Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lauren Svenson"'
Autor:
Chris Twitty, Irene Wapnir, David A. Canton, Hiroshi Nagata, Herbert Kim Lyerly, Donna Bannavong, Erika J. Crosby, Takuya Osada, Melinda L. Telli, Lauren Svenson, Erica Browning, Kellie Malloy, Chaitanya R. Acharya, Reneta Hermiz, Kaitlin Zablotsky
Publikováno v:
Cancer Research. 81:PS17-22
Interleukin-12 (IL-12) is a pro-inflammatory cytokine involved in the generation of an inflammatory tumor microenvironment and is critical in eliciting a productive anti-tumor immune response. It has been investigated as an anti-cancer therapeutic us
Autor:
Erica Browning, Erika J. Crosby, Takuya Osada, Bernard A. Fox, Carlo Bifulco, Jendy Sell, Irene Wapnir, Melinda L. Telli, Kaitlin Zablotsky, Reneta Hermiz, Kellie Malloy Foerter, Robert H. Pierce, Chaitanya R. Acharya, Kim Jaffe, Donna Bannavong, Mai Hope Le, H. Kim Lyerly, Shawn M. Jensen, Carmen Ballesteros-Merino, David A. Canton, Christopher G. Twitty, Hiroshi Nagata, Lauren Svenson
Publikováno v:
Clin Cancer Res
Purpose: Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) have entered the therapeutic landscape in TNBC, but only a mino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c48e8953fa4ba2b471eaae121c3944b
https://europepmc.org/articles/PMC8102331/
https://europepmc.org/articles/PMC8102331/
Autor:
Christopher Stuart Baker, Jack Lee, Tom Van Hagen, Victoria Atkinson, Bernard A. Fox, Carmen Ballesteros-Merino, Eric D. Whitman, Kellie Malloy Foerter, Reneta Hermiz, Sajeve Thomas, Scott J. Diede, Elizabeth Buchbinder, Katy K. Tsai, Catalin Mihalcioiu, Shawn M. Jensen, Rachel Roberts-Thomson, Sandra Aung, David A. Canton, Alain Algazi, Christopher G. Twitty, Mecker G. Möller, Clemens Krepler, Donna Bannavong, Emmett V. Schmidt, Marcus O. Butler, John R. Hyngstrom, Erica Browning, Jon Salazar, M. Shaheen, Adil Daud, Matteo S. Carlino, Andrew Mant, C. Lance Cowey, Gregory A. Daniels, Lauren Svenson, Pablo Fernandez-Penas, Igor Puzanov, Jendy Sell, Andrew Haydon
Publikováno v:
Late-breaking abstracts.
Background Electroporated plasmid IL-12 (TAVO or tavokinogene telseplasmid) is a novel pro-inflammatory intratumoral therapy with substantial single agent activity in melanoma, which has been shown to synergize with anti-PD-1 antibodies in patients p
Autor:
Erica Browning, Anandaroop Mukhopadhyay, Jon Salazar, David A. Canton, Reneta Hermiz, Daniel T. Fisher, Lauren Svenson, Christopher G. Twitty, Joseph J. Skitzki, Jack Y. Lee, Bianca Nguyen, Mia Han, Daniel O'Connor
Publikováno v:
Cancer Research. 80:LB-396
Clinical and preclinical studies have demonstrated that plasmid IL-12 (tavokinogene telseplasmid; TAVO) delivered intratumorally via electroporation drives IFN-γ expression and recruits T cells to the tumor microenvironment, ultimately yielding dura
Autor:
Christopher G. Twitty, Erica Browning, Jon Salazar, Jack Y. Lee, Kellie Malloy, Mia Han, Lauren Svenson, Daniel S. O'Connor, David A. Canton, Chris Baker, Reneta Hermiz, Anandaroop Mukhopadhyay, Bianca Nguyen
Publikováno v:
Cancer Research. 80:LB-390
Intratumoral (IT) delivery of plasmid IL-12 (tavokinogene telseplasmid; tavo) via electroporation (EP), collectively referred as IT-tavo-EP, generates immunologically-relevant levels of localized IL-12, triggering regression of both treated and dista