Griffiths, Beisi Xu, Marc Valentine, Dianna A. Johnson, Shondra Miller, Marybeth S. Lupo, Sharon Frase, Jackie L. Norrie, Jiakun Zhang, Ying Shao, Xin Zhou, Victoria Honnell, Valerie Stewart
Publikováno v:
Neuron
More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-spe
Autor:
Diane Flasch, Jinghui Zhang, Yanling Liu, Michael Rusch, Suzanne J. Baker, Robin Paul, Jaimin Patel, Chunliang Li, Ying Shao, Edgar Sioson, Xiaotu Ma, Yu Liu, Liqing Tian, John Easton, Marc Valentine, Samuel W. Brady, Scott Newman, Jian Wang, Xin Zhou, Michael N. Edmonson
Publikováno v:
Cancer Cell
GenomePaint (https://genomepaint.stjude.cloud/) is an interactive visualization platform for whole-genome, whole-exome, transcriptome, and epigenomic data of tumor samples. Its design captures the inter-relatedness between DNA variations and RNA expr
Autor:
Shunsuke Kimura, Charles G. Mullighan, Jeffery M. Klco, Xiao-Long Chen, Xiaotu Ma, Anna Stengel, Sonja Seliger, Zhaohui Gu, Wolfgang Kern, Chunxu Qu, Ilaria Iacobucci, Torsten Haferlach, Lindsey E. Montefiori, Jing Ma, Marc Valentine, Kirsten Dickerson, Beisi Xu, Tamara Westover, Gang Wu, Claudia Haferlach
Publikováno v:
Blood. 136:LBA-3
Lindsey Montefiori, Sonja Seliger, and Zhaohui Gu contributed equally. Acute leukemias of ambiguous lineage (ALAL), including those that express combinations of myeloid, T-lineage and stem cell markers such as T/myeloid mixed phenotype acute leukemia
Autor:
Abbas Shirinifard, Issam Al Diri, Dianna Johnson, Michael A. Dyer, Daniel Putnam, Marybeth S. Lupo, Jiakun Zhang, Sharon Frase, Shondra Miller, Beisi Xu, John Easton, Jackie L. Norrie, Valerie Stewart, Xiang Chen, Ying Shao, Marc Valentine, Lyra Griffiths, Victoria Honnell
The nuclei of rod photoreceptors in mice and other nocturnal species have an unusual inverted chromatin structure: the heterochromatin is centrally located to help focus light and improve photosensitivity. To better understand this unique nuclear org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcc49bd83f0e20fbbf7b270746cd811
https://doi.org/10.1101/369702
https://doi.org/10.1101/369702
Autor:
Seungjae Lee, Elizabeth Stewart, James R. Downing, Armita Bahrami, Heather L. Mulder, Marc Valentine, Jianrong Wu, Rani E. George, Donald Yergeau, Michael D. Hogarty, Maged Zeineldin, Elaine R. Mardis, Xin Zhou, Sara M. Federico, Beisi Xu, Anang A. Shelat, Richard K. Wilson, Yanling Liu, Jinghui Zhang, Jongrye Jeon, Arlene Naranjo, Shondra M. Pruett-Miller, John Easton, Michael R. Clay, Collin Van Ryn, Lyra Griffiths, Xiang Chen, Yiping Fan, Marcin Kamiński, Alberto S. Pappo, Michael A. Dyer
SUMMARYAggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9c9691bc389d4e691e3cbd0c5b70af
https://doi.org/10.1101/379636
https://doi.org/10.1101/379636
Autor:
Jinghui Zhang, Richard C. Harvey, Julie M. Gastier-Foster, Cheryl L. Willman, Nyla A. Heerema, Leonard A. Mattano, Mignon L. Loh, Kathryn G. Roberts, William L. Carroll, Shalini C. Reshmi, Zhaohui Gu, Marc Valentine, Debbie Payne-Turner, Andrew J. Carroll, Heather Jenkins, Michael J. Borowitz, Brent L. Wood, Elizabeth A. Raetz, Kinnari Patel, I-Ming Chen, Meenakshi Devidas, Yaqi Zhao, Charles G. Mullighan, Eileen Stonerock, Yunfeng Dai, Stephen P. Hunger, Kelly W. Maloney
Publikováno v:
Blood. 132(8)
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL; BCR-ABL1-like ALL) in children with National Cancer Institute (NCI) intermediate- or high-risk (HR) ALL is associated with poor outcome. Ph-like ALL is characterized by genetic a